Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials

por Hey-Hadavi, Juliana, Seekins, Daniel, Palmer, Melissa, Coffey, Denise, Caminis, John, Abdullaev, Sandzhar, Patwardhan, Meenal, Tyler, Haifa, Raheja, Ritu, Stanley, Ann Marie, Pineda-Salgado, Liliam, Bourdet, David L., Andrade, Raul J., Hayashi, Paul H., Dimick-Santos, Lara, Rockey, Don C., Estilo, Alvin
Publicado 2021

Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepat...

por Treem, William R., Palmer, Melissa, Lonjon-Domanec, Isabelle, Seekins, Daniel, Dimick-Santos, Lara, Avigan, Mark I., Marcinak, John F., Dash, Ajit, Regev, Arie, Maller, Eric, Patwardhan, Meenal, Lewis, James H., Rockey, Don C., Di Bisceglie, Adrian M., Freston, James W., Andrade, Raul J., Chalasani, Naga
Publicado 2020

Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

por Picchio, Camila A., Lens, Sabela, Hernandez-Guerra, Manuel, Arenas, Juan, Andrade, Raúl J., Crespo, Javier, García-Samaniego, Javier, Romero-Gómez, Manuel, Turnes, Juan, Calleja, José Luis, Simón, Miguel Ángel, White, Trenton M., Riveiro-Barciela, Mar, Pocurull, Anna, Morales-Arraez, Dalia, Gómez, Alexandra, Buti, Maria, Lazarus, Jeffrey V.
Publicado 2021

Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries

por Bessone, Fernando, Ferrari, Antonella, Hernandez, Nelia, Mendizabal, Manuel, Ridruejo, Ezequiel, Zerega, Alina, Tanno, Federico, Reggiardo, Maria Virginia, Vorobioff, Julio, Tanno, Hugo, Arrese, Marco, Nunes, Vinicius, Tagle, Martin, Medina-Caliz, Inmaculada, Robles-Diaz, Mercedes, Niu, Hao, Alvarez-Alvarez, Ismael, Stephens, Camilla, Lucena, M. Isabel, Andrade, Raul J.
Publicado 2022

Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery

por Peta, Valentina, Tse, Chantal, Perazzo, Hugo, Munteanu, Mona, Ngo, Yen, Ngo, An, Ramanujam, Nittia, Verglas, Lea, Mallet, Maxime, Ratziu, Vlad, Thabut, Dominique, Rudler, Marika, Thibault, Vincent, Schuppe-Koistinen, Ina, Bonnefont-Rousselot, Dominique, Hainque, Bernard, Imbert-Bismut, Françoise, Merz, Michael, Kullak-Ublick, Gerd, Andrade, Raul, van Boemmel, Florian, Schott, Eckart, Poynard, Thierry
Publicado 2017

Acute hepatitis after COVID-19 vaccine: case series by the International autoimmune hepatitis group (IAIHG) and the european reference network on hepatological diseases (ERN RARE-L...

por Codoni, Greta, Gracia Villamil, Maria Alejandra, Stättermayer, Albert, Castiella, Agustin, Schramm, Christoph, Weltzsch, Jan-Philipp, Sebode, Marcial, Bernsmeier, Christine, Karnsakul, Wikrom, Lleo, Ana, Gevers, Tom, Kupcinskas, Limas, Hernandez, Nélia, Cerny, Andreas, Ghielmetti, Michele, Vergani, Diego, Mieli-Vergani, Giorgina, Bandera, Jose Pinazo, Lucena, Maria Isabel, Andrade, Raul J., Zen, Yoh, Taubert, Richard
Publicado 2022

Elevated levels of circulating CDH5 and FABP1 in association with human drug‐induced liver injury

por Mikus, Maria, Drobin, Kimi, Gry, Marcus, Bachmann, Julie, Lindberg, Johan, Yimer, Getnet, Aklillu, Eleni, Makonnen, Eyasu, Aderaye, Getachew, Roach, James, Fier, Ian, Kampf, Caroline, Göpfert, Jens, Perazzo, Hugo, Poynard, Thierry, Stephens, Camilla, Andrade, Raúl J., Lucena, M Isabel, Arber, Nadir, Uhlén, Mathias, Watkins, Paul B., Schwenk, Jochen M., Nilsson, Peter, Schuppe‐Koistinen, Ina
Publicado 2016

Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease

por Gallego-Durán, Rocío, Cerro-Salido, Pablo, Gomez-Gonzalez, Emilio, Pareja, María Jesús, Ampuero, Javier, Rico, María Carmen, Aznar, Rafael, Vilar-Gomez, Eduardo, Bugianesi, Elisabetta, Crespo, Javier, González-Sánchez, Francisco José, Aparcero, Reyes, Moreno, Inmaculada, Soto, Susana, Arias-Loste, María Teresa, Abad, Javier, Ranchal, Isidora, Andrade, Raúl Jesús, Calleja, Jose Luis, Pastrana, Miguel, Iacono, Oreste Lo, Romero-Gómez, Manuel
Publicado 2016

