Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

por Collerton, Joanna, Davies, Karen, Jagger, Carol, Kingston, Andrew, Bond, John, Eccles, Martin P, Robinson, Louise A, Martin-Ruiz, Carmen, von Zglinicki, Thomas, James, Oliver F W, Kirkwood, Thomas B L
Publicado 2009

Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old

por Wiley, Laura, Ashok, Deepthi, Martin-Ruiz, Carmen, Talbot, Duncan C. S., Collerton, Joanna, Kingston, Andrew, Davies, Karen, Chinnery, Patrick F., Catt, Michael, Jagger, Carol, Kirkwood, Thomas B. L., von Zglinicki, Thomas
Publicado 2014

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

por Passos, João F, Saretzki, Gabriele, Ahmed, Shaheda, Nelson, Glyn, Richter, Torsten, Peters, Heiko, Wappler, Ilka, Birket, Matthew J, Harold, Graham, Schaeuble, Karin, Birch-Machin, Mark A, Kirkwood, Thomas B. L, von Zglinicki, Thomas
Publicado 2007

Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study

por Martin-Ruiz, Carmen, Williams-Gray, Caroline H., Yarnall, Alison J., Boucher, John J., Lawson, Rachael A., Wijeyekoon, Ruwani S., Barker, Roger A., Kolenda, Claire, Parker, Craig, Burn, David J., Von Zglinicki, Thomas, Saretzki, Gabriele
Publicado 2020

Feedback between p21 and reactive oxygen production is necessary for cell senescence

por Passos, João F, Nelson, Glyn, Wang, Chunfang, Richter, Torsten, Simillion, Cedric, Proctor, Carole J, Miwa, Satomi, Olijslagers, Sharon, Hallinan, Jennifer, Wipat, Anil, Saretzki, Gabriele, Rudolph, Karl Lenhard, Kirkwood, Tom B L, von Zglinicki, Thomas
Publicado 2010

Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients

por Hoffmann, Jedrzej, Shmeleva, Evgeniya V., Boag, Stephen E., Fiser, Karel, Bagnall, Alan, Murali, Santosh, Dimmick, Ian, Pircher, Hanspeter, Martin-Ruiz, Carmen, Egred, Mohaned, Keavney, Bernard, von Zglinicki, Thomas, Das, Rajiv, Todryk, Stephen, Spyridopoulos, Ioakim
Publicado 2015

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

por Langie, Sabine A. S., Cameron, Kerry M., Ficz, Gabriella, Oxley, David, Tomaszewski, Bartłomiej, Gorniak, Joanna P., Maas, Lou M., Godschalk, Roger W. L., van Schooten, Frederik J., Reik, Wolf, von Zglinicki, Thomas, Mathers, John C.
Publicado 2017

Bioengineering the microanatomy of human skin

por Roger, Mathilde, Fullard, Nicola, Costello, Lydia, Bradbury, Steven, Markiewicz, Ewa, O'Reilly, Steven, Darling, Nicole, Ritchie, Pamela, Määttä, Arto, Karakesisoglou, Iakowos, Nelson, Glyn, von Zglinicki, Thomas, Dicolandrea, Teresa, Isfort, Robert, Bascom, Charles, Przyborski, Stefan
Publicado 2019

Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis

por Gardner, Michael P., Martin-Ruiz, Carmen, Cooper, Rachel, Hardy, Rebecca, Sayer, Avan Aihie, Cooper, Cyrus, Deary, Ian J., Gallacher, John, Harris, Sarah E., Shiels, Paul G., Starr, John M., Kuh, Diana, von Zglinicki, Thomas, Ben-Shlomo, Yoav
Publicado 2013

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

por Carroll, Bernadette, Nelson, Glyn, Rabanal-Ruiz, Yoana, Kucheryavenko, Olena, Dunhill-Turner, Natasha A., Chesterman, Charlotte C., Zahari, Qabil, Zhang, Tong, Conduit, Sarah E., Mitchell, Christina A., Maddocks, Oliver D.K., Lovat, Penny, von Zglinicki, Thomas, Korolchuk, Viktor I.
Publicado 2017

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

por Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Publicado 2016

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

por Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Publicado 2014

Aging and chronic inflammation: highlights from a multidisciplinary workshop

por Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J., Pereira, Karla, Robbins, Paul D., Silva, Alexa, Suarez, Gisela M., Berghe, Wim Vanden, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín
Publicado 2023

MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of...

por Rennie, Katherine J, Witham, Miles, Bradley, Penny, Clegg, Andrew, Connolly, Stephen, Hancock, Helen C, Hiu, Shaun, Marsay, Leanne, McDonald, Claire, Robertson, Laura, Simms, Laura, Steel, Alison J, Steves, Claire J, Storey, Bryony, Wason, James, Wilson, Nina, von Zglinicki, Thomas, Sayer, Avan A P
Publicado 2022

Cellular senescence drives age-dependent hepatic steatosis

por Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana
Publicado 2017

An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence

por Riviere-Cazaux, Cecile, Carlstrom, Lucas P., Neth, Bryan J., Olson, Ian E., Rajani, Karishma, Rahman, Masum, Ikram, Samar, Mansour, Moustafa A., Mukherjee, Bipasha, Warrington, Arthur E., Short, Susan C., von Zglinicki, Thomas, Brown, Desmond A., Burma, Sandeep, Tchkonia, Tamar, Schafer, Marissa J., Baker, Darren J., Kizilbash, Sani H., Kirkland, James L., Burns, Terry C.
Publicado 2023

Reproducibility of telomere length assessment: an international collaborative study

por Martin-Ruiz, Carmen M, Baird, Duncan, Roger, Laureline, Boukamp, Petra, Krunic, Damir, Cawthon, Richard, Dokter, Martin M, van der Harst, Pim, Bekaert, Sofie, de Meyer, Tim, Roos, Goran, Svenson, Ulrika, Codd, Veryan, Samani, Nilesh J, McGlynn, Liane, Shiels, Paul G, Pooley, Karen A, Dunning, Alison M, Cooper, Rachel, Wong, Andrew, Kingston, Andrew, von Zglinicki, Thomas
Publicado 2015

Reproducibility of Telomere Length Assessment - An International Collaborative Study

por Martin-Ruiz, Carmen M., Baird, Duncan, Roger, Laureline, Boukamp, Petra, Krunic, Damir, Cawthon, Richard, Dokter, Martin M, van der Harst, Pim, Bekaert, Sofie, de Meyer, Tim, Roos, Goran, Svenson, Ulrika, Codd, Veryan, Samani, Nilesh J, McGlynn, Liane, Shiels, Paul G, Pooley, Karen A, Dunning, Alison M, Cooper, Rachel, Wong, Andrew, Kingston, Andrew, von Zglinicki, Thomas
Publicado 2015

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

por Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana
Publicado 2019

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

por Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana
Publicado 2019