Dynamic regulation of epigenomic landscapes during hematopoiesis

por Abraham, Brian J, Cui, Kairong, Tang, Qingsong, Zhao, Keji
Publicado 2013

Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights

por Shendy, Noha A.M., Zimmerman, Mark W., Abraham, Brian J., Durbin, Adam D.
Publicado 2022

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

por Shi, Hui, Tao, Ting, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Kadoch, Cigall, Look, A. Thomas
Publicado 2020

Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements

por Dowen, Jill M., Bilodeau, Steve, Orlando, David A., Hübner, Michael R., Abraham, Brian J., Spector, David L., Young, Richard A.
Publicado 2013

Models of human core transcriptional regulatory circuitries

por Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Reddy, Jessica, Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Publicado 2016

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

por Gao, Yang, Volegova, Marina, Nasholm, Nicole, Das, Sanjukta, Kwiatkowski, Nicholas, Abraham, Brian J., Zhang, Tinghu, Gray, Nathanael S., Gustafson, Clay, Krajewska, Malgorzata, George, Rani E.
Publicado 2022

Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression

por Soldner, Frank, Stelzer, Yonatan, Shivalila, Chikdu S., Abraham, Brian J., Latourelle, Jeanne C., Barrasa, M. Inmaculada, Goldmann, Johanna, Myers, Richard H., Young, Richard A., Jaenisch, Rudolf
Publicado 2016

Regulatory architecture of housekeeping genes is driven by promoter assemblies

por Dejosez, Marion, Dall’Agnese, Alessandra, Ramamoorthy, Mahesh, Platt, Jesse, Yin, Xing, Hogan, Megan, Brosh, Ran, Weintraub, Abraham S., Hnisz, Denes, Abraham, Brian J., Young, Richard A., Zwaka, Thomas P.
Publicado 2023

Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

por Zimmerman, Mark W., Durbin, Adam D., He, Shuning, Oppel, Felix, Shi, Hui, Tao, Ting, Li, Zhaodong, Berezovskaya, Alla, Liu, Yu, Zhang, Jinghui, Young, Richard A., Abraham, Brian J., Look, A. Thomas
Publicado 2021

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

por Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas
Publicado 2020

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

por Weichert-Leahey, Nina, Shi, Hui, Tao, Ting, Oldridge, Derek A., Durbin, Adam D., Abraham, Brian J., Zimmerman, Mark W., Zhu, Shizhen, Wood, Andrew C., Reyon, Deepak, Joung, J. Keith, Young, Richard A., Diskin, Sharon J., Maris, John M., Look, A. Thomas
Publicado 2023

Small genomic insertions form enhancers that misregulate oncogenes

por Abraham, Brian J., Hnisz, Denes, Weintraub, Abraham S., Kwiatkowski, Nicholas, Li, Charles H., Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Lee, Tong Ihn, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Young, Richard A.
Publicado 2017

Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes

por Abraham, Brian J., Hnisz, Denes, Weintraub, Abraham S., Kwiatkowski, Nicholas, Li, Charles H., Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Lee, Tong Ihn, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Young, Richard A.
Publicado 2017

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

por Wang, Lu, Tan, Tze King, Durbin, Adam D., Zimmerman, Mark W., Abraham, Brian J., Tan, Shi Hao, Ngoc, Phuong Cao Thi, Weichert-Leahey, Nina, Akahane, Koshi, Lawton, Lee N., Rokita, Jo Lynne, Maris, John M., Young, Richard A., Look, A. Thomas, Sanda, Takaomi
Publicado 2019

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

por Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly
Publicado 2018

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

por Betancur, Paola A., Abraham, Brian J., Yiu, Ying Y., Willingham, Stephen B., Khameneh, Farnaz, Zarnegar, Mark, Kuo, Angera H., McKenna, Kelly, Kojima, Yoko, Leeper, Nicholas J., Ho, Po, Gip, Phung, Swigut, Tomek, Sherwood, Richard I., Clarke, Michael F., Somlo, George, Young, Richard A., Weissman, Irving L.
Publicado 2017

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

por Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A., Henriques, Telmo, Dorjsuren, Bilguujin, Greig, Eugenia Custo, McCall, Wyatt, Stanhope, Meredith E., Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J., Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I.
Publicado 2020

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

por De Wyn, Jolien, Zimmerman, Mark W., Weichert-Leahey, Nina, Nunes, Carolina, Cheung, Belamy B., Abraham, Brian J., Beckers, Anneleen, Volders, Pieter-Jan, Decaesteker, Bieke, Carter, Daniel R., Look, Alfred Thomas, De Preter, Katleen, Van Loocke, Wouter, Marshall, Glenn M., Durbin, Adam D., Speleman, Frank, Durinck, Kaat
Publicado 2021

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

por Searcy, Madeline B., Larsen, Randolph K., Stevens, Bradley T., Zhang, Yang, Jin, Hongjian, Drummond, Catherine J., Langdon, Casey G., Gadek, Katherine E., Vuong, Kyna, Reed, Kristin B., Garcia, Matthew R., Xu, Beisi, Kimbrough, Darden W., Adkins, Grace E., Djekidel, Nadhir, Porter, Shaina N., Schreiner, Patrick A., Pruett-Miller, Shondra M., Abraham, Brian J., Rehg, Jerold E., Hatley, Mark E.
Publicado 2023

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

por Guo, Yang Eric, Manteiga, John C., Henninger, Jonathan E., Sabari, Benjamin R., Dall’Agnese, Alessandra, Hannett, Nancy M., Spille, Jan-Hendrik, Afeyan, Lena K., Zamudio, Alicia V., Shrinivas, Krishna, Abraham, Brian J., Boija, Ann, Decker, Tim-Michael, Rimel, Jenna K., Fant, Charli B., Lee, Tong Ihn, Cisse, Ibrahim I., Sharp, Phillip A., Taatjes, Dylan J., Young, Richard A.
Publicado 2019