Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

por Ajuyah, Pamela, Mayoh, Chelsea, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Chambers, Hazel, Valdes-Mora, Fatima, Senapati, Akanksha, Gifford, Andrew J., D’Arcy, Colleen, Hansford, Jordan R., Manoharan, Neevika, Nicholls, Wayne, Williams, Molly M., Wood, Paul J., Cowley, Mark J., Tyrrell, Vanessa, Haber, Michelle, Ekert, Paul G., Ziegler, David S., Khuong-Quang, Dong-Anh
Publicado 2023

DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) I...

por Ehteda, Anahid, Franshaw, Laura, Liu, Jie, Joshi, Swapna, Simon, Sandy, Pang, Chi Nam Ignatius, Giorgi, Federico, Pandher, Ruby, Ung, Caitlin, Tolhurst, Ornella, Mayoh, Chelsea, Khan, Aaminah, Hayden, Elisha, Gopalakrishnan, Anjana, Trebilcock, Peter, Upton, Dannielle, Lehmann, Rebecca, George, Sandra, Vittorio, Orazio, Tsoli, Maria, Gurova, Katerina, Gudkov, Andrei Gudkov, Norris, Murray D, Haber, Michelle, Ziegler, David S
Publicado 2020

HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG

por Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M, Liu, Jie, Hayden, Elisha, Rouaen, Jourdin, Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Kankean, Anne, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei, Norris, Murray D, Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S
Publicado 2021

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

por Henderson, Michelle J., Haber, Michelle, Porro, Antonio, Munoz, Marcia A., Iraci, Nunzio, Xue, Chengyuan, Murray, Jayne, Flemming, Claudia L., Smith, Janice, Fletcher, Jamie I., Gherardi, Samuele, Kwek, Chin-Kiat, Russell, Amanda J., Valli, Emanuele, London, Wendy B., Buxton, Allen B., Ashton, Lesley J., Sartorelli, Alan C., Cohn, Susan L., Schwab, Manfred, Marshall, Glenn M., Perini, Giovanni, Norris, Murray D.
Publicado 2011

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

por Decock, Anneleen, Ongenaert, Maté, Cannoodt, Robrecht, Verniers, Kimberly, De Wilde, Bram, Laureys, Geneviève, Van Roy, Nadine, Berbegall, Ana P., Bienertova-Vasku, Julie, Bown, Nick, Clément, Nathalie, Combaret, Valérie, Haber, Michelle, Hoyoux, Claire, Murray, Jayne, Noguera, Rosa, Pierron, Gaelle, Schleiermacher, Gudrun, Schulte, Johannes H., Stallings, Ray L., Tweddle, Deborah A., De Preter, Katleen, Speleman, Frank, Vandesompele, Jo
Publicado 2015

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

por Tsoli, Maria, Wadham, Carol, Pinese, Mark, Failes, Tim, Joshi, Swapna, Mould, Emily, Yin, Julia X., Gayevskiy, Velimir, Kumar, Amit, Kaplan, Warren, Ekert, Paul G., Saletta, Federica, Franshaw, Laura, Liu, Jie, Gifford, Andrew, Weber, Martin A., Rodriguez, Michael, Cohn, Richard J., Arndt, Greg, Tyrrell, Vanessa, Haber, Michelle, Trahair, Toby, Marshall, Glenn M., McDonald, Kerrie, Cowley, Mark J., Ziegler, David S.
Publicado 2018

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

por Xiao, Lin, Karsa, Mawar, Ronca, Emma, Bongers, Angelika, Kosciolek, Angelika, El-Ayoubi, Ali, Revalde, Jezrael L., Seneviratne, Janith A., Cheung, Belamy B., Cheung, Laurence C., Kotecha, Rishi S., Newbold, Andrea, Bjelosevic, Stefan, Arndt, Greg M., Lock, Richard B., Johnstone, Ricky W., Gudkov, Andrei V., Gurova, Katerina V., Haber, Michelle, Norris, Murray D., Henderson, Michelle J., Somers, Klaartje
Publicado 2022

