XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway

por Chen, Xi, Iliopoulos, Dimitrios, Zhang, Qing, Tang, Qianzi, Greenblatt, Matthew B., Hatziapostolou, Maria, Lim, Elgene, Tam, Wai Leong, Ni, Min, Chen, Yiwen, Mai, Junhua, Shen, Haifa, Hu, Dorothy Z., Adoro, Stanley, Hu, Bella, Song, Minkyung, Tan, Chen, Landis, Melissa D., Ferrari, Mauro, Shin, Sandra J., Brown, Myles, Chang, Jenny C., Liu, X. Shirley, Glimcher, Laurie H.
Publicado 2014

Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression

por Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Shyh-Chang, Ng, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing
Publicado 2016

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer

por Nanjo, Shigeki, Wu, Wei, Karachaliou, Niki, Blakely, Collin M., Suzuki, Junji, Chou, Yu-Ting, Ali, Siraj M., Kerr, D. Lucas, Olivas, Victor R., Shue, Jonathan, Rotow, Julia, Mayekar, Manasi K., Haderk, Franziska, Chatterjee, Nilanjana, Urisman, Anatoly, Yeo, Jia Chi, Skanderup, Anders J., Tan, Aaron C., Tam, Wai Leong, Arrieta, Oscar, Hosomichi, Kazuyoshi, Nishiyama, Akihiro, Yano, Seiji, Kirichok, Yuriy, Tan, Daniel S.W., Rosell, Rafael, Okimoto, Ross A, Bivona, Trever G.
Publicado 2022

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

por Zhang, Jieqiong, Hu, Zhenhua, Chung, Hwa Hwa, Tian, Yun, Lau, Kah Weng, Ser, Zheng, Lim, Yan Ting, Sobota, Radoslaw M., Leong, Hwei Fen, Chen, Benjamin Jieming, Yeo, Clarisse Jingyi, Tan, Shawn Ying Xuan, Kang, Jian, Tan, Dennis Eng Kiat, Sou, Ieng Fong, McClurg, Urszula Lucja, Lakshmanan, Manikandan, Vaiyapuri, Thamil Selvan, Raju, Anandhkumar, Wong, Esther Sook Miin, Tergaonkar, Vinay, Rajarethinam, Ravisankar, Pathak, Elina, Tam, Wai Leong, Tan, Ern Yu, Tee, Wee-Wei
Publicado 2023

Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma

por Kaya, Neslihan Arife, Tai, David, Lim, Xinru, Lim, Jia Qi, Lau, Mai Chan, Goh, Denise, Phua, Cheryl Zi Jin, Wee, Felicia Yu Ting, Joseph, Craig Ryan, Lim, Jeffrey Chun Tatt, Neo, Zhen Wei, Ye, Jiangfeng, Cheung, Lawrence, Lee, Joycelyn, Loke, Kelvin S H, Gogna, Apoorva, Yao, Fei, Lee, May Yin, Shuen, Timothy Wai Ho, Toh, Han Chong, Hilmer, Axel, Chan, Yun Shen, Lim, Tony Kiat-Hon, Tam, Wai Leong, Choo, Su Pin, Yeong, Joe, Zhai, Weiwei
Publicado 2023

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

por Nahar, Rahul, Zhai, Weiwei, Zhang, Tong, Takano, Angela, Khng, Alexis J., Lee, Yin Yeng, Liu, Xingliang, Lim, Chong Hee, Koh, Tina P. T., Aung, Zaw Win, Lim, Tony Kiat Hon, Veeravalli, Lavanya, Yuan, Ju, Teo, Audrey S. M., Chan, Cheryl X., Poh, Huay Mei, Chua, Ivan M. L., Liew, Audrey Ann, Lau, Dawn Ping Xi, Kwang, Xue Lin, Toh, Chee Keong, Lim, Wan-Teck, Lim, Bing, Tam, Wai Leong, Tan, Eng-Huat, Hillmer, Axel M., Tan, Daniel S. W.
Publicado 2018

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

por Ho, Teresa Lai Fong, Lee, May Yin, Goh, Hui Chin, Ng, Germaine Yi Ning, Lee, Jane Jia Hui, Kannan, Srinivasaraghavan, Lim, Yan Ting, Zhao, Tianyun, Lim, Edwin Kok Hao, Phua, Cheryl Zi Jin, Lee, Yi Fei, Lim, Rebecca Yi Xuan, Ng, Perry Jun Hao, Yuan, Ju, Chan, Dedrick Kok Hong, Lieske, Bettina, Chong, Choon Seng, Lee, Kuok Chung, Lum, Jeffrey, Cheong, Wai Kit, Yeoh, Khay Guan, Tan, Ker Kan, Sobota, Radoslaw M., Verma, Chandra S., Lane, David P., Tam, Wai Leong, Venkitaraman, Ashok R.
Publicado 2023

