Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

por Vukovic, Milica, Guitart, Amelie V., Sepulveda, Catarina, Villacreces, Arnaud, O'Duibhir, Eoghan, Panagopoulou, Theano I., Ivens, Alasdair, Menendez-Gonzalez, Juan, Iglesias, Juan Manuel, Allen, Lewis, Glykofrydis, Fokion, Subramani, Chithra, Armesilla-Diaz, Alejandro, Post, Annemarie E.M., Schaak, Katrin, Gezer, Deniz, So, Chi Wai Eric, Holyoake, Tessa L., Wood, Andrew, O'Carroll, Dónal, Ratcliffe, Peter J., Kranc, Kamil R.
Publicado 2015

Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

por Bardella, Chiara, Al-Dalahmah, Osama, Krell, Daniel, Brazauskas, Pijus, Al-Qahtani, Khalid, Tomkova, Marketa, Adam, Julie, Serres, Sébastien, Lockstone, Helen, Freeman-Mills, Luke, Pfeffer, Inga, Sibson, Nicola, Goldin, Robert, Schuster-Böeckler, Benjamin, Pollard, Patrick J., Soga, Tomoyoshi, McCullagh, James S., Schofield, Christopher J., Mulholland, Paul, Ansorge, Olaf, Kriaucionis, Skirmantas, Ratcliffe, Peter J., Szele, Francis G., Tomlinson, Ian
Publicado 2016

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

por Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
Publicado 2017

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

por Yamamoto, Atsushi, Hester, Joanna, Macklin, Philip S., Kawai, Kento, Uchiyama, Masateru, Biggs, Daniel, Bishop, Tammie, Bull, Katherine, Cheng, Xiaotong, Cawthorne, Eleanor, Coleman, Mathew L., Crockford, Tanya L., Davies, Ben, Dow, Lukas E., Goldin, Rob, Kranc, Kamil, Kudo, Hiromi, Lawson, Hannah, McAuliffe, James, Milward, Kate, Scudamore, Cheryl L., Soilleux, Elizabeth, Issa, Fadi, Ratcliffe, Peter J., Pugh, Chris W.
Publicado 2019

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

por Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E, Eaton, Charlotte D, Abboud, Martine I, Katz, Maximiliano J, McNeil, Helen E, Leśniak, Robert K, Hall, Charlotte, Struwe, Weston B, Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin LP, Kessler, Benedikt M, Ratcliffe, Peter J, Cockman, Matthew E, Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L, Schofield, Christopher J
Publicado 2018

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

por Sadiku, Pranvera, Willson, Joseph A., Dickinson, Rebecca S., Murphy, Fiona, Harris, Alison J., Lewis, Amy, Sammut, David, Mirchandani, Ananda S., Ryan, Eilise, Watts, Emily R., Thompson, A.A. Roger, Marriott, Helen M., Dockrell, David H., Taylor, Cormac T., Schneider, Martin, Maxwell, Patrick H., Chilvers, Edwin R., Mazzone, Massimilliano, Moral, Veronica, Pugh, Chris W., Ratcliffe, Peter J., Schofield, Christopher J., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., Walmsley, Sarah R.
Publicado 2017

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

por Wing, Peter A.C., Keeley, Thomas P., Zhuang, Xiaodong, Lee, Jeffrey Y., Prange-Barczynska, Maria, Tsukuda, Senko, Morgan, Sophie B., Harding, Adam C., Argles, Isobel L.A., Kurlekar, Samvid, Noerenberg, Marko, Thompson, Craig P., Huang, Kuan-Ying A., Balfe, Peter, Watashi, Koichi, Castello, Alfredo, Hinks, Timothy S.C., James, William, Ratcliffe, Peter J., Davis, Ilan, Hodson, Emma J., Bishop, Tammie, McKeating, Jane A.
Publicado 2021

