Genetic identification of brain cell types underlying schizophrenia

por Skene, Nathan G, Bryois, Julien, Bakken, Trygve E, Breen, Gerome, Crowley, James J, Gaspar, Héléna A, Giusti-Rodriguez, Paola, Hodge, Rebecca D, Miller, Jeremy A, Muñoz-Manchado, Ana B, O’Donovan, Michael C, Owen, Michael J, Pardiñas, Antonio F, Ryge, Jesper, Walters, James T R, Linnarsson, Sten, Lein, Ed S, Sullivan, Patrick F, Hjerling-Leffler, Jens
Publicado 2018

Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types

por Driessens, Stan L. W., Galakhova, Anna A., Heyer, Djai B., Pieterse, Isabel J., Wilbers, René, Mertens, Eline J., Waleboer, Femke, Heistek, Tim S., Coenen, Loet, Meijer, Julia R., Idema, Sander, de Witt Hamer, Philip C., Noske, David P., de Kock, Christiaan P. J., Lee, Brian R., Smith, Kimberly, Ting, Jonathan T., Lein, Ed S., Mansvelder, Huibert D., Goriounova, Natalia A.
Publicado 2023

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

por Bakken, Trygve E., Hodge, Rebecca D., Miller, Jeremy A., Yao, Zizhen, Nguyen, Thuc Nghi, Aevermann, Brian, Barkan, Eliza, Bertagnolli, Darren, Casper, Tamara, Dee, Nick, Garren, Emma, Goldy, Jeff, Graybuck, Lucas T., Kroll, Matthew, Lasken, Roger S., Lathia, Kanan, Parry, Sheana, Rimorin, Christine, Scheuermann, Richard H., Schork, Nicholas J., Shehata, Soraya I., Tieu, Michael, Phillips, John W., Bernard, Amy, Smith, Kimberly A., Zeng, Hongkui, Lein, Ed S., Tasic, Bosiljka
Publicado 2018

Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization

por Lee, Brian R, Budzillo, Agata, Hadley, Kristen, Miller, Jeremy A, Jarsky, Tim, Baker, Katherine, Hill, DiJon, Kim, Lisa, Mann, Rusty, Ng, Lindsay, Oldre, Aaron, Rajanbabu, Ram, Trinh, Jessica, Vargas, Sara, Braun, Thomas, Dalley, Rachel A, Gouwens, Nathan W, Kalmbach, Brian E, Kim, Tae Kyung, Smith, Kimberly A, Soler-Llavina, Gilberto, Sorensen, Staci, Tasic, Bosiljka, Ting, Jonathan T, Lein, Ed, Zeng, Hongkui, Murphy, Gabe J, Berg, Jim
Publicado 2021

Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

por Hunt, Sarah, Leibner, Yoni, Mertens, Eline J, Barros-Zulaica, Natalí, Kanari, Lida, Heistek, Tim S, Karnani, Mahesh M, Aardse, Romy, Wilbers, René, Heyer, Djai B, Goriounova, Natalia A, Verhoog, Matthijs B, Testa-Silva, Guilherme, Obermayer, Joshua, Versluis, Tamara, Benavides-Piccione, Ruth, de Witt-Hamer, Philip, Idema, Sander, Noske, David P, Baayen, Johannes C, Lein, Ed S, DeFelipe, Javier, Markram, Henry, Mansvelder, Huibert D, Schürmann, Felix, Segev, Idan, de Kock, Christiaan P J
Publicado 2022

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

por Chen, Xinhong, Wolfe, Damien A., Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F., Sullivan, Erin, Huang, Sheng-Fu, Kumar, Sripriya Ravindra, Arokiaraj, Cynthia M., Plattner, Viktor, Campos, Lillian J., Mich, John, Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan, Lein, Ed S, Akrami, Athena, Miller, Cory, Levi, Boaz P., Keller, Annika, Ting, Jonathan T., Fox, Andrew S., Eroglu, Cagla, Gradinaru, Viviana
Publicado 2023

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

por Chen, Xinhong, Wolfe, Damien A., Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F., Sullivan, Erin E., Huang, Sheng-Fu, Ravindra Kumar, Sripriya, Arokiaraj, Cynthia M., Plattner, Viktor M., Campos, Lillian J., Mich, John K., Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan B., Lein, Ed S., Akrami, Athena, Miller, Cory, Levi, Boaz P., Keller, Annika, Ting, Jonathan T., Fox, Andrew S., Eroglu, Cagla, Gradinaru, Viviana
Publicado 2023