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

por Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, Chew, Valerie
Publicado 2021

Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

por Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Bonney, Glen K., Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, Chew, Valerie
Publicado 2021

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

por Loo, Ser Yue, Toh, Li Ping, Xie, William Haowei, Pathak, Elina, Tan, Wilson, Ma, Siming, Lee, May Yin, Shatishwaran, S., Yeo, Joanna Zhen Zhen, Yuan, Ju, Ho, Yin Ying, Peh, Esther Kai Lay, Muniandy, Magendran, Torta, Federico, Chan, Jack, Tan, Tira J., Sim, Yirong, Tan, Veronique, Tan, Benita, Madhukumar, Preetha, Yong, Wei Sean, Ong, Kong Wee, Wong, Chow Yin, Tan, Puay Hoon, Yap, Yoon Sim, Deng, Lih-Wen, Dent, Rebecca, Foo, Roger, Wenk, Markus R., Lee, Soo Chin, Ho, Ying Swan, Lim, Elaine Hsuen, Tam, Wai Leong
Publicado 2021

A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC

por Lai, Gillianne G.Y., Yeo, Jia Chi, Jain, Amit, Zhou, Siqin, Pang, Mengyuan, Alvarez, Jacob J.S., Sim, Ngak Leng, Tan, Aaron C., Suteja, Lisda, Lim, Tze Wei, Guo, Yu Amanda, Shen, Meixin, Saw, Stephanie P.L., Rohatgi, Neha, Yeong, Joe P.S., Takano, Angela, Lim, Kiat Hon, Gogna, Apoorva, Too, Chow Wei, Da Zhuang, Kun, Tan, Wan Ling, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Wang, Lanying, Toh, Chee Keong, Lim, Wan-Teck, Tam, Wai Leong, Tan, Sze Huey, Skanderup, Anders M.J., Tan, Eng-Huat, Tan, Daniel S.W.
Publicado 2022

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

por Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Suthen, Sheena D/O, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie
Publicado 2022

Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

por Chua, Khi Pin, Teng, Yvonne H.F., Tan, Aaron C., Takano, Angela, Alvarez, Jacob J.S., Nahar, Rahul, Rohatgi, Neha, Lai, Gillianne G.Y., Aung, Zaw Win, Yeong, Joe P.S., Lim, Kiat Hon, Naeini, Marjan Mojtabavi, Kassam, Irfahan, Jain, Amit, Tan, Wan Ling, Gogna, Apoorva, Too, Chow Wei, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Anantham, Devanand, Phua, Ghee Chee, Tan, Bien Soo, Lee, Yin Yeng, Wang, Lanying, Teo, Audrey S.M., Khng, Alexis Jiaying, Lim, Ming Jie, Suteja, Lisda, Toh, Chee Keong, Lim, Wan-Teck, Iyer, N. Gopalakrishna, Tam, Wai Leong, Tan, Eng-Huat, Zhai, Weiwei, Hillmer, Axel M., Skanderup, Anders J., Tan, Daniel S.W.
Publicado 2021

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study

por Zhai, Weiwei, Lai, Hannah, Kaya, Neslihan Arife, Chen, Jianbin, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Alvarez, Jacob Josiah Santiago, Chen, Pauline Jieqi, Chang, Mei Mei, Wu, Lingyan, Goh, Brian K P, Chung, Alexander Yaw-Fui, Chan, Chung Yip, Cheow, Peng Chung, Lee, Ser Yee, Kam, Juinn Huar, Kow, Alfred Wei-Chieh, Ganpathi, Iyer Shridhar, Chanwat, Rawisak, Thammasiri, Jidapa, Yoong, Boon Koon, Ong, Diana Bee-Lan, de Villa, Vanessa H, Dela Cruz, Rouchelle D, Loh, Tracy Jiezhen, Wan, Wei Keat, Zeng, Zeng, Skanderup, Anders Jacobsen, Pang, Yin Huei, Madhavan, Krishnakumar, Lim, Tony Kiat-Hon, Bonney, Glenn, Leow, Wei Qiang, Chew, Valerie, Dan, Yock Young, Tam, Wai Leong, Toh, Han Chong, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Publicado 2021