OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic

por Curtis, Helen J, MacKenna, Brian, Wiedemann, Milan, Fisher, Louis, Croker, Richard, Morton, Caroline E, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian CJ, Hickman, George, Evans, David, Ward, Tom, Davy, Simon, Hulme, William J, Macdonald, Orla, Conibere, Robin, Lewis, Tom, Myers, Martin, Wanninayake, Shamila, Collison, Kiren, Drury, Charles, Samuel, Miriam, Sood, Harpreet, Cipriani, Andrea, Fazel, Seena, Sharma, Manuj, Baqir, Wasim, Bates, Chris, Parry, John, Goldacre, Ben
Publicado 2023

Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

por Chang, Hsiao-Han, Wesolowski, Amy, Sinha, Ipsita, Jacob, Christopher G, Mahmud, Ayesha, Uddin, Didar, Zaman, Sazid Ibna, Hossain, Md Amir, Faiz, M Abul, Ghose, Aniruddha, Sayeed, Abdullah Abu, Rahman, M Ridwanur, Islam, Akramul, Karim, Mohammad Jahirul, Rezwan, M Kamar, Shamsuzzaman, Abul Khair Mohammad, Jhora, Sanya Tahmina, Aktaruzzaman, M M, Drury, Eleanor, Gonçalves, Sonia, Kekre, Mihir, Dhorda, Mehul, Vongpromek, Ranitha, Miotto, Olivo, Engø-Monsen, Kenth, Kwiatkowski, Dominic, Maude, Richard J, Buckee, Caroline
Publicado 2019

The World Health Network: a global citizens' initiative

por Bar-Yam, Yaneer, Gurdasani, Deepti, Baker, Michael G, Scally, Gabriel, George, Simone, Kvalsvig, Amanda, Fhaoláin, Sinéad Ní, Chiou, Shu-Ti, Drury, John, Duckett, Stephen, Ding, Eric L, Gershenson, Carlos, Gibson, Christine, Greenhalgh, Trisha, Hamdy, Adam, Hyde, Zoë, James, Tiffany, Jimenez, Jose L, McKee, Martin, Michie, Susan, Pagel, Christina, Philippe, Cecile, Prather, Kim, Raina, Sunil K, Ricciardi, Walter, Rubin, Meir, Ryan, Tomás, Schneider, Matthias F, Staines, Anthony, West, Robert, Ziauddeen, Hisham
Publicado 2021

SARS-CoV-2 seroprevalence rates of children seeking medical care in Louisiana during the state stay at home order

por Dietrich, Monika L., Norton, Elizabeth B., Elliott, Debra, Smira, Ashley R., Raviv, Ofek, Sasson, Daniel J., Monk, Chandler H., Michael, Madalyn L., Rogers, Nathaniel, Rouelle, Julie A., Bond, Nell G., Aime-Marcelin, Kéren, Prystowsky, Alisha, Kemnitz, Rebecca, Sarma, Arunava, Himmelfarb, Sarah Talia, Sharma, Neha, Stone, Addison E., Craver, Randall, Lindrose, Alyssa R., Smitley, Leslie A., Uddo, Robert B., Myers, Leann, Drury, Stacy S., Schieffelin, John S., Robinson, James E., Zwezdaryk, Kevin J.
Publicado 2021

Malaria protection due to sickle haemoglobin depends on parasite genotype

por Band, Gavin, Leffler, Ellen M., Jallow, Muminatou, Sisay-Joof, Fatoumatta, Ndila, Carolyne M., Macharia, Alexander W., Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Nguyen, Thuy, Gonçalves, Sónia, Ariani, Cristina V., Stalker, Jim, Pearson, Richard D., Amato, Roberto, Drury, Eleanor, Sirugo, Giorgio, d’Alessandro, Umberto, Bojang, Kalifa A., Marsh, Kevin, Peshu, Norbert, Saelens, Joseph W., Diakité, Mahamadou, Taylor, Steve M., Conway, David J., Williams, Thomas N., Rockett, Kirk A., Kwiatkowski, Dominic P.
Publicado 2021