Canonical Genetic Signatures of the Adult Human Brain

por Hawrylycz, Michael, Miller, Jeremy A., Menon, Vilas, Feng, David, Dolbeare, Tim, Guillozet-Bongaarts, Angela L., Jegga, Anil G., Aronow, Bruce J., Lee, Chang-Kyu, Bernard, Amy, Glasser, Matthew F., Dierker, Donna L., Menche, Jörge, Szafer, Aaron, Collman, Forrest, Grange, Pascal, Berman, Kenneth A., Mihalas, Stefan, Yao, Zizhen, Stewart, Lance, Barabási, Albert-László, Schulkin, Jay, Phillips, John, Ng, Lydia, Dang, Chinh, Haynor, David R., Jones, Allan, Van Essen, David C., Koch, Christof, Lein, Ed
Publicado 2015

Biallelic Mutations In Human DCC Cause Developmental Split Brain Syndrome

por Jamuar, Saumya S., Schmitz-Abe, Klaus, D’Gama, Alissa M., Drottar, Marie, Chan, Wai-Man, Peeva, Maya, Servattalab, Sarah, Lam, Anh-Thu N., Delgado, Mauricio R., Clegg, Nancy J., Al Zayed, Zayed, Dogar, Mohammad Asif, Alorainy, Ibrahim A., Jamea, Abdullah Abu, Abu-Amero, Khaled, Griebel, May, Ward, Wendy, Lein, Ed S., Markianos, Kyriacos, Barkovich, A. James, Robson, Caroline D., Grant, P. Ellen, Bosley, Thomas M., Engle, Elizabeth C., Walsh, Christopher A., Yu, Timothy W.
Publicado 2017

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

por Hodge, Rebecca D., Miller, Jeremy A., Novotny, Mark, Kalmbach, Brian E., Ting, Jonathan T., Bakken, Trygve E., Aevermann, Brian D., Barkan, Eliza R., Berkowitz-Cerasano, Madeline L., Cobbs, Charles, Diez-Fuertes, Francisco, Ding, Song-Lin, McCorrison, Jamison, Schork, Nicholas J., Shehata, Soraya I., Smith, Kimberly A., Sunkin, Susan M., Tran, Danny N., Venepally, Pratap, Yanny, Anna Marie, Steemers, Frank J., Phillips, John W., Bernard, Amy, Koch, Christof, Lasken, Roger S., Scheuermann, Richard H., Lein, Ed S.
Publicado 2020

Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

por Bakken, Trygve E, van Velthoven, Cindy TJ, Menon, Vilas, Hodge, Rebecca D, Yao, Zizhen, Nguyen, Thuc Nghi, Graybuck, Lucas T, Horwitz, Gregory D, Bertagnolli, Darren, Goldy, Jeff, Yanny, Anna Marie, Garren, Emma, Parry, Sheana, Casper, Tamara, Shehata, Soraya I, Barkan, Eliza R, Szafer, Aaron, Levi, Boaz P, Dee, Nick, Smith, Kimberly A, Sunkin, Susan M, Bernard, Amy, Phillips, John, Hawrylycz, Michael J, Koch, Christof, Murphy, Gabe J, Lein, Ed, Zeng, Hongkui, Tasic, Bosiljka
Publicado 2021

Cellular resolution anatomical and molecular atlases for prenatal human brains

por Ding, Song‐Lin, Royall, Joshua J., Lesnar, Phil, Facer, Benjamin A.C., Smith, Kimberly A., Wei, Yina, Brouner, Kristina, Dalley, Rachel A., Dee, Nick, Dolbeare, Tim A., Ebbert, Amanda, Glass, Ian A., Keller, Nika H., Lee, Felix, Lemon, Tracy A., Nyhus, Julie, Pendergraft, Julie, Reid, Robert, Sarreal, Melaine, Shapovalova, Nadiya V., Szafer, Aaron, Phillips, John W., Sunkin, Susan M., Hohmann, John G., Jones, Allan R., Hawrylycz, Michael J., Hof, Patrick R., Ng, Lydia, Bernard, Amy, Lein, Ed S.
Publicado 2021

