Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity

por Gonçalves, Ana Cláudia, Towers, Emily R., Haq, Naila, Porco, John A., Pelletier, Jerry, Dawson, Sally J., Gale, Jonathan E.
Publicado 2019

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

por Liu, Shufeng, Wang, Wenyu, Brown, Lauren E., Qiu, Chao, Lajkiewicz, Neil, Zhao, Ting, Zhou, Jianhua, Porco, John A., Wang, Tony T.
Publicado 2015

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

por Cencic, Regina, Carrier, Marilyn, Galicia-Vázquez, Gabriela, Bordeleau, Marie-Eve, Sukarieh, Rami, Bourdeau, Annie, Brem, Brigitte, Teodoro, Jose G., Greger, Harald, Tremblay, Michel L., Porco, John A., Pelletier, Jerry
Publicado 2009

A forward genetic screen identifies modifiers of rocaglate responsiveness

por Shen, Leo, Pugsley, Lauren, Cencic, Regina, Wang, HanChen, Robert, Francis, Naineni, Sai Kiran, Sahni, Ananya, Morin, Geneviève, Zhang, Wenhan, Nijnik, Anastasia, Porco, John A., Langlais, David, Huang, Sidong, Pelletier, Jerry
Publicado 2021

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

por Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, O’Connor, Patrick B.F., Robert, Francis, Devine, William G., Selznick, Asher, Henkel, Thomas, Merrick, William C., Brown, Lauren E., Baranov, Pavel V., Porco, John A., Pelletier, Jerry
Publicado 2020

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

por Skofler, Christina, Kleinegger, Florian, Krassnig, Stefanie, Birkl-Toeglhofer, Anna Maria, Singer, Georg, Till, Holger, Benesch, Martin, Cencic, Regina, Porco, John A., Pelletier, Jerry, Castellani, Christoph, Raicht, Andrea, Izycka-Swieszewska, Ewa, Czapiewski, Piotr, Haybaeck, Johannes
Publicado 2021

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

por Chatterjee, Sujoy, Yabaji, Shivraj M., Rukhlenko, Oleksii S., Bhattacharya, Bidisha, Waligurski, Emily, Vallavoju, Nandini, Ray, Somak, Kholodenko, Boris N., Brown, Lauren E., Beeler, Aaron B., Ivanov, Alexander R., Kobzik, Lester, Porco, John A., Kramnik, Igor
Publicado 2021

Targeting Translation Initiation by Synthetic Rocaglates for Treating MYC-driven Lymphomas

por Zhang, Xuan, Bi, Chengfeng, Lu, Ting, Zhang, Weiwei, Yue, Ting, Wang, Cheng, Tian, Tian, Zhang, Xiaoyan, Huang, Yuhua, Lunning, Matthew, Hao, Xinbao, Brown, Lauren E., Devine, William G., Vose, Julie, Porco, John A., Fu, Kai
Publicado 2019

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

por Gandin, Valentina, Masvidal, Laia, Hulea, Laura, Gravel, Simon-Pierre, Cargnello, Marie, McLaughlan, Shannon, Cai, Yutian, Balanathan, Preetika, Morita, Masahiro, Rajakumar, Arjuna, Furic, Luc, Pollak, Michael, Porco, John A., St-Pierre, Julie, Pelletier, Jerry, Larsson, Ola, Topisirovic, Ivan
Publicado 2016

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

por Schatz, Jonathan H., Oricchio, Elisa, Wolfe, Andrew L., Jiang, Man, Linkov, Irina, Maragulia, Jocelyn, Shi, Weiji, Zhang, Zhigang, Rajasekhar, Vinagolu K., Pagano, Nen C., Porco, John A., Teruya-Feldstein, Julie, Rosen, Neal, Zelenetz, Andrew D., Pelletier, Jerry, Wendel, Hans-Guido
Publicado 2011

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

por Levi-Galibov, Oshrat, Lavon, Hagar, Wassermann-Dozorets, Rina, Pevsner-Fischer, Meirav, Mayer, Shimrit, Wershof, Esther, Stein, Yaniv, Brown, Lauren E., Zhang, Wenhan, Friedman, Gil, Nevo, Reinat, Golani, Ofra, Katz, Lior H., Yaeger, Rona, Laish, Ido, Porco, John A., Sahai, Erik, Shouval, Dror S., Kelsen, David, Scherz-Shouval, Ruth
Publicado 2020

