The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia

by Rusyn, Lisa, Reinartz, Sebastian, Nikiforov, Anastasia, Mikhael, Nelly, vom Stein, Alexander, Kohlhas, Viktoria, Bloehdorn, Johannes, Stilgenbauer, Stephan, Lohneis, Philipp, Buettner, Reinhard, Robrecht, Sandra, Fischer, Kirsten, Pallasch, Christian, Hallek, Michael, Nguyen, Phuong-Hien, Seeger-Nukpezah, Tamina
Published 2022

Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

by Braig, Friederike, März, Manuela, Schieferdecker, Aneta, Schulte, Alexander, Voigt, Mareike, Stein, Alexander, Grob, Tobias, Alawi, Malik, Indenbirken, Daniela, Kriegs, Malte, Engel, Erik, Vanhoefer, Udo, Grundhoff, Adam, Loges, Sonja, Riecken, Kristoffer, Fehse, Boris, Bokemeyer, Carsten, Binder, Mascha
Published 2015

Ipilimumab or FOLFOX with Nivolumab and Trastuzumab in previously untreated HER2-positive locally advanced or metastatic EsophagoGastric Adenocarcinoma - the randomized phase 2 INT...

by Tintelnot, Joseph, Goekkurt, Eray, Binder, Mascha, Thuss-Patience, Peter, Lorenzen, Sylvie, Knorrenschild, Jorge Riera, Kretzschmar, Albrecht, Ettrich, Thomas, Lindig, Udo, Jacobasch, Lutz, Pink, Daniel, Al-Batran, Salah-Eddin, Hinke, Axel, Hegewisch-Becker, Susanna, Nilsson, Sven, Bokemeyer, Carsten, Stein, Alexander
Published 2020

Non-viral TRAC-knocked-in CD19(KI)CAR-T and gp350(KI)CAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency

by Braun, Tobias, Pruene, Alina, Darguzyte, Milita, vom Stein, Alexander F., Nguyen, Phuong-Hien, Wagner, Dimitrios L., Kath, Jonas, Roig-Merino, Alicia, Heuser, Michael, Riehm, Lucas L., Schneider, Andreas, Awerkiew, Sabine, Talbot, Steven R., Bleich, André, Figueiredo, Constanca, Bornhäuser, Martin, Stripecke, Renata
Published 2023

Dabrafenib plus trametinib in patients with relapsed/refractory BRAF V600E mutation–positive hairy cell leukemia

by Kreitman, Robert J., Moreau, Philippe, Ravandi, Farhad, Hutchings, Martin, Gazzah, Anas, Michallet, Anne-Sophie, Wainberg, Zev A., Stein, Alexander, Dietrich, Sascha, de Jonge, Maja J. A., Willenbacher, Wolfgang, De Grève, Jacques, Arons, Evgeny, Ilankumaran, Palanichamy, Burgess, Paul, Gasal, Eduard, Subbiah, Vivek
Published 2023

Multi-omic based molecular profiling of advanced cancer identifies treatable targets and improves survival in individual patients

by Samsen, Alexandra, von der Heyde, Silvia, Bokemeyer, Carsten, David, Kerstin A., Flath, Bernd, Graap, Max, Grebenstein, Bianca, Heflik, Ludger, Hollburg, Wiebke, Layer, Peter, von Leitner, Eike, Overkamp, Friedrich, Saeger, Wolfgang, Schneider, Sandra, von Seydewitz, Cay-Uwe, Stang, Axel, Stein, Alexander, Zornig, Carsten, Juhl, Hartmut
Published 2018

Pembrolizumab and trastuzumab in combination with FLOT in the perioperative treatment of HER2-positive, localized esophagogastric adenocarcinoma—a phase II trial of the AIO study g...