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs

por Liu, Pei Y., Sokolowski, Nicholas, Guo, Su T., Siddiqi, Faraz, Atmadibrata, Bernard, Telfer, Thomas J., Sun, Yuting, Zhang, Lihong, Yu, Denise, Mccarroll, Joshua, Liu, Bing, Yang, Rui H., Guo, Xiang Y., Tee, Andrew E., Itoh, Ken, Wang, Jenny, Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Cheung, Belamy B., Byrne, Jennifer A., Ziegler, David S., Marshall, Glenn M., Dinger, Marcel E., Codd, Rachel, Zhang, Xu D., Liu, Tao
Publicado 2016

DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM

por Khuong-Quang, Dong-Anh, Nagabushan, Sumanth, Manoharan, Neevika, Arndt, Greg, Barahona, Paulette, Cowley, Mark J, Ekert, Paul G, Failes, Tim, Bolanos, Noemi Fuentes, Gauthier, Maely, Gifford, Andrew J, Haber, Michelle, Kumar, Amit, Lock, Richard B, Marshall, Glenn M, Mayoh, Chelsea, Mould, Emily, Norris, Murray D, Gopalakrishnan, Anjana, Omer, Natacha, Trebilcock, Peter, Trahair, Toby N, Tsoli, Maria, Tucker, Katherine, Wong, Marie, Tyrrell, Vanessa, Lau, Loretta, S, Ziegler, David
Publicado 2020

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

por Cheung, Belamy B., Kleynhans, Ane, Mittra, Rituparna, Kim, Patrick Y., Holien, Jessica K., Nagy, Zsuzsanna, Ciampa, Olivia C., Seneviratne, Janith A., Mayoh, Chelsea, Raipuria, Mukesh, Gadde, Satyanarayana, Massudi, Hassina, Wong, Iris Poh Ling, Tan, Owen, Gong, Andrew, Suryano, Aldwin, Diakiw, Sonya M., Liu, Bing, Arndt, Greg M., Liu, Tao, Kumar, Naresh, Sangfelt, Olle, Zhu, Shizhen, Norris, Murray D., Haber, Michelle, Carter, Daniel R., Parker, Michael W., Marshall, Glenn M.
Publicado 2021

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

por Wong, Matthew, Sun, Yuting, Xi, Zhichao, Milazzo, Giorgio, Poulos, Rebecca C., Bartenhagen, Christoph, Bell, Jessica L., Mayoh, Chelsea, Ho, Nicholas, Tee, Andrew E., Chen, Xiaoqiong, Li, Yang, Ciaccio, Roberto, Liu, Pei Y., Jiang, Chen C., Lan, Qing, Jayatilleke, Nisitha, Cheung, Belamy B., Haber, Michelle, Norris, Murray D., Zhang, Xu D., Marshall, Glenn M., Wang, Jenny Y., Hüttelmaier, Stefan, Fischer, Matthias, Wong, Jason W. H., Xu, Hongxi, Perini, Giovanni, Dong, Qihan, George, Rani E., Liu, Tao
Publicado 2019

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

por Mayoh, Chelsea, Mao, Jie, Xie, Jinhan, Tax, Gabor, Chow, Shu-Oi, Cadiz, Roxanne, Pazaky, Karina, Barahona, Paulette, Ajuyah, Pamela, Trebilcock, Peter, Malquori, Angela, Gunther, Kate, Avila, Anica, Yun, Doo Young, Alfred, Stephanie, Gopalakrishnan, Anjana, Kamili, Alvin, Wong, Marie, Cowley, Mark J., Jessop, Sophie, Lau, Loretta M.S., Trahair, Toby N., Ziegler, David S., Fletcher, Jamie I., Gifford, Andrew J., Tsoli, Maria, Marshall, Glenn M., Haber, Michelle, Tyrrell, Vanessa, Failes, Timothy W., Arndt, Greg M., Lock, Richard B., Ekert, Paul G., Dolman, M. Emmy M.
Publicado 2023

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

por Liu, Pei Y., Tee, Andrew E., Milazzo, Giorgio, Hannan, Katherine M., Maag, Jesper, Mondal, Sujanna, Atmadibrata, Bernard, Bartonicek, Nenad, Peng, Hui, Ho, Nicholas, Mayoh, Chelsea, Ciaccio, Roberto, Sun, Yuting, Henderson, Michelle J., Gao, Jixuan, Everaert, Celine, Hulme, Amy J., Wong, Matthew, Lan, Qing, Cheung, Belamy B., Shi, Leming, Wang, Jenny Y., Simon, Thorsten, Fischer, Matthias, Zhang, Xu D., Marshall, Glenn M., Norris, Murray D., Haber, Michelle, Vandesompele, Jo, Li, Jinyan, Mestdagh, Pieter, Hannan, Ross D., Dinger, Marcel E., Perini, Giovanni, Liu, Tao
Publicado 2019