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

por Chan, Karina, Robert, Francis, Oertlin, Christian, Kapeller-Libermann, Dana, Avizonis, Daina, Gutierrez, Johana, Handly-Santana, Abram, Doubrovin, Mikhail, Park, Julia, Schoepfer, Christina, Da Silva, Brandon, Yao, Melissa, Gorton, Faith, Shi, Junwei, Thomas, Craig J., Brown, Lauren E., Porco, John A., Pollak, Michael, Larsson, Ola, Pelletier, Jerry, Chio, Iok In Christine
Publicado 2019

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

por Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, Cowen, Leah E.
Publicado 2019

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

por Wolfe, Andrew L., Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K., Sanghvi, Viraj R., Mavrakis, Konstantinos J., Jiang, Man, Roderick, Justine E., Van der Meulen, Joni, Schatz, Jonathan H., Rodrigo, Christina M., Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A., Speleman, Frank, Porco, John A., Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido
Publicado 2014

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

por Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.
Publicado 2020

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

por Shaashua, Lee, Ben-Shmuel, Aviad, Pevsner-Fischer, Meirav, Friedman, Gil, Levi-Galibov, Oshrat, Nandakumar, Subhiksha, Barki, Debra, Nevo, Reinat, Brown, Lauren E., Zhang, Wenhan, Stein, Yaniv, Lior, Chen, Kim, Han Sang, Bojmar, Linda, Jarnagin, William R., Lecomte, Nicolas, Mayer, Shimrit, Stok, Roni, Bishara, Hend, Hamodi, Rawand, Levy-Lahad, Ephrat, Golan, Talia, Porco, John A., Iacobuzio-Donahue, Christine A., Schultz, Nikolaus, Tuveson, David A., Lyden, David, Kelsen, David, Scherz-Shouval, Ruth
Publicado 2022

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

por Kearney, Sara E., Zahoránszky-Kőhalmi, Gergely, Brimacombe, Kyle R., Henderson, Mark J., Lynch, Caitlin, Zhao, Tongan, Wan, Kanny K., Itkin, Zina, Dillon, Christopher, Shen, Min, Cheff, Dorian M., Lee, Tobie D., Bougie, Danielle, Cheng, Ken, Coussens, Nathan P., Dorjsuren, Dorjbal, Eastman, Richard T., Huang, Ruili, Iannotti, Michael J., Karavadhi, Surendra, Klumpp-Thomas, Carleen, Roth, Jacob S., Sakamuru, Srilatha, Sun, Wei, Titus, Steven A., Yasgar, Adam, Zhang, Ya-Qin, Zhao, Jinghua, Andrade, Rodrigo B., Brown, M. Kevin, Burns, Noah Z., Cha, Jin K., Mevers, Emily E., Clardy, Jon, Clement, Jason A., Crooks, Peter A., Cuny, Gregory D., Ganor, Jake, Moreno, Jesus, Morrill, Lucas A., Picazo, Elias, Susick, Robert B., Garg, Neil K., Goess, Brian C., Grossman, Robert B., Hughes, Chambers C., Johnston, Jeffrey N., Joullie, Madeleine M., Kinghorn, A. Douglas, Kingston, David G.I., Krische, Michael J., Kwon, Ohyun, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mohamed, Enas, Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Brown, Lauren E., Snyder, John K., Porco, John A., Rivas, Fatima, Ross, Samir A., Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Xu, Zhengren, Shen, Ben, Shi, Wei, Stephenson, Corey R.J., Verano, Alyssa L., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Vosburg, David A., Wu, Jimmy, Wuest, William M., Zakarian, Armen, Zhang, Yufeng, Ren, Tianjing, Zuo, Zhong, Inglese, James, Michael, Sam, Simeonov, Anton, Zheng, Wei, Shinn, Paul, Jadhav, Ajit, Boxer, Matthew B., Hall, Matthew D., Xia, Menghang, Guha, Rajarshi, Rohde, Jason M.
Publicado 2018