Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk?

por Gottesman, Omri, Drill, Esther, Lotay, Vaneet, Bottinger, Erwin, Peter, Inga
Publicado 2012

Implementation and utilization of genetic testing in personalized medicine

por Abul-Husn, Noura S, Owusu Obeng, Aniwaa, Sanderson, Saskia C, Gottesman, Omri, Scott, Stuart A
Publicado 2014

Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians

por Tayo, Bamidele O., Kramer, Holly, Salako, Babatunde L., Gottesman, Omri, McKenzie, Colin A., Ogunniyi, Adesola, Bottinger, Erwin P., Cooper, Richard S.
Publicado 2012

Erratum to: Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians

por Tayo, Bamidele O., Kramer, Holly, Salako, Babatunde L., Gottesman, Omri, McKenzie, Colin A., Ogunniyi, Adesola, Bottinger, Erwin P., Cooper, Richard S.
Publicado 2014

Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine

por Tayo, Bamidele O., Teil, Marie, Tong, Liping, Qin, Huaizhen, Khitrov, Gregory, Zhang, Weijia, Song, Quinbin, Gottesman, Omri, Zhu, Xiaofeng, Pereira, Alexandre C., Cooper, Richard S., Bottinger, Erwin P.
Publicado 2011

Physician Attitudes toward Adopting Genome-Guided Prescribing through Clinical Decision Support

por Overby, Casey Lynnette, Erwin, Angelika Ludtke, Abul-Husn, Noura S., Ellis, Stephen B., Scott, Stuart A., Obeng, Aniwaa Owusu, Kannry, Joseph L., Hripcsak, George, Bottinger, Erwin P., Gottesman, Omri
Publicado 2014

Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry

por Wenric, Stephane, Jeff, Janina M., Joseph, Thomas, Yee, Muh-Ching, Belbin, Gillian M., Owusu Obeng, Aniwaa, Ellis, Stephen B., Bottinger, Erwin P., Gottesman, Omri, Levin, Matthew A., Kenny, Eimear E.
Publicado 2020

Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease

por Horowitz, Julie E., Warner, Neil, Staples, Jeffrey, Crowley, Eileen, Gosalia, Nehal, Murchie, Ryan, Van Hout, Cristopher, Fiedler, Karoline, Welch, Gabriel, King, Alejandra Klauer, Reid, Jeffrey G., Overton, John D., Baras, Aris, Shuldiner, Alan R., Griffiths, Anne, Gottesman, Omri, Muise, Aleixo M., Gonzaga-Jauregui, Claudia
Publicado 2021

Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs

por Below, Jennifer E., Parra, Esteban J., Gamazon, Eric R., Torres, Jason, Krithika, S., Candille, Sophie, Lu, Yingchang, Manichakul, Ani, Peralta-Romero, Jesus, Duan, Qing, Li, Yun, Morris, Andrew P., Gottesman, Omri, Bottinger, Erwin, Wang, Xin-Qun, Taylor, Kent D., Ida Chen, Y.-D., Rotter, Jerome I., Rich, Stephen S., Loos, Ruth J. F., Tang, Hua, Cox, Nancy J., Cruz, Miguel, Hanis, Craig L., Valladares-Salgado, Adan
Publicado 2016

Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm

por Joo, Yoonjung Yoonie, Pacheco, Jennifer A., Thompson, William K., Rasmussen-Torvik, Laura J., Rasmussen, Luke V., Lin, Frederick T. J., de Andrade, Mariza, Borthwick, Kenneth M., Bottinger, Erwin, Cagan, Andrew, Carrell, David S., Denny, Joshua C., Ellis, Stephen B., Gottesman, Omri, Linneman, James G., Pathak, Jyotishman, Peissig, Peggy L., Shang, Ning, Tromp, Gerard, Veerappan, Annapoorani, Smith, Maureen E., Chisholm, Rex L., Gawron, Andrew J., Hayes, M. Geoffrey, Kho, Abel N.
Publicado 2023

ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow

por Borthwick, Kenneth M, Smelser, Diane T, Bock, Jonathan A, Elmore, James R, Ryer, Evan J, Ye, Zi, Pacheco, Jennifer A., Carrell, David S., Michalkiewicz, Michael, Thompson, William K, Pathak, Jyotishman, Bielinski, Suzette J, Denny, Joshua C, Linneman, James G, Peissig, Peggy L, Kho, Abel N, Gottesman, Omri, Parmar, Harpreet, Kullo, Iftikhar J, McCarty, Catherine A, Böttinger, Erwin P, Larson, Eric B, Jarvik, Gail P, Harley, John B, Bajwa, Tanvir, Franklin, David P, Carey, David J, Kuivaniemi, Helena, Tromp, Gerard
Publicado 2015

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

por Gottesman, Omri, Kuivaniemi, Helena, Tromp, Gerard, Faucett, W. Andrew, Li, Rongling, Manolio, Teri A., Sanderson, Saskia C., Kannry, Joseph, Zinberg, Randi, Basford, Melissa A., Brilliant, Murray, Carey, David J., Chisholm, Rex L., Chute, Christopher G., Connolly, John J., Crosslin, David, Denny, Joshua C., Gallego, Carlos J., Haines, Jonathan L., Hakonarson, Hakon, Harley, John, Jarvik, Gail P., Kohane, Isaac, Kullo, Iftikhar J., Larson, Eric B., McCarty, Catherine, Ritchie, Marylyn D., Roden, Dan M., Smith, Maureen E., Böttinger, Erwin P., Williams, Marc S.
Publicado 2013

Genetic identification of a common collagen disease in Puerto Ricans via identity-by-descent mapping in a health system

por Belbin, Gillian Morven, Odgis, Jacqueline, Sorokin, Elena P, Yee, Muh-Ching, Kohli, Sumita, Glicksberg, Benjamin S, Gignoux, Christopher R, Wojcik, Genevieve L, Van Vleck, Tielman, Jeff, Janina M, Linderman, Michael, Schurmann, Claudia, Ruderfer, Douglas, Cai, Xiaoqiang, Merkelson, Amanda, Justice, Anne E, Young, Kristin L, Graff, Misa, North, Kari E, Peters, Ulrike, James, Regina, Hindorff, Lucia, Kornreich, Ruth, Edelmann, Lisa, Gottesman, Omri, Stahl, Eli EA, Cho, Judy H, Loos, Ruth JF, Bottinger, Erwin P, Nadkarni, Girish N, Abul-Husn, Noura S, Kenny, Eimear E
Publicado 2017

Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network

por Gallego, Carlos J., Burt, Amber, Sundaresan, Agnes S., Ye, Zi, Shaw, Christopher, Crosslin, David R., Crane, Paul K., Fullerton, S. Malia, Hansen, Kris, Carrell, David, Kuivaniemi, Helena, Derr, Kimberly, de Andrade, Mariza, McCarty, Catherine A., Kitchner, Terrie E., Ragon, Brittany K., Stallings, Sarah C., Papa, Gabriella, Bochenek, Joseph, Smith, Maureen E., Aufox, Sharon A., Pacheco, Jennifer A., Patel, Vaibhav, Friesema, Elisha M., Erwin, Angelika Ludtke, Gottesman, Omri, Gerhard, Glenn S., Ritchie, Marylyn, Motulsky, Arno G., Kullo, Iftikhar J., Larson, Eric B., Tromp, Gerard, Brilliant, Murray H., Bottinger, Erwin, Denny, Joshua C., Roden, Dan M., Williams, Marc S., Jarvik, Gail P.
Publicado 2015

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) St...

