Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes

por Schmid, Christina, Abi-Gerges, Najah, Leitner, Michael Georg, Zellner, Dietmar, Rast, Georg
Publicado 2021

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual...

por Britton, Oliver J., Abi-Gerges, Najah, Page, Guy, Ghetti, Andre, Miller, Paul E., Rodriguez, Blanca
Publicado 2017

Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

por Qu, Yusheng, Page, Guy, Abi-Gerges, Najah, Miller, Paul E., Ghetti, Andre, Vargas, Hugo M.
Publicado 2018

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities

por Trovato, Cristian, Passini, Elisa, Nagy, Norbert, Varró, András, Abi-Gerges, Najah, Severi, Stefano, Rodriguez, Blanca
Publicado 2020

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

por Nguyen, Nathalie, Nguyen, William, Nguyenton, Brynna, Ratchada, Phachareeya, Page, Guy, Miller, Paul E., Ghetti, Andre, Abi-Gerges, Najah
Publicado 2017

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

por Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.
Publicado 2013

Multiparametric Mechanistic Profiling of Inotropic Drugs in Adult Human Primary Cardiomyocytes

por Abi-Gerges, Najah, Indersmitten, Tim, Truong, Ky, Nguyen, William, Ratchada, Phachareeya, Nguyen, Nathalie, Page, Guy, Miller, Paul E., Ghetti, Andre
Publicado 2020

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

por Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah
Publicado 2014

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

por Hill, Adam P., Perry, Matthew D., Abi‐Gerges, Najah, Couderc, Jean‐Philippe, Fermini, Bernard, Hancox, Jules C., Knollmann, Bjorn C., Mirams, Gary R., Skinner, Jon, Zareba, Wojciech, Vandenberg, Jamie I.
Publicado 2016

Interventricular Differences in β‐Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases

por Molina, Cristina E., Johnson, Daniel M., Mehel, Hind, Spätjens, Roel L. H. M. G., Mika, Delphine, Algalarrondo, Vincent, Slimane, Zeineb Haj, Lechêne, Patrick, Abi‐Gerges, Najah, van der Linde, Henk J., Leroy, Jérôme, Volders, Paul G. A., Fischmeister, Rodolphe, Vandecasteele, Grégoire
Publicado 2014

Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart

por Ton, Anh Tuan, Nguyen, William, Sweat, Katrina, Miron, Yannick, Hernandez, Eduardo, Wong, Tiara, Geft, Valentyna, Macias, Andrew, Espinoza, Ana, Truong, Ky, Rasoul, Lana, Stafford, Alexa, Cotta, Tamara, Mai, Christina, Indersmitten, Tim, Page, Guy, Miller, Paul E., Ghetti, Andre, Abi-Gerges, Najah
Publicado 2021

Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells

por Dark, Nicola, Cosson, Marie-Victoire, Tsansizi, Lorenza I., Owen, Thomas J., Ferraro, Elisa, Francis, Alice J., Tsai, Selina, Bouissou, Camille, Weston, Anne, Collinson, Lucy, Abi-Gerges, Najah, Miller, Paul E., MacLeod, Kenneth T., Ehler, Elisabeth, Mitter, Richard, Harding, Sian E., Smith, James C., Bernardo, Andreia S.
Publicado 2023

Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity

por Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy.
Publicado 2020

Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo

por Miller, Jessica M., Meki, Moustafa H., Elnakib, Ahmed, Ou, Qinghui, Abouleisa, Riham R. E., Tang, Xian-Liang, Salama, Abou Bakr M., Gebreil, Ahmad, Lin, Cindy, Abdeltawab, Hisham, Khalifa, Fahmi, Hill, Bradford G., Abi-Gerges, Najah, Bolli, Roberto, El-Baz, Ayman S., Giridharan, Guruprasad A., Mohamed, Tamer M. A.
Publicado 2022

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

por Rodriguez, Blanca, Carusi, Annamaria, Abi-Gerges, Najah, Ariga, Rina, Britton, Oliver, Bub, Gil, Bueno-Orovio, Alfonso, Burton, Rebecca A.B., Carapella, Valentina, Cardone-Noott, Louie, Daniels, Matthew J., Davies, Mark R., Dutta, Sara, Ghetti, Andre, Grau, Vicente, Harmer, Stephen, Kopljar, Ivan, Lambiase, Pier, Lu, Hua Rong, Lyon, Aurore, Minchole, Ana, Muszkiewicz, Anna, Oster, Julien, Paci, Michelangelo, Passini, Elisa, Severi, Stefano, Taggart, Peter, Tinker, Andy, Valentin, Jean-Pierre, Varro, Andras, Wallman, Mikael, Zhou, Xin
Publicado 2016