Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

por ABRAHAMS, KATHERINE A., BESRA, GURDYAL S.
Publicado 2018

Synthesis and recycling of the mycobacterial cell envelope

por Abrahams, Katherine A, Besra, Gurdyal S
Publicado 2021

Mycobacterial drug discovery

por Abrahams, Katherine A., Besra, Gurdyal S.
Publicado 2020

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

por Abrahams, Katherine A., Batt, Sarah M., Gurcha, Sudagar S., Veerapen, Natacha, Bashiri, Ghader, Besra, Gurdyal S.
Publicado 2023

Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

por Dow, Mark, Marchetti, Francesco, Abrahams, Katherine A., Vaz, Luis, Besra, Gurdyal S., Warriner, Stuart, Nelson, Adam
Publicado 2017

Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

por Burke, Christopher, Abrahams, Katherine A., Richardson, Emily J., Loman, Nicholas J., Alemparte, Carlos, Lelievre, Joel, Besra, Gurdyal S.
Publicado 2019

Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

por Abrahams, Katherine A., Hu, Wei, Li, Gang, Lu, Yu, Richardson, Emily J., Loman, Nicholas J., Huang, Haihong, Besra, Gurdyal S.
Publicado 2020

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis

por Batt, Sarah M., Toth, Szilvi, Rodriguez, Beatriz, Abrahams, Katherine A., Veerapen, Natacha, Chiodarelli, Giacomo, Cox, Liam R., Moynihan, Patrick J., Lelievre, Joel, Fütterer, Klaus, Besra, Gurdyal S.
Publicado 2023

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

por Mugumbate, Grace, Abrahams, Katherine A., Cox, Jonathan A. G., Papadatos, George, van Westen, Gerard, Lelièvre, Joël, Calus, Szymon T., Loman, Nicholas J., Ballell, Lluis, Barros, David, Overington, John P., Besra, Gurdyal S.
Publicado 2015

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

por Grover, Shipra, Engelhart, Curtis A., Pérez-Herrán, Esther, Li, Wei, Abrahams, Katherine A., Papavinasasundaram, Kadamba, Bean, James M., Sassetti, Christopher M., Mendoza-Losana, Alfonso, Besra, Gurdyal S., Jackson, Mary, Schnappinger, Dirk
Publicado 2020

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

por Abrahams, Katherine A., Cox, Jonathan A. G., Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Fernández, Raquel, Alemparte, Carlos, Remuiñán, Modesto J., Barros, David, Ballell, Lluis, Besra, Gurdyal S.
Publicado 2012

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

por Abrahams, Katherine A., Cox, Jonathan A. G., Fütterer, Klaus, Rullas, Joaquín, Ortega-Muro, Fátima, Loman, Nicholas J., Moynihan, Patrick J., Pérez-Herrán, Esther, Jiménez, Elena, Esquivias, Jorge, Barros, David, Ballell, Lluís, Alemparte, Carlos, Besra, Gurdyal S.
Publicado 2017

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

por Cox, Jonathan A. G., Mugumbate, Grace, Del Peral, Laura Vela-Glez, Jankute, Monika, Abrahams, Katherine A., Jervis, Peter, Jackenkroll, Stefan, Perez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramon, Fernando, Barros, David, Ballell, Lluis, Besra, Gurdyal S.
Publicado 2016

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

por Gurcha, Sudagar S., Usha, Veeraraghavan, Cox, Jonathan A. G., Fütterer, Klaus, Abrahams, Katherine A., Bhatt, Apoorva, Alderwick, Luke J., Reynolds, Robert C., Loman, Nicholas J., Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J., Ballell, Lluis, Hobrath, Judith V., Besra, Gurdyal S.
Publicado 2014

Identification of KasA as the cellular target of an anti-tubercular scaffold

por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado 2016