by Tintelnot, Joseph, Stein, Alexander, Al-Batran, Salah-Eddin, Ettrich, Thomas, Götze, Thorsten, Grün, Barbara, Haag, Georg Martin, Heuer, Vera, Hofheinz, Ralf-Dieter, Homann, Nils, Bröring, Tobias Sebastian, Cruz, Mariana Santos, Kurreck, Annika, Lorenzen, Sylvie, Moosmann, Nicolas, Müller, Christian, Schuler, Markus, Siegler, Gabriele, Binder, Mascha, Gökkurt, Eray
Published 2023

Dietary mineral supplies in Africa

by Joy, Edward J M, Ander, E Louise, Young, Scott D, Black, Colin R, Watts, Michael J, Chilimba, Allan D C, Chilima, Benson, Siyame, Edwin W P, Kalimbira, Alexander A, Hurst, Rachel, Fairweather-Tait, Susan J, Stein, Alexander J, Gibson, Rosalind S, White, Philip J, Broadley, Martin R
Published 2014

Landscape of Biomarkers and Actionable Gene Alterations in Adenocarcinoma of GEJ and Stomach—A Real World Data Analysis

by Hempel, Louisa, de Oliveira, Julia Veloso, Gaumann, Andreas, Milani, Valeria, Schweneker, Katrin, Schenck, Kristina, Fleischmann, Bastian, Philipp, Patrick, Mederle, Stefanie, Garg, Arun, Piehler, Armin, Gandorfer, Beate, Schick, Cordula, Kleespies, Axel, Sellmann, Ludger, Bartels, Marius, Goetze, Thorsten Oliver, Stein, Alexander, Goekkurt, Eray, Pfitzner, Lucia, Robert, Sebastian, Hempel, Dirk
Published 2021

Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi

by Hurst, Rachel, Siyame, Edwin W. P., Young, Scott D., Chilimba, Allan D. C., Joy, Edward J. M., Black, Colin R., Ander, E. Louise, Watts, Michael J., Chilima, Benson, Gondwe, Jellita, Kang'ombe, Dalitso, Stein, Alexander J., Fairweather-Tait, Susan J., Gibson, Rosalind S., Kalimbira, Alexander A., Broadley, Martin R.
Published 2013

LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

by vom Stein, Alexander F., Rebollido-Rios, Rocio, Lukas, Anna, Koch, Maximilian, von Lom, Anton, Reinartz, Sebastian, Bachurski, Daniel, Rose, France, Bozek, Katarzyna, Abdallah, Ali T., Kohlhas, Viktoria, Saggau, Julia, Zölzer, Rebekka, Zhao, Yue, Bruns, Christiane, Bröckelmann, Paul J., Lohneis, Philipp, Büttner, Reinhard, Häupl, Björn, Oellerich, Thomas, Nguyen, Phuong-Hien, Hallek, Michael
Published 2023

PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer

by Stein, Alexander, Simnica, Donjete, Schultheiß, Christoph, Scholz, Rebekka, Tintelnot, Joseph, Gökkurt, Eray, von Wenserski, Lisa, Willscher, Edith, Paschold, Lisa, Sauer, Markus, Lorenzen, Sylvie, Riera-Knorrenschild, Jorge, Depenbusch, Reinhard, Ettrich, Thomas J, Dörfel, Steffen, Al-Batran, Salah-Eddin, Karthaus, Meinolf, Pelzer, Uwe, Waberer, Lisa, Hinke, Axel, Bauer, Marcus, Massa, Chiara, Seliger, Barbara, Wickenhauser, Claudia, Bokemeyer, Carsten, Hegewisch-Becker, Susanna, Binder, Mascha
Published 2021