Interventions to promote physical distancing behaviour during infectious disease pandemics or epidemics: A systematic review

por Epton, Tracy, Ghio, Daniela, Ballard, Lisa M., Allen, Sarah F., Kassianos, Angelos P., Hewitt, Rachael, Swainston, Katherine, Fynn, Wendy Irene, Rowland, Vickie, Westbrook, Juliette, Jenkinson, Elizabeth, Morrow, Alison, McGeechan, Grant J., Stanescu, Sabina, Yousuf, Aysha A., Sharma, Nisha, Begum, Suhana, Karasouli, Eleni, Scanlan, Daniel, Shorter, Gillian W., Arden, Madelynne A., Armitage, Christopher J., O'Connor, Daryl B., Kamal, Atiya, McBride, Emily, Swanson, Vivien, Hart, Jo, Byrne-Davis, Lucie, Chater, Angel, Drury, John
Publicado 2022

Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

por Basu, S., Shukron, O., Hall, D., Parutto, P., Ponjavic, A., Shah, D., Boucher, W., Lando, D., Zhang, W., Reynolds, N., Sober, L. H., Jartseva, A., Ragheb, R., Ma, X., Cramard, J., Floyd, R., Balmer, J., Drury, T. A., Carr, A. R., Needham, L.-M., Aubert, A., Communie, G., Gor, K., Steindel, M., Morey, L., Blanco, E., Bartke, T., Di Croce, L., Berger, I., Schaffitzel, C., Lee, S. F., Stevens, T. J., Klenerman, D., Hendrich, B. D., Holcman, D., Laue, E. D.
Publicado 2023

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

por Girgis, Sophia T., Adika, Edem, Nenyewodey, Felix E., Senoo Jnr, Dodzi K., Ngoi, Joyce M., Bandoh, Kukua, Lorenz, Oliver, van de Steeg, Guus, Harrott, Alexandria J. R., Nsoh, Sebastian, Judge, Kim, Pearson, Richard D., Almagro-Garcia, Jacob, Saiid, Samirah, Atampah, Solomon, Amoako, Enock K., Morang’a, Collins M., Asoala, Victor, Adjei, Elrmion S., Burden, William, Roberts-Sengier, William, Drury, Eleanor, Pierce, Megan L., Gonçalves, Sónia, Awandare, Gordon A., Kwiatkowski, Dominic P., Amenga-Etego, Lucas N., Hamilton, William L.
Publicado 2023

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

por Chou, Angela, Froio, Danielle, Nagrial, Adnan M, Parkin, Ashleigh, Murphy, Kendelle J, Chin, Venessa T, Wohl, Dalia, Steinmann, Angela, Stark, Rhys, Drury, Alison, Walters, Stacey N, Vennin, Claire, Burgess, Andrew, Pinese, Mark, Chantrill, Lorraine A, Cowley, Mark J, Molloy, Timothy J, Waddell, Nicola, Johns, Amber, Grimmond, Sean M, Chang, David K, Biankin, Andrew V, Sansom, Owen J, Morton, Jennifer P, Grey, Shane T, Cox, Thomas R, Turchini, John, Samra, Jaswinder, Clarke, Stephen J, Timpson, Paul, Gill, Anthony J, Pajic, Marina
Publicado 2018

The UK needs a sustainable strategy for COVID-19

por Gurdasani, Deepti, Bear, Laura, Bogaert, Debby, Burgess, Rochelle A, Busse, Reinhard, Cacciola, Roberto, Charpak, Yves, Colbourn, Tim, Drury, John, Friston, Karl, Gallo, Valentina, Goldman, Lynn R, Greenhalgh, Trisha, Hyde, Zoë, Kuppalli, Krutika, Majumder, Maimuna S, Martin-Moreno, Jose M, McKee, Martin, Michie, Susan, Mossialos, Elias, Nouri, Ali, Pagel, Christina, Pimenta, Dominic, Popescu, Saskia, Priesemann, Viola, Rasmussen, Angela L, Reicher, Stephen, Ricciardi, Walter, Rice, Ken, Silver, Joshua, Smith, Tara C, Wenham, Clare, West, Robert, Yamey, Gavin, Yates, Christian, Ziauddeen, Hisham
Publicado 2020

Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through...

por Fisher, Louis, Curtis, Helen J, Croker, Richard, Wiedemann, Milan, Speed, Victoria, Wood, Christopher, Brown, Andrew, Hopcroft, Lisa EM, Higgins, Rose, Massey, Jon, Inglesby, Peter, Morton, Caroline E, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Hickman, George, Macdonald, Orla, Lewis, Tom, Wood, Marion, Myers, Martin, Samuel, Miriam, Conibere, Robin, Baqir, Wasim, Sood, Harpreet, Drury, Charles, Collison, Kiren, Bates, Chris, Evans, David, Dillingham, Iain, Ward, Tom, Davy, Simon, Smith, Rebecca M, Hulme, William, Green, Amelia, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, MacKenna, Brian, Goldacre, Ben
Publicado 2023

Genomic analysis of local variation and recent evolution in Plasmodium vivax

por Pearson, Richard D, Amato, Roberto, Auburn, Sarah, Miotto, Olivo, Almagro-Garcia, Jacob, Amaratunga, Chanaki, Suon, Seila, Mao, Sivanna, Noviyanti, Rintis, Trimarsanto, Hidayat, Marfurt, Jutta, Anstey, Nicholas M, William, Timothy, Boni, Maciej F, Dolecek, Christiane, Hien, Tinh Tran, White, Nicholas J, Michon, Pascal, Siba, Peter, Tavul, Livingstone, Harrison, Gabrielle, Barry, Alyssa, Mueller, Ivo, Ferreira, Marcelo U, Karunaweera, Nadira, Randrianarivelojosia, Milijaona, Gao, Qi, Hubbart, Christina, Hart, Lee, Jeffery, Ben, Drury, Eleanor, Mead, Daniel, Kekre, Mihir, Campino, Susana, Manske, Magnus, Cornelius, Victoria J, MacInnis, Bronwyn, Rockett, Kirk A, Miles, Alistair, Rayner, Julian C, Fairhurst, Rick M, Nosten, Francois, Price, Ric N, Kwiatkowski, Dominic P
Publicado 2016

Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

por Hamilton, William L, Amato, Roberto, van der Pluijm, Rob W, Jacob, Christopher G, Quang, Huynh Hong, Thuy-Nhien, Nguyen Thanh, Hien, Tran Tinh, Hongvanthong, Bouasy, Chindavongsa, Keobouphaphone, Mayxay, Mayfong, Huy, Rekol, Leang, Rithea, Huch, Cheah, Dysoley, Lek, Amaratunga, Chanaki, Suon, Seila, Fairhurst, Rick M, Tripura, Rupam, Peto, Thomas J, Sovann, Yok, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Chau, Nguyen Hoang, Imwong, Mallika, Dhorda, Mehul, Vongpromek, Ranitha, Chan, Xin Hui S, Maude, Richard J, Pearson, Richard D, Nguyen, T, Rockett, Kirk, Drury, Eleanor, Gonçalves, Sónia, White, Nicholas J, Day, Nicholas P, Kwiatkowski, Dominic P, Dondorp, Arjen M, Miotto, Olivo
Publicado 2019