Single nucleus multi-omics identifies human cortical cell regulatory genome diversity

por Luo, Chongyuan, Liu, Hanqing, Xie, Fangming, Armand, Ethan J., Siletti, Kimberly, Bakken, Trygve E., Fang, Rongxin, Doyle, Wayne I., Stuart, Tim, Hodge, Rebecca D., Hu, Lijuan, Wang, Bang-An, Zhang, Zhuzhu, Preissl, Sebastian, Lee, Dong-Sung, Zhou, Jingtian, Niu, Sheng-Yong, Castanon, Rosa, Bartlett, Anna, Rivkin, Angeline, Wang, Xinxin, Lucero, Jacinta, Nery, Joseph R., Davis, David A., Mash, Deborah C., Satija, Rahul, Dixon, Jesse R., Linnarsson, Sten, Lein, Ed, Behrens, M. Margarita, Ren, Bing, Mukamel, Eran A., Ecker, Joseph R.
Publicado 2022

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type

por Boldog, Eszter, Bakken, Trygve E., Hodge, Rebecca D., Novotny, Mark, Aevermann, Brian D., Baka, Judith, Bordé, Sándor, Close, Jennie L., Diez-Fuertes, Francisco, Ding, Song-Lin, Faragó, Nóra, Kocsis, Ágnes K., Kovács, Balázs, Maltzer, Zoe, McCorrison, Jamison M., Miller, Jeremy A., Molnár, Gábor, Oláh, Gáspár, Ozsvár, Attila, Rózsa, Márton, Shehata, Soraya I., Smith, Kimberly A., Sunkin, Susan M., Tran, Danny N., Venepally, Pratap, Wall, Abby, Puskás, László G., Barzó, Pál, Steemers, Frank J., Schork, Nicholas J., Scheuermann, Richard H., Lasken, Roger S., Lein, Ed S., Tamás, Gábor
Publicado 2018

Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

por Kim, Mean-Hwan, Radaelli, Cristina, Thomsen, Elliot R, Monet, Deja, Chartrand, Thomas, Jorstad, Nikolas L, Mahoney, Joseph T, Taormina, Michael J, Long, Brian, Baker, Katherine, Bakken, Trygve E, Campagnola, Luke, Casper, Tamara, Clark, Michael, Dee, Nick, D'Orazi, Florence, Gamlin, Clare, Kalmbach, Brian E, Kebede, Sara, Lee, Brian R, Ng, Lindsay, Trinh, Jessica, Cobbs, Charles, Gwinn, Ryder P, Keene, C Dirk, Ko, Andrew L, Ojemann, Jeffrey G, Silbergeld, Daniel L, Sorensen, Staci A, Berg, Jim, Smith, Kimberly A, Nicovich, Philip R, Jarsky, Tim, Zeng, Hongkui, Ting, Jonathan T, Levi, Boaz P, Lein, Ed
Publicado 2023

Comprehensive cellular‐resolution atlas of the adult human brain

por Ding, Song‐Lin, Royall, Joshua J., Sunkin, Susan M., Ng, Lydia, Facer, Benjamin A.C., Lesnar, Phil, Guillozet‐Bongaarts, Angie, McMurray, Bergen, Szafer, Aaron, Dolbeare, Tim A., Stevens, Allison, Tirrell, Lee, Benner, Thomas, Caldejon, Shiella, Dalley, Rachel A., Dee, Nick, Lau, Christopher, Nyhus, Julie, Reding, Melissa, Riley, Zackery L., Sandman, David, Shen, Elaine, van der Kouwe, Andre, Varjabedian, Ani, Write, Michelle, Zollei, Lilla, Dang, Chinh, Knowles, James A., Koch, Christof, Phillips, John W., Sestan, Nenad, Wohnoutka, Paul, Zielke, H. Ronald, Hohmann, John G., Jones, Allan R., Bernard, Amy, Hawrylycz, Michael J., Hof, Patrick R., Fischl, Bruce, Lein, Ed S.
Publicado 2016