Translational analysis and final efficacy of the AVETUX trial – Avelumab, cetuximab and FOLFOX in metastatic colorectal cancer

by Tintelnot, Joseph, Ristow, Inka, Sauer, Markus, Simnica, Donjete, Schultheiß, Christoph, Scholz, Rebekka, Goekkurt, Eray, von Wenserski, Lisa, Willscher, Edith, Paschold, Lisa, Lorenzen, Sylvie, Riera-Knorrenschild, Jorge, Depenbusch, Reinhard, Ettrich, Thomas J., Dörfel, Steffen, Al-Batran, Salah-Eddin, Karthaus, Meinolf, Pelzer, Uwe, Hinke, Axel, Bauer, Marcus, Massa, Chiara, Seliger, Barbara, Wickenhauser, Claudia, Bokemeyer, Carsten, Hegewisch-Becker, Susanna, Binder, Mascha, Stein, Alexander
Published 2022

Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial

by Subbiah, Vivek, Kreitman, Robert J., Wainberg, Zev A., Gazzah, Anas, Lassen, Ulrik, Stein, Alexander, Wen, Patrick Y., Dietrich, Sascha, de Jonge, Maja J. A., Blay, Jean-Yves, Italiano, Antoine, Yonemori, Kan, Cho, Daniel C., de Vos, Filip Y. F. L., Moreau, Philippe, Fernandez, Elena Elez, Schellens, Jan H. M., Zielinski, Christoph C., Redhu, Suman, Boran, Aislyn, Passos, Vanessa Q., Ilankumaran, Palanichamy, Bang, Yung-Jue
Published 2023

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

by Tintelnot, Joseph, Xu, Yang, Lesker, Till R., Schönlein, Martin, Konczalla, Leonie, Giannou, Anastasios D., Pelczar, Penelope, Kylies, Dominik, Puelles, Victor G., Bielecka, Agata A., Peschka, Manuela, Cortesi, Filippo, Riecken, Kristoffer, Jung, Maximilian, Amend, Lena, Bröring, Tobias S., Trajkovic-Arsic, Marija, Siveke, Jens T., Renné, Thomas, Zhang, Danmei, Boeck, Stefan, Strowig, Till, Uzunoglu, Faik G., Güngör, Cenap, Stein, Alexander, Izbicki, Jakob R., Bokemeyer, Carsten, Sinn, Marianne, Kimmelman, Alec C., Huber, Samuel, Gagliani, Nicola
Published 2023

A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain

by Joglekar, Anoushka, Prjibelski, Andrey, Mahfouz, Ahmed, Collier, Paul, Lin, Susan, Schlusche, Anna Katharina, Marrocco, Jordan, Williams, Stephen R., Haase, Bettina, Hayes, Ashley, Chew, Jennifer G., Weisenfeld, Neil I., Wong, Man Ying, Stein, Alexander N., Hardwick, Simon A., Hunt, Toby, Wang, Qi, Dieterich, Christoph, Bent, Zachary, Fedrigo, Olivier, Sloan, Steven A., Risso, Davide, Jarvis, Erich D., Flicek, Paul, Luo, Wenjie, Pitt, Geoffrey S., Frankish, Adam, Smit, August B., Ross, M. Elizabeth, Tilgner, Hagen U.
Published 2021

IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

by Kempski, Jan, Giannou, Anastasios D., Riecken, Kristoffer, Zhao, Lilan, Steglich, Babett, Lücke, Jöran, Garcia-Perez, Laura, Karstens, Karl-Frederick, Wöstemeier, Anna, Nawrocki, Mikolaj, Pelczar, Penelope, Witkowski, Mario, Nilsson, Sven, Konczalla, Leonie, Shiri, Ahmad Mustafa, Kempska, Joanna, Wahib, Ramez, Brockmann, Leonie, Huber, Philipp, Gnirck, Ann-Christin, Turner, Jan-Eric, Zazara, Dimitra E., Arck, Petra C., Stein, Alexander, Simon, Ronald, Daubmann, Anne, Meiners, Jan, Perez, Daniel, Strowig, Till, Koni, Pandelakis, Kruglov, Andrey A., Sauter, Guido, Izbicki, Jakob R., Guse, Andreas H., Rösch, Thomas, Lohse, Ansgar W., Flavell, Richard A., Gagliani, Nicola, Huber, Samuel
Published 2020