CHD2 variants are a risk factor for photosensitivity in epilepsy

por Galizia, Elizabeth C., Myers, Candace T., Leu, Costin, de Kovel, Carolien G. F., Afrikanova, Tatiana, Cordero-Maldonado, Maria Lorena, Martins, Teresa G., Jacmin, Maxime, Drury, Suzanne, Krishna Chinthapalli, V., Muhle, Hiltrud, Pendziwiat, Manuela, Sander, Thomas, Ruppert, Ann-Kathrin, Møller, Rikke S., Thiele, Holger, Krause, Roland, Schubert, Julian, Lehesjoki, Anna-Elina, Nürnberg, Peter, Lerche, Holger, Palotie, Aarno, Coppola, Antonietta, Striano, Salvatore, Gaudio, Luigi Del, Boustred, Christopher, Schneider, Amy L., Lench, Nicholas, Jocic-Jakubi, Bosanka, Covanis, Athanasios, Capovilla, Giuseppe, Veggiotti, Pierangelo, Piccioli, Marta, Parisi, Pasquale, Cantonetti, Laura, Sadleir, Lynette G., Mullen, Saul A., Berkovic, Samuel F., Stephani, Ulrich, Helbig, Ingo, Crawford, Alexander D., Esguerra, Camila V., Kasteleijn-Nolst Trenité, Dorothee G. A., Koeleman, Bobby P. C., Mefford, Heather C., Scheffer, Ingrid E., Sisodiya, Sanjay M.
Publicado 2015

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

por Manske, Magnus, Miotto, Olivo, Campino, Susana, Auburn, Sarah, Almagro-Garcia, Jacob, Maslen, Gareth, O’Brien, Jack, Djimde, Abdoulaye, Doumbo, Ogobara, Zongo, Issaka, Ouedraogo, Jean-Bosco, Michon, Pascal, Mueller, Ivo, Siba, Peter, Nzila, Alexis, Borrmann, Steffen, Kiara, Steven M., Marsh, Kevin, Jiang, Hongying, Su, Xin-Zhuan, Amaratunga, Chanaki, Fairhurst, Rick, Socheat, Duong, Nosten, Francois, Imwong, Mallika, White, Nicholas J., Sanders, Mandy, Anastasi, Elisa, Alcock, Dan, Drury, Eleanor, Oyola, Samuel, Quail, Michael A., Turner, Daniel J., Rubio, Valentin Ruano, Jyothi, Dushyanth, Amenga-Etego, Lucas, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Sutherland, Colin, Roper, Cally, Mangano, Valentina, Modiano, David, Tan, John C., Ferdig, Michael T., Amambua-Ngwa, Alfred, Conway, David J., Takala-Harrison, Shannon, Plowe, Christopher V., Rayner, Julian C., Rockett, Kirk A., Clark, Taane G., Newbold, Chris I., Berriman, Matthew, MacInnis, Bronwyn, Kwiatkowski, Dominic P.
Publicado 2012

Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C

por Fink, Ericka L., Robertson, Courtney L., Wainwright, Mark S., Roa, Juan D., Lovett, Marlina E., Stulce, Casey, Yacoub, Mais, Potera, Renee M., Zivick, Elizabeth, Holloway, Adrian, Nagpal, Ashish, Wellnitz, Kari, Czech, Theresa, Even, Katelyn M., Brunow de Carvalho, Werther, Rodriguez, Isadora Souza, Schwartz, Stephanie P., Walker, Tracie C., Campos-Miño, Santiago, Dervan, Leslie A., Geneslaw, Andrew S., Sewell, Taylor B., Pryce, Patrice, Silver, Wendy G., Lin, Jieru Egeria, Vargas, Wendy S., Topjian, Alexis, Alcamo, Alicia M., McGuire, Jennifer L., Domínguez Rojas, Jesus Angel, Muñoz, Jaime Tasayco, Hong, Sue J., Muller, William J., Doerfler, Matthew, Williams, Cydni N., Drury, Kurt, Bhagat, Dhristie, Nelson, Aaron, Price, Dana, Dapul, Heda, Santos, Laura, Kahoud, Robert, Francoeur, Conall, Appavu, Brian, Guilliams, Kristin P., Agner, Shannon C., Walson, Karen H., Rasmussen, Lindsey, Janas, Anna, Ferrazzano, Peter, Farias-Moeller, Raquel, Snooks, Kellie C., Chang, Chung-Chou H., Yun, James, Schober, Michelle E.
Publicado 2022

