Multiple Regulatory Roles of the Mouse Transmembrane Adaptor Protein NTAL in Gene Transcription and Mast Cell Physiology

por Polakovicova, Iva, Draberova, Lubica, Simicek, Michal, Draber, Petr
Publicado 2014

Mechanism of phospho-ubiquitin induced PARKIN activation

por Wauer, Tobias, Simicek, Michal, Schubert, Alexander, Komander, David
Publicado 2015

Length-Dependent Translation Efficiency of ER-Destined Proteins

por Sahinbegovic, Hana, Vdovin, Alexander, Snaurova, Renata, Durech, Michal, Nezval, Jakub, Sobotka, Jiri, Hajek, Roman, Jelinek, Tomas, Simicek, Michal
Publicado 2023

A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

por Motais, Benjamin, Charvátová, Sandra, Hrdinka, Matouš, Šimíček, Michal, Jelínek, Tomáš, Ševčíková, Tereza, Kořístek, Zdeněk, Hájek, Roman, Bagó, Juli R.
Publicado 2020

Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins

por Morrow, Marie E, Morgan, Michael T, Clerici, Marcello, Growkova, Katerina, Yan, Ming, Komander, David, Sixma, Titia K, Simicek, Michal, Wolberger, Cynthia
Publicado 2018

Intercellular Mitochondrial Transfer in the Tumor Microenvironment

por Sahinbegovic, Hana, Jelinek, Tomas, Hrdinka, Matous, Bago, Juli R., Turi, Marcello, Sevcikova, Tereza, Kurtovic-Kozaric, Amina, Hajek, Roman, Simicek, Michal
Publicado 2020

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

por Celichowski, Piotr, Turi, Marcello, Charvátová, Sandra, Radhakrishnan, Dhwani, Feizi, Neda, Chyra, Zuzana, Šimíček, Michal, Jelínek, Tomáš, Bago, Juli Rodriguez, Hájek, Roman, Hrdinka, Matouš
Publicado 2023

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

por Michel, Martin A., Elliott, Paul R., Swatek, Kirby N., Simicek, Michal, Pruneda, Jonathan N., Wagstaff, Jane L., Freund, Stefan M.V., Komander, David
Publicado 2015

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

por Baietti, Maria Francesca, Simicek, Michal, Abbasi Asbagh, Layka, Radaelli, Enrico, Lievens, Sam, Crowther, Jonathan, Steklov, Mikhail, Aushev, Vasily N, Martínez García, David, Tavernier, Jan, Sablina, Anna A
Publicado 2016

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

por Vdovin, Alexander, Jelinek, Tomas, Zihala, David, Sevcikova, Tereza, Durech, Michal, Sahinbegovic, Hana, Snaurova, Renata, Radhakrishnan, Dhwani, Turi, Marcello, Chyra, Zuzana, Popkova, Tereza, Venglar, Ondrej, Hrdinka, Matous, Hajek, Roman, Simicek, Michal
Publicado 2022

PB2397: TRANSCRIPTOME ANALYSIS OF DIFFUSE LARGE B-CELL LYMPHOMA CELLS EXPRESSING MYD88 L265P REVEALS CD44, LGALS3, NFKBIZ AND BATF AS DOWNSTREAM TARGETS OF ONCOGENIC NF-ΚB SIGNALIN...

por Turi, Marcello, Anilkumar Sithara, Anjana, Hofmanová, Lucie, Žihala, David, Radhakrishnan, Dhwani, Vdovin, Alexander, Knápková, Sofija, Ševčíková, Tereza, Chyra, Zuzana, Jelínek, Tomas, Šimíček, Michal, Gullà, Annamaria, Anderson, Kenneth, Hájek, Roman, Hrdinka, Matous
Publicado 2023

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment

por Motais, Benjamin, Charvátová, Sandra, Walek, Zuzana, Hrdinka, Matouš, Smolarczyk, Ryszard, Cichoń, Tomasz, Czapla, Justyna, Giebel, Sebastian, Šimíček, Michal, Jelínek, Tomáš, Ševčíková, Tereza, Sobotka, Jiří, Kořístek, Zdeněk, Hájek, Roman, Bagó, Juli R.
Publicado 2021

Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets...

