Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism

por Gründemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Käufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J., Schabbauer, Gernot, Gruber, Christian W.
Publicado 2013

Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties

por Vernen, Felicitas, Harvey, Peta J., Dias, Susana A., Veiga, Ana Salomé, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole, Troeira Henriques, Sónia
Publicado 2019

Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity

por Sang, Jianrong, Kulkarni, Ketav, Watson, Gabrielle M., Ma, Xiuquan, Craik, David J., Henriques, Sónia T., Poth, Aaron G., Benfield, Aurélie H., Wilce, Jacqueline A.
Publicado 2019

Characterization of Synthetic Tf2 as a Na(V)1.3 Selective Pharmacological Probe

por Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina, Durek, Thomas
Publicado 2020

Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells

por Lawrence, Nicole, Philippe, Grégoire J.-B., Harvey, Peta J., Condon, Nicholas D., Benfield, Aurélie H., Cheneval, Olivier, Craik, David J., Troeira Henriques, Sónia
Publicado 2020

Molecular Grafting onto a Stable Framework Yields Novel Cyclic Peptides for the Treatment of Multiple Sclerosis

por Wang, Conan K., Gruber, Christian W., Cemazar, Maša, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C., Craik, David J.
Publicado 2013

Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics

por Jin, Ai-Hua, Brandstaetter, Hemma, Nevin, Simon T, Tan, Chia Chia, Clark, Richard J, Adams, David J, Alewood, Paul F, Craik, David J, Daly, Norelle L
Publicado 2007

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR

por El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker, Nicke, Annette
Publicado 2019

Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes

por Pinto, Meri Emili F., Chan, Lai Yue, Koehbach, Johannes, Devi, Seema, Gründemann, Carsten, Gruber, Christian W., Gomes, Mario, Bolzani, Vanderlan S., Cilli, Eduardo Maffud, Craik, David J.
Publicado 2021

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

por Dias, Susana A, Pinto, Sandra N, Silva-Herdade, Ana S, Cheneval, Olivier, Craik, David J, Coutinho, Ana, Castanho, Miguel A R B, Henriques, Sónia T, Veiga, Ana Salomé
Publicado 2022

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

por Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J, Anderson, Marilyn A
Publicado 2018

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

por Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas, Craik, David J.
Publicado 2020

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

por Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam, Craik, David J.
Publicado 2022

Cystine Knot Peptides with Tuneable Activity and Mechanism

por Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J., de Veer, Simon J.
Publicado 2022

Novel Inhibitor Cystine Knot Peptides from Momordica charantia

por He, Wen-Jun, Chan, Lai Yue, Clark, Richard J., Tang, Jun, Zeng, Guang-Zhi, Franco, Octavio L., Cantacessi, Cinzia, Craik, David J., Daly, Norelle L., Tan, Ning-Hua
Publicado 2013

α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA(B) receptors

por Castro, Joel, Harrington, Andrea M, Garcia-Caraballo, Sonia, Maddern, Jessica, Grundy, Luke, Zhang, Jingming, Page, Guy, Miller, Paul E, Craik, David J, Adams, David J, Brierley, Stuart M
Publicado 2017

Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide

por Jackson, Mark A., Yap, Kuok, Poth, Aaron G., Gilding, Edward K., Swedberg, Joakim E., Poon, Simon, Qu, Haiou, Durek, Thomas, Harris, Karen, Anderson, Marilyn A., Craik, David J.
Publicado 2019

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain

por Muratspahić, Edin, Tomašević, Nataša, Koehbach, Johannes, Duerrauer, Leopold, Hadžić, Seid, Castro, Joel, Schober, Gudrun, Sideromenos, Spyridon, Clark, Richard J., Brierley, Stuart M., Craik, David J., Gruber, Christian W.
Publicado 2021

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples

por Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J., Gruber, Christian W.
Publicado 2023

Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens

por Hansen, Ida K. Ø., Isaksson, Johan, Poth, Aaron G., Hansen, Kine Ø., Andersen, Aaron J. C., Richard, Céline S. M., Blencke, Hans-Matti, Stensvåg, Klara, Craik, David J., Haug, Tor
Publicado 2020