A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria

por Trimarsanto, Hidayat, Amato, Roberto, Pearson, Richard D., Sutanto, Edwin, Noviyanti, Rintis, Trianty, Leily, Marfurt, Jutta, Pava, Zuleima, Echeverry, Diego F., Lopera-Mesa, Tatiana M., Montenegro, Lidia M., Tobón-Castaño, Alberto, Grigg, Matthew J., Barber, Bridget, William, Timothy, Anstey, Nicholas M., Getachew, Sisay, Petros, Beyene, Aseffa, Abraham, Assefa, Ashenafi, Rahim, Awab G., Chau, Nguyen H., Hien, Tran T., Alam, Mohammad S., Khan, Wasif A., Ley, Benedikt, Thriemer, Kamala, Wangchuck, Sonam, Hamedi, Yaghoob, Adam, Ishag, Liu, Yaobao, Gao, Qi, Sriprawat, Kanlaya, Ferreira, Marcelo U., Laman, Moses, Barry, Alyssa, Mueller, Ivo, Lacerda, Marcus V. G., Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Mohammed, Rezika, Yilma, Daniel, Pereira, Dhelio B., Espino, Fe E. J., Chu, Cindy S., Vélez, Iván D., Namaik-larp, Chayadol, Villegas, Maria F., Green, Justin A., Koh, Gavin, Rayner, Julian C., Drury, Eleanor, Gonçalves, Sónia, Simpson, Victoria, Miotto, Olivo, Miles, Alistair, White, Nicholas J., Nosten, Francois, Kwiatkowski, Dominic P., Price, Ric N., Auburn, Sarah
Publicado 2022

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

por Miotto, Olivo, Almagro-Garcia, Jacob, Manske, Magnus, MacInnis, Bronwyn, Campino, Susana, Rockett, Kirk A, Amaratunga, Chanaki, Lim, Pharath, Suon, Seila, Sreng, Sokunthea, Anderson, Jennifer M, Duong, Socheat, Nguon, Chea, Chuor, Char Meng, Saunders, David, Se, Youry, Lon, Chantap, Fukuda, Mark M, Amenga-Etego, Lucas, Hodgson, Abraham VO, Asoala, Victor, Imwong, Mallika, Takala-Harrison, Shannon, Nosten, Francois, Su, Xin-zhuan, Ringwald, Pascal, Ariey, Frédéric, Dolecek, Christiane, Hien, Tran Tinh, Boni, Maciej F, Thai, Cao Quang, Amambua-Ngwa, Alfred, Conway, David J, Djimdé, Abdoulaye A, Doumbo, Ogobara K, Zongo, Issaka, Ouedraogo, Jean-Bosco, Alcock, Daniel, Drury, Eleanor, Auburn, Sarah, Koch, Oliver, Sanders, Mandy, Hubbart, Christina, Maslen, Gareth, Ruano-Rubio, Valentin, Jyothi, Dushyanth, Miles, Alistair, O’Brien, John, Gamble, Chris, Oyola, Samuel O, Rayner, Julian C, Newbold, Chris I, Berriman, Matthew, Spencer, Chris CA, McVean, Gilean, Day, Nicholas P, White, Nicholas J, Bethell, Delia, Dondorp, Arjen M, Plowe, Christopher V, Fairhurst, Rick M, Kwiatkowski, Dominic P
Publicado 2013

Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015

por Kerber, Romy, Krumkamp, Ralf, Diallo, Boubacar, Jaeger, Anna, Rudolf, Martin, Lanini, Simone, Bore, Joseph Akoi, Koundouno, Fara Raymond, Becker-Ziaja, Beate, Fleischmann, Erna, Stoecker, Kilian, Meschi, Silvia, Mély, Stéphane, Newman, Edmund N. C., Carletti, Fabrizio, Portmann, Jasmine, Korva, Misa, Wolff, Svenja, Molkenthin, Peter, Kis, Zoltan, Kelterbaum, Anne, Bocquin, Anne, Strecker, Thomas, Fizet, Alexandra, Castilletti, Concetta, Schudt, Gordian, Ottowell, Lisa, Kurth, Andreas, Atkinson, Barry, Badusche, Marlis, Cannas, Angela, Pallasch, Elisa, Bosworth, Andrew, Yue, Constanze, Pályi, Bernadett, Ellerbrok, Heinz, Kohl, Claudia, Oestereich, Lisa, Logue, Christopher H., Lüdtke, Anja, Richter, Martin, Ngabo, Didier, Borremans, Benny, Becker, Dirk, Gryseels, Sophie, Abdellati, Saïd, Vermoesen, Tine, Kuisma, Eeva, Kraus, Annette, Liedigk, Britta, Maes, Piet, Thom, Ruth, Duraffour, Sophie, Diederich, Sandra, Hinzmann, Julia, Afrough, Babak, Repits, Johanna, Mertens, Marc, Vitoriano, Inês, Bah, Amadou, Sachse, Andreas, Boettcher, Jan Peter, Wurr, Stephanie, Bockholt, Sabrina, Nitsche, Andreas, Županc, Tatjana Avšič, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Raoul, Herve, Carroll, Miles W., De Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Koivogui, Lamine, Magassouba, N'Faly, Keïta, Sakoba, Drury, Patrick, Gurry, Cèline, Formenty, Pierre, May, Jürgen, Gabriel, Martin, Wölfel, Roman, Günther, Stephan, Di Caro, Antonino
Publicado 2016

Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015—A Retrospective Observational Study

por Kerber, Romy, Lorenz, Eva, Duraffour, Sophie, Sissoko, Daouda, Rudolf, Martin, Jaeger, Anna, Cisse, Sekou Ditinn, Camara, Alseny-Modet, Miranda, Osvaldo, Castro, Carlos M, Akoi Bore, Joseph, Raymond Koundouno, Fara, Repits, Johanna, Afrough, Babak, Becker-Ziaja, Beate, Hinzmann, Julia, Mertens, Marc, Vitoriano, Ines, Hugh Logue, Christopher, Böttcher, Jan-Peter, Pallasch, Elisa, Sachse, Andreas, Bah, Amadou, Cabeza-Cabrerizo, Mar, Nitzsche, Katja, Kuisma, Eeva, Michel, Janine, Holm, Tobias, Zekeng, Elsa Gayle, Cowley, Lauren A, Garcia-Dorival, Isabel, Hetzelt, Nicole, Baum, Jonathan Hans Josef, Portmann, Jasmine, Carter, Lisa, Yenamaberhan, Rahel Lemma, Camino, Alvaro, Enkirch, Theresa, Singethan, Katrin, Meisel, Sarah, Mazzarelli, Antonio, Kosgei, Abigail, Kafetzopoulou, Liana, Rickett, Natasha Y, Patrono, Livia Victoria, Ghebreghiorghis, Luam, Arnold, Ulrike, Colin, Géraldine, Juchet, Sylvain, Marchal, Claire Levy, Kolie, Jacques Seraphin, Beavogui, Abdoul Habib, Wurr, Stephanie, Bockholt, Sabrina, Krumkamp, Ralf, May, Jürgen, Stoecker, Kilian, Fleischmann, Erna, Ippolito, Giuseppe, Carroll, Miles W, Koivogui, Lamine, Magassouba, N’Faly, Keita, Sakoba, Gurry, Céline, Drury, Patrick, Diallo, Boubacar, Formenty, Pierre, Wölfel, Roman, Caro, Antonino Di, Gabriel, Martin, Anglaret, Xavier, Malvy, Denis, Günther, Stephan
Publicado 2019