por Fernández-Rhodes, Lindsay, Malinowski, Jennifer R., Wang, Yujie, Tao, Ran, Pankratz, Nathan, Jeff, Janina M., Yoneyama, Sachiko, Carty, Cara L., Setiawan, V. Wendy, Le Marchand, Loic, Haiman, Christopher, Corbett, Steven, Demerath, Ellen, Heiss, Gerardo, Gross, Myron, Buzkova, Petra, Crawford, Dana C., Hunt, Steven C., Rao, D. C., Schwander, Karen, Chakravarti, Aravinda, Gottesman, Omri, Abul-Husn, Noura S., Bottinger, Erwin P., Loos, Ruth J. F., Raffel, Leslie J., Yao, Jie, Guo, Xiuqing, Bielinski, Suzette J., Rotter, Jerome I., Vaidya, Dhananjay, Chen, Yii-Der Ida, Castañeda, Sheila F., Daviglus, Martha, Kaplan, Robert, Talavera, Gregory A., Ryckman, Kelli K., Peters, Ulrike, Ambite, Jose Luis, Buyske, Steven, Hindorff, Lucia, Kooperberg, Charles, Matise, Tara, Franceschini, Nora, North, Kari E.
Publicado 2018

Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multi-Center Pilot for Pre-Emptive Pharmacogenomics in Electronic Health Record Systems

por Rasmussen-Torvik, Laura J., Stallings, Sarah C., Gordon, Adam S., Almoguera, Berta, Basford, Melissa A., Bielinski, Suzette J., Brautbar, Ariel, Brilliant, Murray, Carrell, David S., Connolly, John, Crosslin, David R., Doheny, Kimberly F., Gallego, Carlos J., Gottesman, Omri, Kim, Daniel Seung, Leppig, Kathleen A., Li, Rongling, Lin, Simon, Manzi, Shannon, Mejia, Ana R., Pacheco, Jennifer A., Pan, Vivian, Pathak, Jyotishman, Perry, Cassandra L., Peterson, Josh F., Prows, Cynthia A., Ralston, James, Rasmussen, Luke V., Ritchie, Marylyn D., Sadhasivam, Senthilkumar, Scott, Stuart A., Smith, Maureen, Vega, Aida, Vinks, Alexander A., Volpi, Simona, Wolf, Wendy A., Bottinger, Erwin, Chisholm, Rex L., Chute, Christopher G., Haines, Jonathan L., Harley, John B., Keating, Brendan, Holm, Ingrid A., Kullo, Iftikhar J., Jarvik, Gail P., Larson, Eric B., Manolio, Teri, McCarty, Catherine A., Nickerson, Deborah A., Scherer, Steven E., Williams, Marc S., Roden, Dan M., Denny, Joshua C.
Publicado 2014

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

por Ng, Maggie C. Y., Shriner, Daniel, Chen, Brian H., Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J., Yanek, Lisa R., Nalls, Michael A., Comeau, Mary E., Rasmussen-Torvik, Laura J., Jensen, Richard A., Evans, Daniel S., Sun, Yan V., An, Ping, Patel, Sanjay R., Lu, Yingchang, Long, Jirong, Armstrong, Loren L., Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M., Palmer, Nicholette D., Mudgal, Poorva, Langefeld, Carl D., Keene, Keith L., Freedman, Barry I., Mychaleckyj, Josyf C., Nayak, Uma, Raffel, Leslie J., Goodarzi, Mark O., Chen, Y-D Ida, Taylor, Herman A., Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S., Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A., Vaidya, Dhananjay, Singleton, Andrew B., Zonderman, Alan B., Igo, Robert P., Sedor, John R., Kabagambe, Edmond K., Siscovick, David S., McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F., Kraja, Aldi, Province, Michael A., Bottinger, Erwin P., Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J., Lowe, William L., Pacheco, Jennifer A., Crawford, Dana C., Grundberg, Elin, Rich, Stephen S., Hayes, M. Geoffrey, Shu, Xiao-Ou, Loos, Ruth J. F., Borecki, Ingrid B., Peyser, Patricia A., Cummings, Steven R., Psaty, Bruce M., Fornage, Myriam, Iyengar, Sudha K., Evans, Michele K., Becker, Diane M., Kao, W. H. Linda, Wilson, James G., Rotter, Jerome I., Sale, Michèle M., Liu, Simin, Rotimi, Charles N., Bowden, Donald W.
Publicado 2014