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

por Hastings, Jordan F., Latham, Sharissa L., Kamili, Alvin, Wheatley, Madeleine S., Han, Jeremy Z. R., Wong-Erasmus, Marie, Phimmachanh, Monica, Nobis, Max, Pantarelli, Chiara, Cadell, Antonia L., O’Donnell, Yolande E. I., Leong, King Ho, Lynn, Sophie, Geng, Fan-Suo, Cui, Lujing, Yan, Sabrina, Achinger-Kawecka, Joanna, Stirzaker, Clare, Norris, Murray D., Haber, Michelle, Trahair, Toby N., Speleman, Frank, De Preter, Katleen, Cowley, Mark J., Bogdanovic, Ozren, Timpson, Paul, Cox, Thomas R., Kolch, Walter, Fletcher, Jamie I., Fey, Dirk, Croucher, David R.
Publicado 2023

A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

por Gamble, Laura D., Purgato, Stefania, Henderson, Michelle J., Di Giacomo, Simone, Russell, Amanda J., Pigini, Paolo, Murray, Jayne, Valli, Emanuele, Milazzo, Giorgio, Giorgi, Federico M., Cowley, Mark, Ashton, Lesley J., Bhalshankar, Jaydutt, Schleiermacher, Gudrun, Rihani, Ali, Van Maerken, Tom, Vandesompele, Jo, Speleman, Frank, Versteeg, Rogier, Koster, Jan, Eggert, Angelika, Noguera, Rosa, Stallings, Raymond L., Tonini, Gian Paolo, Fong, Kwun, Vaksman, Zalman, Diskin, Sharon J., Maris, John M., London, Wendy B., Marshall, Glenn M., Ziegler, David S., Hogarty, Michael D., Perini, Giovanni, Norris, Murray D., Haber, Michelle
Publicado 2021

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

por Somers, Klaartje, Wen, Victoria W., Middlemiss, Shiloh M. C., Osborne, Brenna, Forgham, Helen, Jung, MoonSun, Karsa, Mawar, Clifton, Molly, Bongers, Angelika, Gao, Jixuan, Mayoh, Chelsea, Raoufi-Rad, Newsha, Kusnadi, Eric P., Hannan, Kate M., Scott, David A., Kwek, Alan, Liu, Bing, Flemming, Claudia, Chudakova, Daria A., Pandher, Ruby, Failes, Tim W., Lim, James, Angeli, Andrea, Osterman, Andrei L., Imamura, Toshihiko, Kees, Ursula R., Supuran, Claudiu T., Pearson, Richard B., Hannan, Ross D., Davis, Thomas P., McCarroll, Joshua, Kavallaris, Maria, Turner, Nigel, Gudkov, Andrei V., Haber, Michelle, Norris, Murray D., Henderson, Michelle J.
Publicado 2019

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

por Grohmann, Christoph, Walker, Francesca, Devlin, Mark, Luo, Meng-Xiao, Chüeh, Anderly C., Doherty, Judy, Vaillant, François, Ho, Gwo-Yaw, Wakefield, Matthew J., Weeden, Clare E., Kamili, Alvin, Murray, Jayne, Po’uha, Sela T., Weinstock, Janet, Kane, Serena R., Faux, Maree C., Broekhuizen, Esmee, Zheng, Ye, Shield-Artin, Kristy, Kershaw, Nadia J., Tan, Chin Wee, Witchard, Helen M., Ebert, Gregor, Charman, Susan A., Street, Ian, Kavallaris, Maria, Haber, Michelle, Fletcher, Jamie I., Asselin-Labat, Marie-Liesse, Scott, Clare L., Visvader, Jane E., Lindeman, Geoffrey J., Watson, Keith G., Burgess, Antony W., Lessene, Guillaume
Publicado 2021

