Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice

por Mégret, Lucile, Nair, Satish Sasidharan, Dancourt, Julia, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado 2020

Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

por Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Publicado 2020

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

por Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Publicado 2021

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

por Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Publicado 2016

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

por Lu, Ake T., Narayan, Pritika, Grant, Matthew J., Langfelder, Peter, Wang, Nan, Kwak, Seung, Wilkinson, Hilary, Chen, Richard Z., Chen, Jian, Simon Bawden, C., Rudiger, Skye R., Ciosi, Marc, Chatzi, Afroditi, Maxwell, Alastair, Hore, Timothy A., Aaronson, Jeff, Rosinski, Jim, Preiss, Alicia, Vogt, Thomas F., Coppola, Giovanni, Monckton, Darren, Snell, Russell G., William Yang, X., Horvath, Steve
Publicado 2020

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model

por Marchionini, Deanna M., Liu, Jeh-Ping, Ambesi-Impiombato, Alberto, Kerker, Kimberly, Cirillo, Kim, Bansal, Mukesh, Mushlin, Rich, Brunner, Daniela, Ramboz, Sylvie, Kwan, Mei, Kuhlbrodt, Kirsten, Tillack, Karsten, Peters, Finn, Rauhala, Leena, Obenauer, John, Greene, Jonathan R., Hartl, Christopher, Khetarpal, Vinod, Lager, Brenda, Rosinski, Jim, Aaronson, Jeff, Alam, Morshed, Signer, Ethan, Muñoz-Sanjuán, Ignacio, Howland, David, Zeitlin, Scott O.
Publicado 2022