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

por Gusarova, Viktoria, O’Dushlaine, Colm, Teslovich, Tanya M., Benotti, Peter N., Mirshahi, Tooraj, Gottesman, Omri, Van Hout, Cristopher V., Murray, Michael F., Mahajan, Anubha, Nielsen, Jonas B., Fritsche, Lars, Wulff, Anders Berg, Gudbjartsson, Daniel F., Sjögren, Marketa, Emdin, Connor A., Scott, Robert A., Lee, Wen-Jane, Small, Aeron, Kwee, Lydia C., Dwivedi, Om Prakash, Prasad, Rashmi B., Bruse, Shannon, Lopez, Alexander E., Penn, John, Marcketta, Anthony, Leader, Joseph B., Still, Christopher D., Kirchner, H. Lester, Mirshahi, Uyenlinh L., Wardeh, Amr H., Hartle, Cassandra M., Habegger, Lukas, Fetterolf, Samantha N., Tusie-Luna, Teresa, Morris, Andrew P., Holm, Hilma, Steinthorsdottir, Valgerdur, Sulem, Patrick, Thorsteinsdottir, Unnur, Rotter, Jerome I., Chuang, Lee-Ming, Damrauer, Scott, Birtwell, David, Brummett, Chad M., Khera, Amit V., Natarajan, Pradeep, Orho-Melander, Marju, Flannick, Jason, Lotta, Luca A., Willer, Cristen J., Holmen, Oddgeir L., Ritchie, Marylyn D., Ledbetter, David H., Murphy, Andrew J., Borecki, Ingrid B., Reid, Jeffrey G., Overton, John D., Hansson, Ola, Groop, Leif, Shah, Svati H., Kraus, William E., Rader, Daniel J., Chen, Yii-Der I., Hveem, Kristian, Wareham, Nicholas J., Kathiresan, Sekar, Melander, Olle, Stefansson, Kari, Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Abecasis, Goncalo R., Altshuler, David, Florez, Jose C., Boehnke, Michael, McCarthy, Mark I., Yancopoulos, George D., Carey, David J., Shuldiner, Alan R., Baras, Aris, Dewey, Frederick E., Gromada, Jesper
Publicado 2018

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

por Wain, Louise V, Shrine, Nick, Soler Artigas, María, Erzurumluoglu, A Mesut, Noyvert, Boris, Bossini-Castillo, Lara, Obeidat, Ma’en, Henry, Amanda P, Portelli, Michael A, Hall, Robert J, Billington, Charlotte K, Rimington, Tracy L, Fenech, Anthony G, John, Catherine, Blake, Tineka, Jackson, Victoria E, Allen, Richard J, Prins, Bram P, Campbell, Archie, Porteous, David J, Jarvelin, Marjo-Riitta, Wielscher, Matthias, James, Alan L, Hui, Jennie, Wareham, Nicholas J, Zhao, Jing Hua, Wilson, James F, Joshi, Peter K, Stubbe, Beate, Rawal, Rajesh, Schulz, Holger, Imboden, Medea, Probst-Hensch, Nicole M, Karrasch, Stefan, Gieger, Christian, Deary, Ian J, Harris, Sarah E, Marten, Jonathan, Rudan, Igor, Enroth, Stefan, Gyllensten, Ulf, Kerr, Shona M, Polasek, Ozren, Kähönen, Mika, Surakka, Ida, Vitart, Veronique, Hayward, Caroline, Lehtimäki, Terho, Raitakari, Olli T, Evans, David M, Henderson, A John, Pennell, Craig E, Wang, Carol A, Sly, Peter D, Wan, Emily S, Busch, Robert, Hobbs, Brian D, Litonjua, Augusto A, Sparrow, David W, Gulsvik, Amund, Bakke, Per S, Crapo, James D, Beaty, Terri H, Hansel, Nadia N, Mathias, Rasika A, Ruczinski, Ingo, Barnes, Kathleen C, Bossé, Yohan, Joubert, Philippe, van den Berge, Maarten, Brandsma, Corry-Anke, Paré, Peter D, Sin, Don D, Nickle, David C, Hao, Ke, Gottesman, Omri, Dewey, Frederick E, Bruse, Shannon E, Carey, David J, Kirchner, H Lester, Jonsson, Stefan, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Gislason, Thorarinn, Stefansson, Kari, Schurmann, Claudia, Nadkarni, Girish, Bottinger, Erwin P, Loos, Ruth JF, Walters, Robin G, Chen, Zhengming, Millwood, Iona Y, Vaucher, Julien, Kurmi, Om P, Li, Liming, Hansell, Anna L, Brightling, Chris, Zeggini, Eleftheria, Cho, Michael H, Silverman, Edwin K, Sayers, Ian, Trynka, Gosia, Morris, Andrew P, Strachan, David P, Hall, Ian P, Tobin, Martin D
Publicado 2017