A morphological method for ammonia detection in liver

por Gutiérrez-de-Juan, Virginia, López de Davalillo, Sergio, Fernández-Ramos, David, Barbier-Torres, Lucía, Zubiete-Franco, Imanol, Fernández-Tussy, Pablo, Simon, Jorge, Lopitz-Otsoa, Fernando, de las Heras, Javier, Iruzubieta, Paula, Arias-Loste, María Teresa, Villa, Erica, Crespo, Javier, Andrade, Raúl, Lucena, M. Isabel, Varela-Rey, Marta, Lu, Shelly C., Mato, José M., Delgado, Teresa Cardoso, Martínez-Chantar, María-Luz
Publicado 2017

Scientific opinion on the safety of monacolins in red yeast rice

por Younes, Maged, Aggett, Peter, Aguilar, Fernando, Crebelli, Riccardo, Dusemund, Birgit, Filipič, Metka, Frutos, Maria Jose, Galtier, Pierre, Gott, David, Gundert‐Remy, Ursula, Kuhnle, Gunter Georg, Lambré, Claude, Leblanc, Jean‐Charles, Lillegaard, Inger Therese, Moldeus, Peter, Mortensen, Alicja, Oskarsson, Agneta, Stankovic, Ivan, Waalkens‐Berendsen, Ine, Woutersen, Rudolf Antonius, Andrade, Raul J., Fortes, Cristina, Mosesso, Pasquale, Restani, Patrizia, Pizzo, Fabiola, Smeraldi, Camilla, Wright, Matthew
Publicado 2018

Scientific opinion on the safety of green tea catechins

por Younes, Maged, Aggett, Peter, Aguilar, Fernando, Crebelli, Riccardo, Dusemund, Birgit, Filipič, Metka, Frutos, Maria Jose, Galtier, Pierre, Gott, David, Gundert‐Remy, Ursula, Lambré, Claude, Leblanc, Jean‐Charles, Lillegaard, Inger Therese, Moldeus, Peter, Mortensen, Alicja, Oskarsson, Agneta, Stankovic, Ivan, Waalkens‐Berendsen, Ine, Woutersen, Rudolf Antonius, Andrade, Raul J, Fortes, Cristina, Mosesso, Pasquale, Restani, Patrizia, Arcella, Davide, Pizzo, Fabiola, Smeraldi, Camilla, Wright, Matthew
Publicado 2018

Safety of hydroxyanthracene derivatives for use in food

por Younes, Maged, Aggett, Peter, Aguilar, Fernando, Crebelli, Riccardo, Filipič, Metka, Frutos, Maria Jose, Galtier, Pierre, Gott, David, Gundert‐Remy, Ursula, Kuhnle, Gunter Georg, Lambré, Claude, Leblanc, Jean‐Charles, Lillegaard, Inger Therese, Moldeus, Peter, Mortensen, Alicja, Oskarsson, Agneta, Stankovic, Ivan, Waalkens‐Berendsen, Ine, Woutersen, Rudolf Antonius, Andrade, Raul J, Fortes, Cristina, Mosesso, Pasquale, Restani, Patrizia, Pizzo, Fabiola, Smeraldi, Camilla, Papaioannou, Adamantia, Wright, Matthew
Publicado 2018

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy

por Ye, Hui, Chen, Chaobo, Wu, Hanghang, Zheng, Kang, Martín-Adrados, Beatriz, Caparros, Esther, Francés, Rubén, Nelson, Leonard J., Gómez del Moral, Manuel, Asensio, Iris, Vaquero, Javier, Bañares, Rafael, Ávila, Matías A., Andrade, Raúl J., Isabel Lucena, M., Martínez-Chantar, Maria Luz, Reeves, Helen L., Masson, Steven, Blumberg, Richard S., Gracia-Sancho, Jordi, Nevzorova, Yulia A., Martínez-Naves, Eduardo, Cubero, Francisco Javier
Publicado 2022

Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation

por Gallego-Durán, Rocío, Ampuero, Javier, Pastor-Ramírez, Helena, Álvarez-Amor, Leticia, del Campo, Jose Antonio, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Cárdenas-García, Antonio, Pareja, Mª Jesús, Gato-Zambrano, Sheila, Millán, Raquel, del Carmen Rico, María, Luque-Sierra, Amparo, Gil-Gómez, Antonio, Rojas, Ángela, Muñoz-Hernández, Rocío, García-Lozano, María, Aller, Rocío, Andrade, Raúl J., García-Monzón, Carmelo, Andreola, Fausto, Martín, Francisco, Jalan, Rajiv, Romero-Gómez, Manuel
Publicado 2022

