Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives

por ElHady, Ahmed K., El-Gamil, Dalia S., Abdel-Halim, Mohammad, Abadi, Ashraf H.
Publicado 2023

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhib...

por Abadi, Ashraf H., Lehmann, Jochen, Piazza, Gary A., Abdel-Halim, Mohammad, Ali, Mohamed S. M.
Publicado 2011

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors

por Elhady, Ahmed K., Sigler, Sara C., Noureldin, Nazih, Canzoneri, Joshua C., Ahmed, Nermin S., Piazza, Gary A., Abadi, Ashraf H.
Publicado 2015

Design and Synthesis of Novel Symmetric Fluorene-2,7-Diamine Derivatives as Potent Hepatitis C Virus Inhibitors

por Mousa, Mai H. A., Ahmed, Nermin S., Schwedtmann, Kai, Frakolaki, Efseveia, Vassilaki, Niki, Zoidis, Grigoris, Weigand, Jan J., Abadi, Ashraf H.
Publicado 2021

Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds

por Leila, Alaa R. S., Mousa, Mai H. A., Frakolaki, Efseveia, Vassilaki, Niki, Bartenschlager, Ralf, Zoidis, Grigoris, Abdel-Halim, Mohammad, Abadi, Ashraf H.
Publicado 2019

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

por ElHady, Ahmed K., El-Gamil, Dalia S., Chen, Po-Jen, Hwang, Tsong-Long, Abadi, Ashraf H., Abdel-Halim, Mohammad, Engel, Matthias
Publicado 2021

Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer

por Ammar, Lina, Lin, Hung-Yu, Shih, Shou-Ping, Tsai, Tsen-Ni, Syu, Yu-Ting, Abdel-Halim, Mohammad, Hwang, Tsong-Long, Abadi, Ashraf H.
Publicado 2023

Structure–Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents

por Ahmed, Nermin S., El-Nakib, Heba E., Ramsis, Marian M., Albably, Nouran O., Wober, Jannette, Weigand, Jan J., Schwedtmann, Kai, Zierau, Oliver, Abadi, Ashraf H.
Publicado 2023

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

por Hamdy, Jehad, Emadeldin, Nouran, Hamed, Mostafa M., Frakolaki, Efseveia, Katsamakas, Sotirios, Vassilaki, Niki, Zoidis, Grigoris, Hirsch, Anna K. H., Abdel-Halim, Mohammad, Abadi, Ashraf H.
Publicado 2022

Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors

por Darwish, Sarah S., Chen, Po-Jen, Hamed, Mostafa M., Wagdy, Reem A., Chen, Shun-Hua, Abadi, Ashraf H., Abdel-Halim, Mohammad, Hwang, Tsong-Long, Engel, Matthias
Publicado 2022

Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease

por Hafez, Donia E., Dubiel, Mariam, La Spada, Gabriella, Catto, Marco, Reiner-Link, David, Syu, Yu-Ting, Abdel-Halim, Mohammad, Hwang, Tsong-Long, Stark, Holger, Abadi, Ashraf H.
Publicado 2023

Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs

por Elnakib, Heba E., Ramsis, Marian M., Albably, Nouran O., Vector, Merna A., Weigand, Jan J., Schwedtmann, Kai, Wober, Jannette, Zierau, Oliver, Vollmer, Günter, Abadi, Ashraf H., Ahmed, Nermin S.
Publicado 2021

An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

por Harms, Mirja, Habib, Monica M.W., Nemska, Simona, Nicolò, Antonella, Gilg, Andrea, Preising, Nico, Sokkar, Pandian, Carmignani, Sara, Raasholm, Martina, Weidinger, Gilbert, Kizilsavas, Gönül, Wagner, Manfred, Ständker, Ludger, Abadi, Ashraf H., Jumaa, Hassan, Kirchhoff, Frank, Frossard, Nelly, Sanchez-Garcia, Elsa, Münch, Jan
Publicado 2021

Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability

por Harms, Mirja, Fabech Hansson, Rikke, Gilg, Andrea, Almeida-Hernández, Yasser, Löffler, Jessica, Rodríguez-Alfonso, Armando, Habib, Monica M. W., Albers, Dan, Ahmed, Nermin S., Abadi, Ashraf H., Winter, Gordon, Rasche, Volker, Beer, Ambros J., Weidinger, Gilbert, Preising, Nico, Ständker, Ludger, Wiese, Sebastian, Sanchez-Garcia, Elsa, Zelikin, Alexander N., Münch, Jan
Publicado 2023