Introduction of a 6-cyano group in 14-oxygenated N-methylmorphinans influences in vitro and in vivo pharmacological activities

por Follia, Valeria, Aceto, Mario D, Harris, Louis S, Coop, Andrew, Schmidhammer, Helmut, Spetea, Mariana
Publicado 2011

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

por Aceto, Mario D., Harris, Louis S., Negus, S. Stevens, Banks, Matthew L., Hughes, Larry D., Akgün, Eyup, Portoghese, Philip S.
Publicado 2012

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

por Ben Haddou, Tanila, Malfacini, Davide, Calo, Girolamo, Aceto, Mario D, Harris, Louis S, Traynor, John R, Coop, Andrew, Schmidhammer, Helmut, Spetea, Mariana
Publicado 2014

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity

por Greedy, Benjamin M., Bradbury, Faye, Thomas, Mark P., Grivas, Konstantinos, Cami-Kobeci, Gerta, Archambeau, Ashley, Bosse, Kelly, Clark, Mary J., Aceto, Mario, Lewis, John W., Traynor, John R., Husbands, Stephen M.
Publicado 2013

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects

por Moynihan, Humphrey A., Derrick, Ian., Broadbear, Jillian H., Greedy, Benjamin M., Aceto, Mario D., Harris, Louis S., Purington, Lauren C. S., Thomas, Mark P., Woods, James H., Traynor, John R., Husbands, Stephen M., Lewis, John W.
Publicado 2012