Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence

por Tolksdorf, Beatrice, Nie, Chuanxiong, Niemeyer, Daniela, Röhrs, Viola, Berg, Johanna, Lauster, Daniel, Adler, Julia M., Haag, Rainer, Trimpert, Jakob, Kaufer, Benedikt, Drosten, Christian, Kurreck, Jens
Publicado 2021

A non-transmissible live attenuated SARS-CoV-2 vaccine

por Adler, Julia M., Martin Vidal, Ricardo, Voß, Anne, Kunder, Sandra, Nascimento, Mariana, Abdelgawad, Azza, Langner, Christine, Vladimirova, Daria, Osterrieder, Nikolaus, Gruber, Achim D., Kunec, Dusan, Trimpert, Jakob
Publicado 2023

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)

por Trimpert, Jakob, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Firsching, Theresa C., Ebert, Nadine, Thao, Tran Thi Nhu, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Publicado 2021

In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs(®) 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2

por Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M., Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D., Trimpert, Jakob, Müller, Marcel A.
Publicado 2023

Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines—A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters

por Trimpert, Jakob, Herwig, Susanne, Stein, Julia, Vladimirova, Daria, Adler, Julia M., Abdelgawad, Azza, Firsching, Theresa C., Thoma, Tizia, Sehouli, Jalid, Osterrieder, Klaus, Gruber, Achim D., Sawitzki, Birgit, Sander, Leif Erik, Cichon, Günter
Publicado 2021

Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration

por Abdelaziz, Mohammed O., Raftery, Martin J., Weihs, Julian, Bielawski, Olivia, Edel, Richard, Köppke, Julia, Vladimirova, Daria, Adler, Julia M., Firsching, Theresa, Voß, Anne, Gruber, Achim D., Hummel, Luca V., Fernandez Munoz, Ivan, Müller-Marquardt, Francesca, Willimsky, Gerald, Elleboudy, Nooran S., Trimpert, Jakob, Schönrich, Günther
Publicado 2023

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding

por Trimpert, Jakob, Dietert, Kristina, Firsching, Theresa C., Ebert, Nadine, Thi Nhu Thao, Tran, Vladimirova, Daria, Kaufer, Susanne, Labroussaa, Fabien, Abdelgawad, Azza, Conradie, Andelé, Höfler, Thomas, Adler, Julia M., Bertzbach, Luca D., Jores, Joerg, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Publicado 2021

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

por Wyler, Emanuel, Adler, Julia M., Eschke, Kathrin, Teixeira Alves, G., Peidli, Stefan, Pott, Fabian, Kazmierski, Julia, Michalick, Laura, Kershaw, Olivia, Bushe, Judith, Andreotti, Sandro, Pennitz, Peter, Abdelgawad, Azza, Postmus, Dylan, Goffinet, Christine, Kreye, Jakob, Reincke, S Momsen, Prüss, Harald, Blüthgen, Nils, Gruber, Achim D., Kuebler, Wolfgang M., Witzenrath, Martin, Landthaler, Markus, Nouailles, Geraldine, Trimpert, Jakob
Publicado 2022

Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron

por Kreye, Jakob, Reincke, S. Momsen, Edelburg, Stefan, Jeworowski, Lara M., Kornau, Hans-Christian, Trimpert, Jakob, Hombach, Peter, Halbe, Sophia, Nölle, Volker, Meyer, Martin, Kattenbach, Stefanie, Sánchez-Sendin, Elisa, Schmidt, Marie L., Schwarz, Tatjana, Rose, Ruben, Krumbholz, Andi, Merz, Sophie, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Schmitz, Dietmar, Sander, Leif E., Janssen, Uwe, Corman, Victor M., Prüss, Harald
Publicado 2023

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

por Shytaj, Iart Luca, Fares, Mohamed, Gallucci, Lara, Lucic, Bojana, Tolba, Mahmoud M., Zimmermann, Liv, Adler, Julia M., Xing, Na, Bushe, Judith, Gruber, Achim D., Ambiel, Ina, Taha Ayoub, Ahmed, Cortese, Mirko, Neufeldt, Christopher J., Stolp, Bettina, Sobhy, Mohamed Hossam, Fathy, Moustafa, Zhao, Min, Laketa, Vibor, Diaz, Ricardo Sobhie, Sutton, Richard E., Chlanda, Petr, Boulant, Steeve, Bartenschlager, Ralf, Stanifer, Megan L., Fackler, Oliver T., Trimpert, Jakob, Savarino, Andrea, Lusic, Marina
Publicado 2022

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

por Nouailles, Geraldine, Adler, Julia M., Pennitz, Peter, Peidli, Stefan, Teixeira Alves, Luiz Gustavo, Baumgardt, Morris, Bushe, Judith, Voss, Anne, Langenhagen, Alina, Langner, Christine, Martin Vidal, Ricardo, Pott, Fabian, Kazmierski, Julia, Ebenig, Aileen, Lange, Mona V., Mühlebach, Michael D., Goekeri, Cengiz, Simmons, Szandor, Xing, Na, Abdelgawad, Azza, Herwig, Susanne, Cichon, Günter, Niemeyer, Daniela, Drosten, Christian, Goffinet, Christine, Landthaler, Markus, Blüthgen, Nils, Wu, Haibo, Witzenrath, Martin, Gruber, Achim D., Praktiknjo, Samantha D., Osterrieder, Nikolaus, Wyler, Emanuel, Kunec, Dusan, Trimpert, Jakob
Publicado 2023

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

por Rothenberger, Sylvia, Hurdiss, Daniel L., Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H. Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M., Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D., Bushe, Judith, Kershaw, Olivia, Knutson, Charles G., Balavenkatraman, Kamal K., Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A., Zürcher, Alexander, Dawson, Keith M., Steiner, Daniel, Weiss, Carol D., Amstutz, Patrick, van Kuppeveld, Frank J. M., Stumpp, Michael T., Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob
Publicado 2022