The BCL-2 arbiters of apoptosis and their growing role as cancer targets

por Adams, Jerry M, Cory, Suzanne
Publicado 2018

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

por Tailler, Maximilien, Lindqvist, Lisa M., Gibson, Leonie, Adams, Jerry M.
Publicado 2018

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

por Naik, Edwina, Michalak, Ewa M., Villunger, Andreas, Adams, Jerry M., Strasser, Andreas
Publicado 2007

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

por Marsden, Vanessa S., Ekert, Paul G., Van Delft, Mark, Vaux, David L., Adams, Jerry M., Strasser, Andreas
Publicado 2004

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

por Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., Kluck, Ruth M.
Publicado 2007

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-X(L)

por Hausmann, George, O'Reilly, Lorraine A., van Driel, Rosemary, Beaumont, Jennifer G., Strasser, Andreas, Adams, Jerry M., Huang, David C.S.
Publicado 2000

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

por Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.
Publicado 2020

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

por Naik, Edwina, O'Reilly, Lorraine A., Asselin-Labat, Marie-Liesse, Merino, Delphine, Lin, Ann, Cook, Michele, Coultas, Leigh, Bouillet, Philippe, Adams, Jerry M., Strasser, Andreas
Publicado 2011

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

por Mérino, Delphine, Giam, Maybelline, Hughes, Peter D., Siggs, Owen M., Heger, Klaus, O'Reilly, Lorraine A., Adams, Jerry M., Strasser, Andreas, Lee, Erinna F., Fairlie, Walter D., Bouillet, Philippe
Publicado 2009

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

por Wilson-Annan, Julie, O'Reilly, Lorraine A., Crawford, Simon A., Hausmann, George, Beaumont, Jennifer G., Parma, Loes P., Chen, Lin, Lackmann, Martin, Lithgow, Trevor, Hinds, Mark G., Day, Catherine L., Adams, Jerry M., Huang, David C.S.
Publicado 2003

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

por Moujalled, Donia M., Brown, Fiona C., Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.
Publicado 2023