Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

por Hauser, Stefan, Schuster, Stefanie, Heuten, Elena, Höflinger, Philip, Admard, Jakob, Schelling, Yvonne, Velic, Ana, Macek, Boris, Ossowski, Stephan, Schöls, Ludger
Publicado 2020

Enriched Environmental Conditions Modify the Gut Microbiome Composition and Fecal Markers of Inflammation in Parkinson’s Disease

por Singh, Yogesh, El-Hadidi, Mohamed, Admard, Jakob, Wassouf, Zinah, Schulze-Hentrich, Julia M., Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Huson, Daniel, Riess, Olaf, Casadei, Nicolas
Publicado 2019

Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling

por Cardona Gloria, Yamel, Bernhart, Stephan H., Fillinger, Sven, Wolz, Olaf-Oliver, Dickhöfer, Sabine, Admard, Jakob, Ossowski, Stephan, Nahnsen, Sven, Siebert, Reiner, Weber, Alexander N. R.
Publicado 2021

Genome sequencing identifies complex structural MLH1 variant in unsolved Lynch syndrome

por Witt, Dennis, Faust, Ulrike, Strobl‐Wildemann, Gertrud, Sturm, Marc, Buchert, Rebecca, Zuleger, Theresia, Admard, Jakob, Casadei, Nicolas, Ossowski, Stephan, Haack, Tobias B., Rieß, Olaf, Schroeder, Christopher
Publicado 2023

Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34(+) HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin

por Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Antony, Justin S., Epting, Thomas, Heumos, Lukas, Baskaran, Praveen, Admard, Jakob, Casadei, Nicolas, Latifi, Ngadhnjim, Siegmund, Darina M., Kormann, Michael S. D., Handgretinger, Rupert, Mezger, Markus
Publicado 2020

Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats

por Habermeyer, Johanna, Boyken, Janina, Harrer, Julia, Canneva, Fabio, Ratz, Veronika, Moceri, Sandra, Admard, Jakob, Casadei, Nicolas, Jost, Gregor, Bäuerle, Tobias, Frenzel, Thomas, Schmitz, Christoph, Schütz, Gunnar, Pietsch, Hubertus, von Hörsten, Stephan
Publicado 2020

Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse

por Mittelstadt, Suzana, Kelemen, Olga, Admard, Jakob, Gschwind, Axel, Koch, André, Wörz, Sarah, Oberlechner, Ernst, Engler, Tobias, Bonzheim, Irina, Staebler, Annette, Weidner, Nicola, Stubenrauch, Frank, Iftner, Thomas, Riess, Olaf, Schroeder, Christopher, Kommoss, Stefan, Ossowski, Stephan
Publicado 2023

Lasting response by vertical inhibition with cetuximab and trametinib in KRAS‐mutated colorectal cancer patient‐derived xenografts

por Reissig, Timm M., Ladigan‐Badura, Swetlana, Steinberg, Anja, Maghnouj, Abdelouahid, Li, Ting, Verdoodt, Berlinda, Liffers, Sven T., Pohl, Michael, Wolters, Heiner, Teschendorf, Christian, Viebahn, Richard, Admard, Jakob, Casadei, Nicolas, Tannapfel, Andrea, Schmiegel, Wolff, Hahn, Stephan A., Vangala, Deepak B.
Publicado 2023

ATRT-19. Functional genomics reveal distinct modulators of response to CDK4/6 inhibitors in ATRTs

por Merk, Daniel, Hirsch, Sohpie, Tsiami, Foteini, Walter, Bianca, Haeusser, Lara, Babaei, Sepideh, Admard, Jakob, Casadei, Nicolas, Roggia, Cristiana, Spohn, Michael, Schittenhelm, Jens, Singer, Stephan, Schüller, Ulrich, Piccioni, Federica, Persky, Nicole, Root, David, Claassen, Manfred, Tatagiba, Marcos, Tabatabai, Ghazaleh
Publicado 2022

Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo

por Cheng, Fubo, Zheng, Wenxu, Liu, Chang, Barbuti, Peter Antony, Yu-Taeger, Libo, Casadei, Nicolas, Huebener-Schmid, Jeannette, Admard, Jakob, Boldt, Karsten, Junger, Katrin, Ueffing, Marius, Houlden, Henry, Sharma, Manu, Kruger, Rejko, Grundmann-Hauser, Kathrin, Ott, Thomas, Riess, Olaf
Publicado 2022

