Targeting Protein–Protein Interactions in the HIF System

por Wilkins, Sarah E., Abboud, Martine I., Hancock, Rebecca L., Schofield, Christopher J.
Publicado 2016

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

por Chowdhury, Rasheduzzaman, Abboud, Martine I., Wiley, James, Tumber, Anthony, Markolovic, Suzana, Schofield, Christopher J.
Publicado 2022

Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease

por Liu, Haotian, Xie, Yong, Wang, Xia, Abboud, Martine I., Ma, Chao, Ge, Wei, Schofield, Christopher J.
Publicado 2022

Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant

por Herold, Ryan A., Reinbold, Raphael, Megarity, Clare F., Abboud, Martine I., Schofield, Christopher J., Armstrong, Fraser A.
Publicado 2021

Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation

por Hancock, Rebecca L., Abboud, Martine I., Smart, Tristan J., Flashman, Emily, Kawamura, Akane, Schofield, Christopher J., Hopkinson, Richard J.
Publicado 2018

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

por Lippl, Kerstin, Boleininger, Anna, McDonough, Michael A, Abboud, Martine I, Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Loenarz, Christoph, Schofield, Christopher J
Publicado 2018

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

por Chowdhury, Rasheduzzaman, Abboud, Martine I., McAllister, Tom E., Banerji, Biswadip, Bhushan, Bhaskar, Sorensen, John L., Kawamura, Akane, Schofield, Christopher J.
Publicado 2020

Interaction of Avibactam with Class B Metallo-β-Lactamases

por Abboud, Martine I., Damblon, Christian, Brem, Jürgen, Smargiasso, Nicolas, Mercuri, Paola, Gilbert, Bernard, Rydzik, Anna M., Claridge, Timothy D. W., Schofield, Christopher J., Frère, Jean-Marie
Publicado 2016

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

por Makena, Anne, Düzgün, Azer Ö., Brem, Jürgen, McDonough, Michael A., Rydzik, Anna M., Abboud, Martine I., Saral, Ayşegül, Çiçek, Ayşegül Ç., Sandalli, Cemal, Schofield, Christopher J.
Publicado 2016

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

por Li, Guo-Bo, Abboud, Martine I., Brem, Jürgen, Someya, Hidenori, Lohans, Christopher T., Yang, Sheng-Yong, Spencer, James, Wareham, David W., McDonough, Michael A., Schofield, Christopher J.
Publicado 2017

Cyclobutanone Mimics of Intermediates in Metallo‐β‐Lactamase Catalysis

por Abboud, Martine I., Kosmopoulou, Magda, Krismanich, Anthony P., Johnson, Jarrod W., Hinchliffe, Philip, Brem, Jürgen, Claridge, Timothy D. W., Spencer, James, Schofield, Christopher J., Dmitrienko, Gary I.
Publicado 2018

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

por Thinnes, Cyrille C., Lohans, Christopher T., Abboud, Martine I., Yeh, Tzu‐Lan, Tumber, Anthony, Nowak, Radosław P., Attwood, Martin, Cockman, Matthew E., Oppermann, Udo, Loenarz, Christoph, Schofield, Christopher J.
Publicado 2019

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells

por Walsby-Tickle, John, Gannon, Joan, Hvinden, Ingvild, Bardella, Chiara, Abboud, Martine I., Nazeer, Areesha, Hauton, David, Pires, Elisabete, Cadoux-Hudson, Tom, Schofield, Christopher J., McCullagh, James S. O.
Publicado 2020

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1

por Liu, Shuang, Abboud, Martine I., John, Tobias, Mikhailov, Victor, Hvinden, Ingvild, Walsby-Tickle, John, Liu, Xiao, Pettinati, Ilaria, Cadoux-Hudson, Tom, McCullagh, James S. O., Schofield, Christopher J.
Publicado 2021

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

por Cockman, Matthew E, Lippl, Kerstin, Tian, Ya-Min, Pegg, Hamish B, Figg, William D, Abboud, Martine I, Heilig, Raphael, Fischer, Roman, Myllyharju, Johanna, Schofield, Christopher J, Ratcliffe, Peter J
Publicado 2019

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

por Liu, Xiao, Reinbold, Raphael, Liu, Shuang, Herold, Ryan A., Rabe, Patrick, Duclos, Stéphanie, Yadav, Rahul B., Abboud, Martine I., Thieffine, Sandrine, Armstrong, Fraser A., Brewitz, Lennart, Schofield, Christopher J.
Publicado 2023

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

por Liu, Tongri, Abboud, Martine I., Chowdhury, Rasheduzzaman, Tumber, Anthony, Hardy, Adam P., Lippl, Kerstin, Lohans, Christopher T., Pires, Elisabete, Wickens, James, McDonough, Michael A., West, Christopher M., Schofield, Christopher J.
Publicado 2021

(19)F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase

por Abboud, Martine I., Hinchliffe, Philip, Brem, Jürgen, Macsics, Robert, Pfeffer, Inga, Makena, Anne, Umland, Klaus‐Daniel, Rydzik, Anna M., Li, Guo‐Bo, Spencer, James, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2017

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

por Abboud, Martine I., McAllister, Tom E., Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Jorgensen, Christian, Domene, Carmen, Mecinović, Jasmin, Lippl, Kerstin, Hancock, Rebecca L., Hopkinson, Richard J., Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2018

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

por Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2019