A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules

por Patel-Murray, Natasha L., Adam, Miriam, Huynh, Nhan, Wassie, Brook T., Milani, Pamela, Fraenkel, Ernest
Publicado 2020

Non-invasive assessment of normal and impaired iron homeostasis in the brain

por Filo, Shir, Shaharabani, Rona, Bar Hanin, Daniel, Adam, Miriam, Ben-David, Eliel, Schoffman, Hanan, Margalit, Nevo, Habib, Naomi, Shahar, Tal, Mezer, Aviv A.
Publicado 2023

Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells

por Milani, Pamela, Escalante-Chong, Renan, Shelley, Brandon C., Patel-Murray, Natasha L., Xin, Xiaofeng, Adam, Miriam, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N., Fraenkel, Ernest
Publicado 2016

Early sample tagging and pooling enables simultaneous SARS-CoV-2 detection and variant sequencing

por Chappleboim, Alon, Joseph-Strauss, Daphna, Rahat, Ayelet, Sharkia, Israa, Adam, Miriam, Kitsberg, Daniel, Fialkoff, Gavriel, Lotem, Matan, Gershon, Omer, Schmidtner, Anna-Kristina, Oiknine-Djian, Esther, Klochendler, Agnes, Sadeh, Ronen, Dor, Yuval, Wolf, Dana, Habib, Naomi, Friedman, Nir
Publicado 2021

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

por Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest, Thompson, Leslie M.
Publicado 2020

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model

por Suzzi, Stefano, Croese, Tommaso, Ravid, Adi, Gold, Or, Clark, Abbe R., Medina, Sedi, Kitsberg, Daniel, Adam, Miriam, Vernon, Katherine A., Kohnert, Eva, Shapira, Inbar, Malitsky, Sergey, Itkin, Maxim, Brandis, Alexander, Mehlman, Tevie, Salame, Tomer M., Colaiuta, Sarah P., Cahalon, Liora, Slyper, Michal, Greka, Anna, Habib, Naomi, Schwartz, Michal
Publicado 2023

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

por Lim, Ryan G., Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P., Reidling, Jack C., Tang, Guomei, Adam, Miriam, Dansu, David K., Park, Hye-Jin, Casaccia, Patrizia, Miramontes, Ricardo, Reyes-Ortiz, Andrea M., Lau, Alice, Hickman, Richard A., Khan, Fatima, Paryani, Fahad, Tang, Alice, Ofori, Kenneth, Miyoshi, Emily, Michael, Neethu, McClure, Nicolette, Flowers, Xena E., Vonsattel, Jean Paul, Davidson, Shawn, Menon, Vilas, Swarup, Vivek, Fraenkel, Ernest, Goldman, James E., Thompson, Leslie M.
Publicado 2022

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

por Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Fraenkel, Ernest, Rothstein, Jeffrey D., Sareen, Dhruv, Svendsen, Clive N., Thompson, Leslie M.
Publicado 2021

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

por Gross, Sean M., Dane, Mark A., Smith, Rebecca L., Devlin, Kaylyn L., McLean, Ian C., Derrick, Daniel S., Mills, Caitlin E., Subramanian, Kartik, London, Alexandra B., Torre, Denis, Evangelista, John Erol, Clarke, Daniel J. B., Xie, Zhuorui, Erdem, Cemal, Lyons, Nicholas, Natoli, Ted, Pessa, Sarah, Lu, Xiaodong, Mullahoo, James, Li, Jonathan, Adam, Miriam, Wassie, Brook, Liu, Moqing, Kilburn, David F., Liby, Tiera A., Bucher, Elmar, Sanchez-Aguila, Crystal, Daily, Kenneth, Omberg, Larsson, Wang, Yunguan, Jacobson, Connor, Yapp, Clarence, Chung, Mirra, Vidovic, Dusica, Lu, Yiling, Schurer, Stephan, Lee, Albert, Pillai, Ajay, Subramanian, Aravind, Papanastasiou, Malvina, Fraenkel, Ernest, Feiler, Heidi S., Mills, Gordon B., Jaffe, Jake D., Ma’ayan, Avi, Birtwistle, Marc R., Sorger, Peter K., Korkola, James E., Gray, Joe W., Heiser, Laura M.
Publicado 2022

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

por Baxi, Emily G., Thompson, Terri, Li, Jonathan, Kaye, Julia A., Lim, Ryan G., Wu, Jie, Ramamoorthy, Divya, Lima, Leandro, Vaibhav, Vineet, Matlock, Andrea, Frank, Aaron, Coyne, Alyssa N., Landin, Barry, Ornelas, Loren, Mosmiller, Elizabeth, Thrower, Sara, Farr, S. Michelle, Panther, Lindsey, Gomez, Emilda, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Mandefro, Berhan, Trost, Hannah, Pinedo, Louis, Banuelos, Maria G., Liu, Chunyan, Moran, Ruby, Garcia, Veronica, Workman, Michael, Ho, Richie, Wyman, Stacia, Roggenbuck, Jennifer, Harms, Matthew B., Stocksdale, Jennifer, Miramontes, Ricardo, Wang, Keona, Venkatraman, Vidya, Holewenski, Ronald, Sundararaman, Niveda, Pandey, Rakhi, Manalo, Danica-Mae, Donde, Aneesh, Huynh, Nhan, Adam, Miriam, Wassie, Brook T., Vertudes, Edward, Amirani, Naufa, Raja, Krishna, Thomas, Reuben, Hayes, Lindsey, Lenail, Alex, Cerezo, Aianna, Luppino, Sarah, Farrar, Alanna, Pothier, Lindsay, Prina, Carolyn, Morgan, Todd, Jamil, Arish, Heintzman, Sarah, Jockel-Balsarotti, Jennifer, Karanja, Elizabeth, Markway, Jesse, McCallum, Molly, Joslin, Ben, Alibazoglu, Deniz, Kolb, Stephen, Ajroud-Driss, Senda, Baloh, Robert, Heitzman, Daragh, Miller, Tim, Glass, Jonathan D., Patel-Murray, Natasha Leanna, Yu, Hong, Sinani, Ervin, Vigneswaran, Prasha, Sherman, Alexander V., Ahmad, Omar, Roy, Promit, Beavers, Jay C., Zeiler, Steven, Krakauer, John W., Agurto, Carla, Cecchi, Guillermo, Bellard, Mary, Raghav, Yogindra, Sachs, Karen, Ehrenberger, Tobias, Bruce, Elizabeth, Cudkowicz, Merit E., Maragakis, Nicholas, Norel, Raquel, Van Eyk, Jennifer E., Finkbeiner, Steven, Berry, James, Sareen, Dhruv, Thompson, Leslie M., Fraenkel, Ernest, Svendsen, Clive N., Rothstein, Jeffrey D.
Publicado 2022