Clinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease

por Abdulmalik, Osheiza, Ataga, Kenneth I.
Publicado 2017

A Reverse Time-Course Method for Transcriptional Chase Analyses of mRNA Half-Lives in Cultured Cells

por Abdulmalik, Osheiza, Lombardi, Alyssa A., Russell, J. Eric
Publicado 2012

Direct comparison of oligochaete erythrocruorins as potential blood substitutes

por Zimmerman, Devon, DiIusto, Matthew, Dienes, Jack, Abdulmalik, Osheiza, Elmer, Jacob J.
Publicado 2017

Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

por Alramadhani, Dina, Aljahdali, Anfal S., Abdulmalik, Osheiza, Pierce, B. Daniel, Safo, Martin K.
Publicado 2022

Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia

por Abdulmalik, Osheiza, Darwish, Noureldien H. E., Muralidharan-Chari, Vandhana, Taleb, Maii Abu, Mousa, Shaker A.
Publicado 2021

Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b(5) reductase deficiency in cats

por Jaffey, Jared A., Reading, N. Scott, Giger, Urs, Abdulmalik, Osheiza, Buckley, Ruben M., Johnstone, Sophie, Lyons, Leslie A.
Publicado 2019

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

por Omar, Abdelsattar M., Abdulmalik, Osheiza, Ghatge, Mohini S., Muhammad, Yosra A., Paredes, Steven D., El-Araby, Moustafa E., Safo, Martin K.
Publicado 2020

Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling

por Chow, Pak Hin, Cox, Charles D., Pei, Jinxin V., Anabaraonye, Nancy, Nourmohammadi, Saeed, Henderson, Sam W., Martinac, Boris, Abdulmalik, Osheiza, Yool, Andrea J.
Publicado 2022

Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

por Alhashimi, Rana T., Ahmed, Tarek A., Alghanem, Lamya, Pagare, Piyusha P., Huang, Boshi, Ghatge, Mohini S., Omar, Abdelsattar M., Abdulmalik, Osheiza, Zhang, Yan, Safo, Martin K.
Publicado 2023

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

por Omar, Abdelsattar M., Mahran, Mona A., Ghatge, Mohini S., Bamane, Faida H. A., Ahmed, Mostafa H., El-Araby, Moustafa E., Abdulmalik, Osheiza, Safo, Martin K.
Publicado 2016

Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease

por Alhashimi, Rana T., Ghatge, Mohini S., Donkor, Akua K., Deshpande, Tanvi M., Anabaraonye, Nancy, Alramadhani, Dina, Danso-Danquah, Richmond, Huang, Boshi, Zhang, Yan, Musayev, Faik N., Abdulmalik, Osheiza, Safo, Martin K.
Publicado 2022

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum

por Abdulmalik, Osheiza, Ghatge, Mohini S., Musayev, Faik N., Parikh, Apurvasena, Chen, Qiukan, Yang, Jisheng, Nnamani, Ijeoma, Danso-Danquah, Richmond, Eseonu, Dorothy N., Asakura, Toshio, Abraham, Donald J., Venitz, Jurgen, Safo, Martin K.
Publicado 2011

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

por Abdulmalik, Osheiza, Pagare, Piyusha P., Huang, Boshi, Xu, Guoyan G., Ghatge, Mohini S., Xu, Xiaomeng, Chen, Qiukan, Anabaraonye, Nancy, Musayev, Faik N., Omar, Abdelsattar M., Venitz, Jürgen, Zhang, Yan, Safo, Martin K.
Publicado 2020

Inclusion of a short hairpin RNA targeting BCL11A into a b-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin

por Lourenco, Silvia Pires, Jarocha, Danuta, Ghiaccio, Valentina, Guerra, Amaliris, Abdulmalik, Osheiza, La, Ping, Zezulin, Alexandra, Smith-Whitley, Kim, Kwiatkowski, Janet L., Guzikowski, Virginia, Nakamura, Yukio, Raabe, Tobias, Breda, Laura, Rivella, Stefano
Publicado 2021

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

por Nakagawa, Akito, Lui, Francine E., Wassaf, Dina, Yefidoff-Freedman, Revital, Casalena, Dominick, Palmer, Michelle A., Meadows, Jacqueline, Mozzarelli, Andrea, Ronda, Luca, Abdulmalik, Osheiza, Bloch, Kenneth D., Safo, Martin K., Zapol, Warren M.
Publicado 2014

Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

por Ahmed, Tarek A., El-Say, Khalid M., Abd-Allah, Fathy I., Omar, Abdelsattar M., El-Araby, Moustafa E., Muhammad, Yosra A., Pagare, Piyusha P., Zhang, Yan, Mohmmad, Khadijah A., Abdulmalik, Osheiza, Safo, Martin K.
Publicado 2021

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

por Nakagawa, Akito, Ferrari, Michele, Schleifer, Grigorij, Cooper, Marissa K., Liu, Chen, Yu, Binglan, Berra, Lorenzo, Klings, Elizabeth S., Safo, Ronni S., Chen, Qiukan, Musayev, Faik N., Safo, Martin K., Abdulmalik, Osheiza, Bloch, Donald B., Zapol, Warren M.
Publicado 2018

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

por Huang, Boshi, Ghatge, Mohini S., Donkor, Akua K., Musayev, Faik N., Deshpande, Tanvi M., Al-Awadh, Mohammed, Alhashimi, Rana T., Zhu, Hongmei, Omar, Abdelsattar M., Telen, Marilyn J., Zhang, Yan, McMahon, Tim J., Abdulmalik, Osheiza, Safo, Martin K.
Publicado 2022

Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

por Wakabayashi, Aoi, Kihiu, Maryanne, Sharma, Malini, Thrasher, A. Josephine, Saari, Megan S., Quesnel-Vallières, Mathieu, Abdulmalik, Osheiza, Peslak, Scott A., Khandros, Eugene, Keller, Cheryl A., Giardine, Belinda M., Barash, Yoseph, Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Publicado 2022

Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

por Qin, Kunhua, Huang, Peng, Feng, Ruopeng, Keller, Cheryl A., Peslak, Scott A., Khandros, Eugene, Saari, Megan, Lan, Xianjiang, Mayuranathan, Thiyagaraj, Doerfler, Phillip A., Abdulmalik, Osheiza, Giardine, Belinda, Chou, Stella T., Shi, Junwei, Hardison, Ross C., Weiss, Mitchell J., Blobel, Gerd A.
Publicado 2022