P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

por Wang, Yaogeng, Sparidans, Rolf W., Potters, Sander, Şentürk, Rahime, Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2021