Beneficial effect of ursodeoxycholic acid in patients with acyl‐CoA oxidase 2 (ACOX2) deficiency–associated hypertransaminasemia

por Alonso‐Peña, Marta, Espinosa‐Escudero, Ricardo, Herraez, Elisa, Briz, Oscar, Cagigal, Maria Luisa, Gonzalez‐Santiago, Jesus M., Ortega‐Alonso, Aida, Fernandez‐Rodriguez, Conrado, Bujanda, Luis, Calvo Sanchez, Marta, D´Avola, Delia, Londoño, Maria‐Carlota, Diago, Moises, Fernandez‐Checa, Jose C., Garcia‐Ruiz, Carmen, Andrade, Raul J., Lammert, Frank, Prieto, Jesus, Crespo, Javier, Juamperez, Javier, Diaz‐Gonzalez, Alvaro, Monte, Maria J., Marin, Jose J. G.
Publicado 2022

Shared Genetic Risk Factors Across Carbamazepine‐Induced Hypersensitivity Reactions

por Nicoletti, Paola, Barrett, Sarah, McEvoy, Laurence, Daly, Ann K., Aithal, Guruprasad, Lucena, M. Isabel, Andrade, Raul J., Wadelius, Mia, Hallberg, Pär, Stephens, Camilla, Bjornsson, Einar S., Friedmann, Peter, Kainu, Kati, Laitinen, Tarja, Marson, Anthony, Molokhia, Mariam, Phillips, Elizabeth, Pichler, Werner, Romano, Antonino, Shear, Neil, Sills, Graeme, Tanno, Luciana K., Swale, Ashley, Floratos, Aris, Shen, Yufeng, Nelson, Matthew R., Watkins, Paul B., Daly, Mark J., Morris, Andrew P., Alfirevic, Ana, Pirmohamed, Munir
Publicado 2019

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans

por Ravindra, Kodihalli C., Vaidya, Vishal S., Wang, Zhenyu, Federspiel, Joel D., Virgen-Slane, Richard, Everley, Robert A., Grove, Jane I., Stephens, Camilla, Ocana, Mireia F., Robles-Díaz, Mercedes, Isabel Lucena, M., Andrade, Raul J., Atallah, Edmond, Gerbes, Alexander L., Weber, Sabine, Cortez-Pinto, Helena, Fowell, Andrew J., Hussaini, Hyder, Bjornsson, Einar S., Patel, Janisha, Stirnimann, Guido, Verma, Sumita, Elsharkawy, Ahmed M., Griffiths, William J. H., Hyde, Craig, Dear, James W., Aithal, Guruprasad P., Ramaiah, Shashi K.
Publicado 2023

Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for...

por Grove, Jane I., Stephens, Camilla, Lucena, M. Isabel, Andrade, Raúl J., Weber, Sabine, Gerbes, Alexander, Bjornsson, Einar S., Stirnimann, Guido, Daly, Ann K., Hackl, Matthias, Khamina-Kotisch, Kseniya, Marin, Jose J. G., Monte, Maria J., Paciga, Sara A., Lingaya, Melanie, Forootan, Shiva S., Goldring, Christopher E. P., Poetz, Oliver, Lombaard, Rudolf, Stege, Alexandra, Bjorrnsson, Helgi K., Robles-Diaz, Mercedes, Li, Dingzhou, Tran, Thi Dong Binh, Ramaiah, Shashi K., Samodelov, Sophia L., Kullak-Ublick, Gerd A., Aithal, Guruprasad P.
Publicado 2023

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

por Barbier-Torres, Lucía, Iruzubieta, Paula, Fernández-Ramos, David, Delgado, Teresa C., Taibo, Daniel, Guitiérrez-de-Juan, Virginia, Varela-Rey, Marta, Azkargorta, Mikel, Navasa, Nicolas, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, Simon, Jorge, Lopitz-Otsoa, Fernando, Lachiondo-Ortega, Sofia, Crespo, Javier, Masson, Steven, McCain, Misti Vanette, Villa, Erica, Reeves, Helen, Elortza, Felix, Lucena, Maria Isabel, Hernández-Alvarez, Maria Isabel, Zorzano, Antonio, Andrade, Raúl J., Lu, Shelly C., Mato, José M., Anguita, Juan, Rincón, Mercedes, Martínez-Chantar, María Luz
Publicado 2017

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

por Rodríguez-Agudo, Rubén, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Fernández-Tussy, Pablo, Fernández-Ramos, David, Lachiondo-Ortega, Sofía, González-Recio, Irene, Gil-Pitarch, Clàudia, Mercado-Gómez, María, Morán, Laura, Bizkarguenaga, Maider, Lopitz-Otsoa, Fernando, Petrov, Petar, Bravo, Miren, Van Liempd, Sebastiaan Martijn, Falcon-Perez, Juan Manuel, Zabala-Letona, Amaia, Carracedo, Arkaitz, Castell, Jose Vicente, Jover, Ramiro, Martínez-Cruz, Luis Alfonso, Delgado, Teresa Cardoso, Cubero, Francisco Javier, Lucena, María Isabel, Andrade, Raúl Jesús, Mabe, Jon, Simón, Jorge, Martínez-Chantar, María Luz
Publicado 2022