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

por Mich, John K., Graybuck, Lucas T., Hess, Erik E., Mahoney, Joseph T., Kojima, Yoshiko, Ding, Yi, Somasundaram, Saroja, Miller, Jeremy A., Kalmbach, Brian E., Radaelli, Cristina, Gore, Bryan B., Weed, Natalie, Omstead, Victoria, Bishaw, Yemeserach, Shapovalova, Nadiya V., Martinez, Refugio A., Fong, Olivia, Yao, Shenqin, Mortrud, Marty, Chong, Peter, Loftus, Luke, Bertagnolli, Darren, Goldy, Jeff, Casper, Tamara, Dee, Nick, Opitz-Araya, Ximena, Cetin, Ali, Smith, Kimberly A., Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew L., Ojemann, Jeffrey G., Keene, C. Dirk, Silbergeld, Daniel L., Sunkin, Susan M., Gradinaru, Viviana, Horwitz, Gregory D., Zeng, Hongkui, Tasic, Bosiljka, Lein, Ed S., Ting, Jonathan T., Levi, Boaz P.
Publicado 2021

Oligodendrocyte precursor cells ingest axons in the mouse neocortex

por Buchanan, JoAnn, Elabbady, Leila, Collman, Forrest, Jorstad, Nikolas L., Bakken, Trygve E., Ott, Carolyn, Glatzer, Jenna, Bleckert, Adam A., Bodor, Agnes L., Brittain, Derrick, Bumbarger, Daniel J., Mahalingam, Gayathri, Seshamani, Sharmishtaa, Schneider-Mizell, Casey, Takeno, Marc M., Torres, Russel, Yin, Wenjing, Hodge, Rebecca D., Castro, Manuel, Dorkenwald, Sven, Ih, Dodam, Jordan, Chris S., Kemnitz, Nico, Lee, Kisuk, Lu, Ran, Macrina, Thomas, Mu, Shang, Popovych, Sergiy, Silversmith, William M., Tartavull, Ignacio, Turner, Nicholas L., Wilson, Alyssa M., Wong, William, Wu, Jingpeng, Zlateski, Aleksandar, Zung, Jonathan, Lippincott-Schwartz, Jennifer, Lein, Ed S., Seung, H. Sebastian, Bergles, Dwight E., Reid, R. Clay, da Costa, Nuno Maçarico
Publicado 2022

The complete genome sequence of a Neandertal from the Altai Mountains

por Prüfer, Kay, Racimo, Fernando, Patterson, Nick, Jay, Flora, Sankararaman, Sriram, Sawyer, Susanna, Heinze, Anja, Renaud, Gabriel, Sudmant, Peter H., de Filippo, Cesare, Li, Heng, Mallick, Swapan, Dannemann, Michael, Fu, Qiaomei, Kircher, Martin, Kuhlwilm, Martin, Lachmann, Michael, Meyer, Matthias, Ongyerth, Matthias, Siebauer, Michael, Theunert, Christoph, Tandon, Arti, Moorjani, Priya, Pickrell, Joseph, Mullikin, James C., Vohr, Samuel H., Green, Richard E., Hellmann, Ines, Johnson, Philip L. F., Blanche, Hélène, Cann, Howard, Kitzman, Jacob O., Shendure, Jay, Eichler, Evan E., Lein, Ed S., Bakken, Trygve E., Golovanova, Liubov V., Doronichev, Vladimir B., Shunkov, Michael V., Derevianko, Anatoli P., Viola, Bence, Slatkin, Montgomery, Reich, David, Kelso, Janet, Pääbo, Svante
Publicado 2013

HGG-06. EARLY GABAERGIC NEURONAL LINEAGE DEFINES DEPENDENCIES IN HISTONE H3 G34R/V GLIOMA

por Liu, Ilon, Bjerke, Lynn, Cruzeiro, Gustavo Alencastro Veiga, Rogers, Rebecca F, Grabovska, Yura, Panditharatna, Eshini, Mackay, Alan, Barron, Tara, Shaw, McKenzie, Hoffman, Samantha E, Hack, Olivia A, Quezada, Michael A, Dempster, Joshua, Temelso, Sara, Englinger, Bernhard, Molinari, Valeria, Mire, Hafsa M, Jiang, Li, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Rota, Christopher, Ricken, Gerda, Alexandrescu, Sanda, Braun, Emelie, Danan-Gotthold, Miri, Hu, Lijuan, Siletti, Kimberly, Sundstroem, Erik, Hodge, Rebecca, Lein, Ed, Agnihotri, Sameer, Eisenstat, David D, Carceller, Fernando, Stapleton, Simon, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina A, Waanders, Angela J, Carcaboso, Angel Montero, Vinci, Maria, Hargrave, Darren, Haberler, Christine, Gojo, Johannes, Slavc, Irene, Linnarsson, Sten, Monje, Michelle, Jones, Chris, Filbin, Mariella G
Publicado 2021