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

por Gorski, Mathias, van der Most, Peter J., Teumer, Alexander, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Nolte, Ilja M., Cocca, Massimiliano, Taliun, Daniel, Gomez, Felicia, Li, Yong, Tayo, Bamidele, Tin, Adrienne, Feitosa, Mary F., Aspelund, Thor, Attia, John, Biffar, Reiner, Bochud, Murielle, Boerwinkle, Eric, Borecki, Ingrid, Bottinger, Erwin P., Chen, Ming-Huei, Chouraki, Vincent, Ciullo, Marina, Coresh, Josef, Cornelis, Marilyn C., Curhan, Gary C., d’Adamo, Adamo Pio, Dehghan, Abbas, Dengler, Laura, Ding, Jingzhong, Eiriksdottir, Gudny, Endlich, Karlhans, Enroth, Stefan, Esko, Tõnu, Franco, Oscar H., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hancock, Stephen J., Harris, Tamara B., Helmer, Catherine, Höllerer, Simon, Hofer, Edith, Hofman, Albert, Holliday, Elizabeth G., Homuth, Georg, Hu, Frank B., Huth, Cornelia, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Imboden, Medea, Johansson, Åsa, Kähönen, Mika, König, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kumar, Ashish, Kutalik, Zoltan, Lambert, Jean-Charles, Launer, Lenore J., Lehtimäki, Terho, de Borst, Martin, Navis, Gerjan, Swertz, Morris, Liu, Yongmei, Lohman, Kurt, Loos, Ruth J. F., Lu, Yingchang, Lyytikäinen, Leo-Pekka, McEvoy, Mark A., Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Metzger, Marie, Mihailov, Evelin, Mitchell, Paul, Nauck, Matthias, Oldehinkel, Albertine J., Olden, Matthias, WJH Penninx, Brenda, Pistis, Giorgio, Pramstaller, Peter P., Probst-Hensch, Nicole, Raitakari, Olli T., Rettig, Rainer, Ridker, Paul M., Rivadeneira, Fernando, Robino, Antonietta, Rosas, Sylvia E., Ruderfer, Douglas, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia, Schmidt, Helena, Schmidt, Reinhold, Scott, Rodney J., Sedaghat, Sanaz, Smith, Albert V., Sorice, Rossella, Stengel, Benedicte, Stracke, Sylvia, Strauch, Konstantin, Toniolo, Daniela, Uitterlinden, Andre G., Ulivi, Sheila, Viikari, Jorma S., Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Vuckovic, Dragana, Waldenberger, Melanie, Jin Wang, Jie, Yang, Qiong, Chasman, Daniel I., Tromp, Gerard, Snieder, Harold, Heid, Iris M., Fox, Caroline S., Köttgen, Anna, Pattaro, Cristian, Böger, Carsten A., Fuchsberger, Christian
Publicado 2017