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

por Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.
Publicado 2022

Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

por Mirchandani, Ananda S., Jenkins, Stephen J., Bain, Calum C., Sanchez-Garcia, Manuel A., Lawson, Hannah, Coelho, Patricia, Murphy, Fiona, Griffith, David M., Zhang, Ailiang, Morrison, Tyler, Ly, Tony, Arienti, Simone, Sadiku, Pranvera, Watts, Emily R., Dickinson, Rebecca. S., Reyes, Leila, Cooper, George, Clark, Sarah, Lewis, David, Kelly, Van, Spanos, Christos, Musgrave, Kathryn M., Delaney, Liam, Harper, Isla, Scott, Jonathan, Parkinson, Nicholas J., Rostron, Anthony J., Baillie, J. Kenneth, Clohisey, Sara, Pridans, Clare, Campana, Lara, Lewis, Philip Starkey, Simpson, A. John, Dockrell, David H., Schwarze, Jürgen, Hirani, Nikhil, Ratcliffe, Peter J., Pugh, Christopher W., Kranc, Kamil, Forbes, Stuart J., Whyte, Moira K. B., Walmsley, Sarah R.
Publicado 2022

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

por Taylor, Jenny C, Martin, Hilary C, Lise, Stefano, Broxholme, John, Cazier, Jean-Baptiste, Rimmer, Andy, Kanapin, Alexander, Lunter, Gerton, Fiddy, Simon, Allan, Chris, Aricescu, A. Radu, Attar, Moustafa, Babbs, Christian, Becq, Jennifer, Beeson, David, Bento, Celeste, Bignell, Patricia, Blair, Edward, Buckle, Veronica J, Bull, Katherine, Cais, Ondrej, Cario, Holger, Chapel, Helen, Copley, Richard R, Cornall, Richard, Craft, Jude, Dahan, Karin, Davenport, Emma E, Dendrou, Calliope, Devuyst, Olivier, Fenwick, Aimée L, Flint, Jonathan, Fugger, Lars, Gilbert, Rodney D, Goriely, Anne, Green, Angie, Greger, Ingo H., Grocock, Russell, Gruszczyk, Anja V, Hastings, Robert, Hatton, Edouard, Higgs, Doug, Hill, Adrian, Holmes, Chris, Howard, Malcolm, Hughes, Linda, Humburg, Peter, Johnson, David, Karpe, Fredrik, Kingsbury, Zoya, Kini, Usha, Knight, Julian C, Krohn, Jonathan, Lamble, Sarah, Langman, Craig, Lonie, Lorne, Luck, Joshua, McCarthy, Davis, McGowan, Simon J, McMullin, Mary Frances, Miller, Kerry A, Murray, Lisa, Németh, Andrea H, Nesbit, M Andrew, Nutt, David, Ormondroyd, Elizabeth, Oturai, Annette Bang, Pagnamenta, Alistair, Patel, Smita Y, Percy, Melanie, Petousi, Nayia, Piazza, Paolo, Piret, Sian E, Polanco-Echeverry, Guadalupe, Popitsch, Niko, Powrie, Fiona, Pugh, Chris, Quek, Lynn, Robbins, Peter A, Robson, Kathryn, Russo, Alexandra, Sahgal, Natasha, van Schouwenburg, Pauline A, Schuh, Anna, Silverman, Earl, Simmons, Alison, Sørensen, Per Soelberg, Sweeney, Elizabeth, Taylor, John, Thakker, Rajesh V, Tomlinson, Ian, Trebes, Amy, Twigg, Stephen RF, Uhlig, Holm H, Vyas, Paresh, Vyse, Tim, Wall, Steven A, Watkins, Hugh, Whyte, Michael P, Witty, Lorna, Wright, Ben, Yau, Chris, Buck, David, Humphray, Sean, Ratcliffe, Peter J, Bell, John I, Wilkie, Andrew OM, Bentley, David, Donnelly, Peter, McVean, Gilean
Publicado 2015