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

por Mayoh, Chelsea, Gifford, Andrew J., Terry, Rachael, Lau, Loretta M. S., Wong, Marie, Rao, Padmashree, Shai-Hee, Tyler, Saletta, Federica, Khuong-Quang, Dong-Anh, Qin, Vicky, Mateos, Marion K., Meyran, Deborah, Miller, Katherine E., Yuksel, Aysen, Mould, Emily V. A., Bowen-James, Rachel, Govender, Dinisha, Senapati, Akanksha, Zhukova, Nataliya, Omer, Natacha, Dholaria, Hetal, Alvaro, Frank, Tapp, Heather, Diamond, Yonatan, Pozza, Luciano Dalla, Moore, Andrew S., Nicholls, Wayne, Gottardo, Nicholas G., McCowage, Geoffrey, Hansford, Jordan R., Khaw, Seong-Lin, Wood, Paul J., Catchpoole, Daniel, Cottrell, Catherine E., Mardis, Elaine R., Marshall, Glenn M., Tyrrell, Vanessa, Haber, Michelle, Ziegler, David S., Vittorio, Orazio, Trapani, Joseph A., Cowley, Mark J., Neeson, Paul J., Ekert, Paul G.
Publicado 2023

In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer

por Lau, Loretta M S, Mayoh, Chelsea, Xie, Jinhan, Barahona, Paulette, MacKenzie, Karen L, Wong, Marie, Kamili, Alvin, Tsoli, Maria, Failes, Tim W, Kumar, Amit, Mould, Emily V A, Gifford, Andrew, Chow, Shu‐Oi, Pinese, Mark, Fletcher, Jamie I, Arndt, Greg M, Khuong‐Quang, Dong‐Anh, Wadham, Carol, Batey, Daniel, Eden, Georgina, Trebilcock, Peter, Joshi, Swapna, Alfred, Stephanie, Gopalakrishnan, Anjana, Khan, Aaminah, Grebert Wade, Dylan, Strong, Patrick A, Manouvrier, Elodie, Morgan, Lisa T, Span, Miriam, Lim, Jin Yi, Cadiz, Roxanne, Ung, Caitlin, Thomas, David M, Tucker, Katherine M, Warby, Meera, McCowage, Geoffrey B, Dalla‐Pozza, Luciano, Byrne, Jennifer A, Saletta, Federica, Fellowes, Andrew, Fox, Stephen B, Norris, Murray D, Tyrrell, Vanessa, Trahair, Toby N, Lock, Richard B, Cowley, Mark J, Ekert, Paul G, Haber, Michelle, Ziegler, David S, Marshall, Glenn M
Publicado 2021

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

por French, Juliet D., Johnatty, Sharon E., Lu, Yi, Beesley, Jonathan, Gao, Bo, Kalimutho, Murugan, Henderson, Michelle J., Russell, Amanda J., Kar, Siddhartha, Chen, Xiaoqing, Hillman, Kristine M., Kaufmann, Susanne, Sivakumaran, Haran, O'Reilly, Martin, Wang, Chen, Korbie, Darren J., Lambrechts, Diether, Despierre, Evelyn, Van Nieuwenhuysen, Els, Lambrechts, Sandrina, Vergote, Ignace, Karlan, Beth, Lester, Jenny, Orsulic, Sandra, Walsh, Christine, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander, Matsuo, Keitaro, Hosono, Satoyo, Pisterer, Jacobus, Hillemanns, Peter, Nakanishi, Toru, Yatabe, Yasushi, Goodman, Marc T., Lurie, Galina, Matsuno, Rayna K., Thompson, Pamela J., Pejovic, Tanja, Bean, Yukie, Heitz, Florian, Harter, Philipp, du Bois, Andreas, Schwaab, Ira, Hogdall, Estrid, Kjaer, Susanne K., Jensen, Allan, Hogdall, Claus, Lundvall, Lene, Engelholm, Svend Aage, Brown, Bob, Flanagan, James M., Metcalf, Michelle D., Siddiqui, Nadeem, Sellers, Thomas, Fridley, Brooke, Cunningham, Julie, Schildkraut, Joellen M., Iversen, Ed, Weber, Rachel Palmieri, Brennan, Donal, Berchuck, Andrew, Pharoah, Paul, Harnett, Paul, Norris, Murray D., Haber, Michelle, Goode, Ellen L., Lee, Jason S., Khanna, Kum Kum, Meyer, Kerstin B., Chenevix-Trench, Georgia, deFazio, Anna, Edwards, Stacey L., MacGregor, Stuart
Publicado 2016