por Turi, Marcello, Anilkumar Sithara, Anjana, Hofmanová, Lucie, Žihala, David, Radhakrishnan, Dhwani, Vdovin, Alexander, Knápková, Sofija, Ševčíková, Tereza, Chyra, Zuzana, Jelínek, Tomáš, Šimíček, Michal, Gullà, Annamaria, Anderson, Kenneth Carl, Hájek, Roman, Hrdinka, Matouš
Publicado 2023

P805: EXTRAMEDULLARY MULTIPLE MYELOMA: MOLECULAR PATHOGENESIS AND NOVEL THERAPEUTIC TARGETS

por Zihala, David, Jelinek, Tomas, Sevcikova, Tereza, Anilkumar Sithara, Anjana, Kapustova, Veronika, Bilek, Daniel, Sahinbegovic, Hana, Popkova, Tereza, Plonkova, Hana, Broskevicova, Lucie, Venglar, Ondrej, Vrana, Jan, Zidlik, Vladimir, Havel, Martin, Koristek, Zdenek, Hrdinka, Matous, Chyra, Zuzana, Simicek, Michal, Hajek, Roman
Publicado 2023

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine

por Zátopková, Martina, Ševčíková, Tereza, Fanfani, Viola, Chyra, Zuzana, Říhová, Lucie, Bezděková, Renata, Žihala, David, Growková, Kateřina, Filipová, Jana, Černá, Lucie, Broskevičova, Lucie, Kryukov, Fedor, Minařík, Jiří, Smejkalová, Jana, Maisnar, Vladimír, Harvanová, Ĺubica, Pour, Luděk, Jungova, Alexandra, Popková, Tereza, Bago, Juli Rodriguez, Anilkumar Sithara, Anjana, Hrdinka, Matouš, Jelínek, Tomáš, Šimíček, Michal, Stracquadanio, Giovanni, Hájek, Roman
Publicado 2022

Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple Myeloma

por Haertle, Larissa, Buenache, Natalia, Cuesta Hernández, Hipólito Nicolás, Simicek, Michal, Snaurova, Renata, Rapado, Inmaculada, Martinez, Nerea, López-Muñoz, Nieves, Sánchez-Pina, José María, Munawar, Umair, Han, Seungbin, Ruiz-Heredia, Yanira, Colmenares, Rafael, Gallardo, Miguel, Sanchez-Beato, Margarita, Piris, Miguel Angel, Samur, Mehmet Kemal, Munshi, Nikhil C., Ayala, Rosa, Kortüm, Klaus Martin, Barrio, Santiago, Martínez-López, Joaquín
Publicado 2023

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia–Like Multiple Myeloma

por Jelinek, Tomas, Bezdekova, Renata, Zihala, David, Sevcikova, Tereza, Anilkumar Sithara, Anjana, Pospisilova, Lenka, Sevcikova, Sabina, Polackova, Petra, Stork, Martin, Knechtova, Zdenka, Venglar, Ondrej, Kapustova, Veronika, Popkova, Tereza, Muronova, Ludmila, Chyra, Zuzana, Hrdinka, Matous, Simicek, Michal, Garcés, Juan-Jose, Puig, Noemi, Cedena, Maria-Teresa, Jurczyszyn, Artur, Castillo, Jorge J., Penka, Miroslav, Radocha, Jakub, Mateos, Maria Victoria, San-Miguel, Jesús F., Paiva, Bruno, Pour, Ludek, Rihova, Lucie, Hajek, Roman
Publicado 2023

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

por Chyra, Zuzana, Sevcikova, Tereza, Vojta, Petr, Puterova, Janka, Brozova, Lucie, Growkova, Katerina, Filipova, Jana, Zatopkova, Martina, Grosicki, Sebastian, Barchnicka, Agnieszka, Wiktor-Jedrzejczak, Wieslaw, Waszczuk-Gajda, Anna, Jungova, Alexandra, Mikulasova, Aneta, Hajduch, Marian, Mokrejs, Martin, Pour, Ludek, Stork, Martin, Harvanova, Lubica, Mistrik, Martin, Mikala, Gabor, Robak, Pawel, Czyz, Anna, Debski, Jakub, Usnarska-Zubkiewicz, Lidia, Jurczyszyn, Artur, Stejskal, Lukas, Morgan, Gareth, Kryukov, Fedor, Budinska, Eva, Simicek, Michal, Jelinek, Tomas, Hrdinka, Matous, Hajek, Roman
Publicado 2020