Rattus norvegicus BN/SHR liver and heart left ventricle ribosomal RNA depleted directional RNA sequencing

por Wyler, Emanuel, van Heesch, Sebastiaan, Adami, Eleonora, Hubner, Norbert, Landthaler, Markus
Publicado 2017

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player

por Corden, Benjamin, Adami, Eleonora, Sweeney, Mark, Schafer, Sebastian, Cook, Stuart A.
Publicado 2020

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

por Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Schafer, Sebastian, Kuthubudeen, Fathima F, Widjaja, Anissa A, Cook, Stuart A
Publicado 2021

deltaTE: Detection of Translationally Regulated Genes by Integrative Analysis of Ribo‐seq and RNA‐seq Data

por Chothani, Sonia, Adami, Eleonora, Ouyang, John F., Viswanathan, Sivakumar, Hubner, Norbert, Cook, Stuart A., Schafer, Sebastian, Rackham, Owen J. L.
Publicado 2019

Translational regulation shapes the molecular landscape of complex disease phenotypes

por Schafer, Sebastian, Adami, Eleonora, Heinig, Matthias, Rodrigues, Katharina E. Costa, Kreuchwig, Franziska, Silhavy, Jan, van Heesch, Sebastiaan, Simaite, Deimante, Rajewsky, Nikolaus, Cuppen, Edwin, Pravenec, Michal, Vingron, Martin, Cook, Stuart A., Hubner, Norbert
Publicado 2015

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

por Widjaja, Anissa A., Viswanathan, Sivakumar, Jinrui, Dong, Singh, Brijesh K., Tan, Jessie, Wei Ting, Joyce Goh, Lamb, David, Shekeran, Shamini G., George, Benjamin L., Schafer, Sebastian, Carling, David, Adami, Eleonora, Cook, Stuart A.
Publicado 2021

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

por Ng, Benjamin, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Shekeran, Shamini G., Goh, Joyce Wei Ting, Tan, Jessie, Kuthubudeen, Fathima, Lim, Sze Yun, Xie, Chen, Schafer, Sebastian, Adami, Eleonora, Cook, Stuart A.
Publicado 2022

Genomic landscape of rat strain and substrain variation

por Hermsen, Roel, de Ligt, Joep, Spee, Wim, Blokzijl, Francis, Schäfer, Sebastian, Adami, Eleonora, Boymans, Sander, Flink, Stephen, van Boxtel, Ruben, van der Weide, Robin H, Aitman, Tim, Hübner, Norbert, Simonis, Marieke, Tabakoff, Boris, Guryev, Victor, Cuppen, Edwin
Publicado 2015

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function

por McDermott-Roe, Chris, Leleu, Marion, Rowe, Glenn C., Palygin, Oleg, Bukowy, John D., Kuo, Judy, Rech, Monika, Hermans-Beijnsberger, Steffie, Schaefer, Sebastian, Adami, Eleonora, Creemers, Esther E., Heinig, Matthias, Schroen, Blanche, Arany, Zoltan, Petretto, Enrico, Geurts, Aron M.
Publicado 2017

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts

por Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A, Ng, Benjamin, Chothani, Sonia, Zhihao, Nevin, Tan, Jessie, Lio, Pei Min, George, Benjamin L, Altunoglu, Umut, Ghosh, Kakaly, Paleja, Bhairav S, Schafer, Sebastian, Reversade, Bruno, Albani, Salvatore, Ling, Andrea Low Hsiu, O'Reilly, Steven, Cook, Stuart A
Publicado 2021

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

por Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan
Publicado 2021

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

por Widjaja, Anissa A., Viswanathan, Sivakumar, Shekeran, Shamini G., Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M., Hawkins, Julie, Petretto, Enrico, Hübner, Norbert, Schafer, Sebastian, Coffman, Thomas M., Cook, Stuart A.
Publicado 2022

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

por Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K., Chothani, Sonia P., Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole S. J., Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Publicado 2021

Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism

por Loos, Malte, Klampe, Birgit, Schulze, Thomas, Yin, Xiaoke, Theofilatos, Konstantinos, Ulmer, Bärbel Maria, Schulz, Carl, Behrens, Charlotta S., van Bergen, Tessa Diana, Adami, Eleonora, Maatz, Henrike, Schweizer, Michaela, Brodesser, Susanne, Skryabin, Boris V., Rozhdestvensky, Timofey S., Bodbin, Sara, Stathopoulou, Konstantina, Christ, Torsten, Denning, Chris, Hübner, Norbert, Mayr, Manuel, Cuello, Friederike, Eschenhagen, Thomas, Hansen, Arne
Publicado 2023

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

por Sandmann, Clara-L., Schulz, Jana F., Ruiz-Orera, Jorge, Kirchner, Marieluise, Ziehm, Matthias, Adami, Eleonora, Marczenke, Maike, Christ, Annabel, Liebe, Nina, Greiner, Johannes, Schoenenberger, Aaron, Muecke, Michael B., Liang, Ning, Moritz, Robert L., Sun, Zhi, Deutsch, Eric W., Gotthardt, Michael, Mudge, Jonathan M., Prensner, John R., Willnow, Thomas E., Mertins, Philipp, van Heesch, Sebastiaan, Hubner, Norbert
Publicado 2023

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

por Chothani, Sonia, Schäfer, Sebastian, Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A., Langley, Sarah R., Tan, Jessie, Wang, Mao, Quaife, Nicholas M., Jian Pua, Chee, D’Agostino, Giuseppe, Guna Shekeran, Shamini, George, Benjamin L., Lim, Stella, Yiqun Cao, Elaine, van Heesch, Sebastiaan, Witte, Franziska, Felkin, Leanne E., Christodoulou, Eleni G., Dong, Jinrui, Blachut, Susanne, Patone, Giannino, Barton, Paul J.R., Hubner, Norbert, Cook, Stuart A., Rackham, Owen J.L.
Publicado 2019

Titin truncating variants affect heart function in disease cohorts and the general population

por Schafer, Sebastian, de Marvao, Antonio, Adami, Eleonora, Fiedler, Lorna R, Ng, Benjamin, Khin, Ester, Rackham, Owen J L, van Heesch, Sebastiaan, Pua, Chee J, Kui, Miao, Walsh, Roddy, Tayal, Upasana, Prasad, Sanjay K, Dawes, Timothy J W, Ko, Nicole S J, Sim, David, Chan, Laura L, Chin, Calvin W L, Mazzarotto, Francesco, Barton, Paul J, Kreuchwig, Franziska, de Kleijn, Dominique P V, Totman, Teresa, Biffi, Carlo, Tee, Nicole, Rueckert, Daniel, Schneider, Valentin, Faber, Allison, Regitz-Zagrosek, Vera, Seidman, Jonathan G, Seidman, Christine E, Linke, Wolfgang A, Kovalik, Jean-Paul, O’Regan, Declan Patrick, Ware, James S, Hubner, Norbert, Cook, Stuart A
Publicado 2016

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

por Reichart, Daniel, Lindberg, Eric L., Maatz, Henrike, Miranda, Antonio M.A., Viveiros, Anissa, Shvetsov, Nikolay, Gärtner, Anna, Nadelmann, Emily R., Lee, Michael, Kanemaru, Kazumasa, Ruiz-Orera, Jorge, Strohmenger, Viktoria, DeLaughter, Daniel M., Patone, Giannino, Zhang, Hao, Woehler, Andrew, Lippert, Christoph, Kim, Yuri, Adami, Eleonora, Gorham, Joshua M., Barnett, Sam N., Brown, Kemar, Buchan, Rachel J., Chowdhury, Rasheda A., Constantinou, Chrystalla, Cranley, James, Felkin, Leanne E., Fox, Henrik, Ghauri, Ahla, Gummert, Jan, Kanda, Masatoshi, Li, Ruoyan, Mach, Lukas, McDonough, Barbara, Samari, Sara, Shahriaran, Farnoush, Yapp, Clarence, Stanasiuk, Caroline, Theotokis, Pantazis I., Theis, Fabian J., van den Bogaerdt, Antoon, Wakimoto, Hiroko, Ware, James S., Worth, Catherine L., Barton, Paul J.R., Lee, Young-Ae, Teichmann, Sarah A., Milting, Hendrik, Noseda, Michela, Oudit, Gavin Y., Heinig, Matthias, Seidman, Jonathan G., Hubner, Norbert, Seidman, Christine E.
Publicado 2022