Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs

por Jiráček, Jiří, Žáková, Lenka
Publicado 2017

From venom peptides to a potential diabetes treatment

por Jiráček, Jiří, Žáková, Lenka
Publicado 2019

Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young

por Křížková, Květoslava, Veverka, Václav, Maletínská, Lenka, Hexnerová, Rozálie, Brzozowski, Andrzej M., Jiráček, Jiří, Žáková, Lenka
Publicado 2014

Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation

por Kertisová, Anna, Žáková, Lenka, Macháčková, Kateřina, Marek, Aleš, Šácha, Pavel, Pompach, Petr, Jiráček, Jiří, Selicharová, Irena
Publicado 2023

A radioligand binding assay for the insulin-like growth factor 2 receptor

por Potalitsyn, Pavlo, Selicharová, Irena, Sršeň, Kryštof, Radosavljević, Jelena, Marek, Aleš, Nováková, Kateřina, Jiráček, Jiří, Žáková, Lenka
Publicado 2020

Characterization of insulin crystalline form in isolated β-cell secretory granules

por Asai, Seiya, Moravcová, Jana, Žáková, Lenka, Selicharová, Irena, Hadravová, Romana, Brzozowski, Andrzej Marek, Nováček, Jiří, Jiráček, Jiří
Publicado 2022

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

por Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Publicado 2014

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding

por Chrudinová, Martina, Žáková, Lenka, Marek, Aleš, Socha, Ondřej, Buděšínský, Miloš, Hubálek, Martin, Pícha, Jan, Macháčková, Kateřina, Jiráček, Jiří, Selicharová, Irena
Publicado 2018

Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin

por Kosinová, Lucie, Veverka, Václav, Novotná, Pavlína, Collinsová, Michaela, Urbanová, Marie, Moody, Nicholas R., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M., Žáková, Lenka
Publicado 2014

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

por Potalitsyn, Pavlo, Mrázková, Lucie, Selicharová, Irena, Tencerová, Michaela, Ferenčáková, Michaela, Chrudinová, Martina, Turnovská, Tereza, Brzozowski, Andrzej Marek, Marek, Aleš, Kaminský, Jakub, Jiráček, Jiří, Žáková, Lenka
Publicado 2023

Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

por Palivec, Vladimír, Viola, Cristina M., Kozak, Mateusz, Ganderton, Timothy R., Křížková, Květoslava, Turkenburg, Johan P., Halušková, Petra, Žáková, Lenka, Jiráček, Jiří, Jungwirth, Pavel, Brzozowski, Andrzej M.
Publicado 2017

Characterization of viral insulins reveals white adipose tissue-specific effects in mice

por Chrudinová, Martina, Moreau, François, Noh, Hye Lim, Páníková, Terezie, Žáková, Lenka, Friedline, Randall H., Valenzuela, Francisco A., Kim, Jason K., Jiráček, Jiří, Kahn, C. Ronald, Altindis, Emrah
Publicado 2020

Characterization of Viral Insulin-Like Peptides Reveals Unique White Adipose Tissue Specific Characteristics

por Chrudinova, Martina, Francois, Moreau, Noh, Hye Lim, Panikova, Terezie, Zakova, Lenka, Friedline, Randall H, Alsina-Fernandez, Jorge, Kim, Jason K, Jiracek, Jiri, Kahn, Ronald C, Altindis, Emrah
Publicado 2021

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn(2+) levels

por Dzianová, Petra, Asai, Seiya, Chrudinová, Martina, Kosinová, Lucie, Potalitsyn, Pavlo, Šácha, Pavel, Hadravová, Romana, Selicharová, Irena, Kříž, Jan, Turkenburg, Johan P., Brzozowski, Andrzej Marek, Jiráček, Jiří, Žáková, Lenka
Publicado 2020

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain

por Hexnerová, Rozálie, Křížková, Květoslava, Fábry, Milan, Sieglová, Irena, Kedrová, Kateřina, Collinsová, Michaela, Ullrichová, Pavlína, Srb, Pavel, Williams, Christopher, Crump, Matthew P., Tošner, Zdeněk, Jiráček, Jiří, Veverka, Václav, Žáková, Lenka
Publicado 2016

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

por Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří
Publicado 2019

Rational steering of insulin binding specificity by intra-chain chemical crosslinking

por Viková, Jitka, Collinsová, Michaela, Kletvíková, Emília, Buděšínský, Miloš, Kaplan, Vojtěch, Žáková, Lenka, Veverka, Václav, Hexnerová, Rozálie, Aviñó, Roberto J. Tarazona, Straková, Jana, Selicharová, Irena, Vaněk, Václav, Wright, Daniel W., Watson, Christopher J., Turkenburg, Johan P., Brzozowski, Andrzej M., Jiráček, Jiří
Publicado 2016