pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

por Pires, Douglas E. V., Blundell, Tom L., Ascher, David B.
Publicado 2015

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

por Pires, Douglas E. V., Blundell, Tom L., Ascher, David B.
Publicado 2016

dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction

por Kaminskas, Lisa M., Pires, Douglas E. V., Ascher, David B.
Publicado 2019

epitope1D: accurate taxonomy-aware B-cell linear epitope prediction

por da Silva, Bruna Moreira, Ascher, David B, Pires, Douglas E V
Publicado 2023

mCSM-membrane: predicting the effects of mutations on transmembrane proteins

por Pires, Douglas E V, Rodrigues, Carlos H M, Ascher, David B
Publicado 2020

DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations

por Rodrigues, Carlos H.M., Pires, Douglas E.V., Ascher, David B.
Publicado 2020

mmCSM-PPI: predicting the effects of multiple point mutations on protein–protein interactions

por Rodrigues, Carlos H M, Pires, Douglas E V, Ascher, David B
Publicado 2021

pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures

por Velloso, João Paulo L, Ascher, David B, Pires, Douglas E V
Publicado 2021

Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2

por Aljarf, Raghad, Shen, Mengyuan, Pires, Douglas E. V., Ascher, David B.
Publicado 2022

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

por Pires, Douglas E. V., Chen, Jing, Blundell, Tom L., Ascher, David B.
Publicado 2016

Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance

por Pandurangan, Arun Prasad, Ascher, David B., Thomas, Sherine E., Blundell, Tom L.
Publicado 2017

SDM: a server for predicting effects of mutations on protein stability

por Pandurangan, Arun Prasad, Ochoa-Montaño, Bernardo, Ascher, David B., Blundell, Tom L.
Publicado 2017

Estimating tuberculosis drug resistance amplification rates in high-burden settings

por Karmakar, Malancha, Ragonnet, Romain, Ascher, David B., Trauer, James M., Denholm, Justin T.
Publicado 2022

cropCSM: designing safe and potent herbicides with graph-based signatures

por Pires, Douglas E V, Stubbs, Keith A, Mylne, Joshua S, Ascher, David B
Publicado 2022

Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures

por Pan, Qisheng, Nguyen, Thanh Binh, Ascher, David B, Pires, Douglas E V
Publicado 2022

Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis

por Portelli, Stephanie, Phelan, Jody E., Ascher, David B., Clark, Taane G., Furnham, Nicholas
Publicado 2018

mCSM-PPI2: predicting the effects of mutations on protein–protein interactions

por Rodrigues, Carlos H M, Myung, Yoochan, Pires, Douglas E V, Ascher, David B
Publicado 2019

Structure guided prediction of Pyrazinamide resistance mutations in pncA

por Karmakar, Malancha, Rodrigues, Carlos H. M., Horan, Kristy, Denholm, Justin T., Ascher, David B.
Publicado 2020

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

por Blaszczyk, Michal, Harmer, Nicholas J., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.
Publicado 2015

ProCarbDB: a database of carbohydrate-binding proteins

por Copoiu, Liviu, Torres, Pedro H M, Ascher, David B, Blundell, Tom L, Malhotra, Sony
Publicado 2020