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

por Singh, Yogesh, Trautwein, Christoph, Romani, Joan, Salker, Madhuri S., Neckel, Peter H., Fraccaroli, Isabel, Abeditashi, Mahkameh, Woerner, Nils, Admard, Jakob, Dhariwal, Achal, Dueholm, Morten K. D., Schäfer, Karl-Herbert, Lang, Florian, Otzen, Daniel E., Lashuel, Hilal A., Riess, Olaf, Casadei, Nicolas
Publicado 2023

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)

por Singh, Yogesh, Trautwein, Christoph, Dhariwal, Achal, Salker, Madhuri S., Alauddin, Md, Zizmare, Laimdota, Pelzl, Lisann, Feger, Martina, Admard, Jakob, Casadei, Nicolas, Föller, Michael, Pachauri, Vivek, Park, David S., Mak, Tak W., Frick, Julia-Stefanie, Wallwiener, Diethelm, Brucker, Sara Y., Lang, Florian, Riess, Olaf
Publicado 2020

Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

por Bus, Christine, Zizmare, Laimdota, Feldkaemper, Marita, Geisler, Sven, Zarani, Maria, Schaedler, Anna, Klose, Franziska, Admard, Jakob, Mageean, Craig J., Arena, Giuseppe, Fallier-Becker, Petra, Ugun-Klusek, Aslihan, Maruszczak, Klaudia K., Kapolou, Konstantina, Schmid, Benjamin, Rapaport, Doron, Ueffing, Marius, Casadei, Nicolas, Krüger, Rejko, Gasser, Thomas, Vogt Weisenhorn, Daniela M., Kahle, Philipp J., Trautwein, Christoph, Gloeckner, Christian J., Fitzgerald, Julia C.
Publicado 2020

UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents

por Liebmann, Alexandra, Admard, Jakob, Armeanu-Ebinger, Sorin, Wild, Hannah, Abele, Michael, Gschwind, Axel, Seibel-Kelemen, Olga, Seitz, Christian, Bonzheim, Irina, Riess, Olaf, Demidov, German, Sturm, Marc, Schadeck, Malou, Pogoda, Michaela, Bien, Ewa, Krawczyk, Malgorzata, Jüttner, Eva, Mentzel, Thomas, Cesen, Maja, Pfaff, Elke, Kunc, Michal, Forchhammer, Stephan, Forschner, Andrea, Leiter-Stöppke, Ulrike, Eigentler, Thomas K., Schneider, Dominik T., Schroeder, Christopher, Ossowski, Stephan, Brecht, Ines B.
Publicado 2023

Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients

por Menzel, Michael, Ossowski, Stephan, Kral, Sebastian, Metzger, Patrick, Horak, Peter, Marienfeld, Ralf, Boerries, Melanie, Wolter, Steffen, Ball, Markus, Neumann, Olaf, Armeanu-Ebinger, Sorin, Schroeder, Christopher, Matysiak, Uta, Goldschmid, Hannah, Schipperges, Vincent, Fürstberger, Axel, Allgäuer, Michael, Eberhardt, Timo, Niewöhner, Jakob, Blaumeiser, Andreas, Ploeger, Carolin, Haack, Tobias Bernd, Tay, Timothy Kwang Yong, Kelemen, Olga, Pauli, Thomas, Kirchner, Martina, Kluck, Klaus, Ott, Alexander, Renner, Marcus, Admard, Jakob, Gschwind, Axel, Lassmann, Silke, Kestler, Hans, Fend, Falko, Illert, Anna Lena, Werner, Martin, Möller, Peter, Seufferlein, Thomas Theodor Werner, Malek, Nisar, Schirmacher, Peter, Fröhling, Stefan, Kazdal, Daniel, Budczies, Jan, Stenzinger, Albrecht
Publicado 2023

Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder

por Hengel, Holger, Hannan, Shabab B., Dyack, Sarah, MacKay, Sara B., Schatz, Ulrich, Fleger, Martin, Kurringer, Andreas, Balousha, Ghassan, Ghanim, Zaid, Alkuraya, Fowzan S., Alzaidan, Hamad, Alsaif, Hessa S., Mitani, Tadahiro, Bozdogan, Sevcan, Pehlivan, Davut, Lupski, James R., Gleeson, Joseph J., Dehghani, Mohammadreza, Mehrjardi, Mohammad Y.V., Sherr, Elliott H., Parks, Kendall C., Argilli, Emanuela, Begtrup, Amber, Galehdari, Hamid, Balousha, Osama, Shariati, Gholamreza, Mazaheri, Neda, Malamiri, Reza A., Pagnamenta, Alistair T., Kingston, Helen, Banka, Siddharth, Jackson, Adam, Osmond, Mathew, Rieß, Angelika, Haack, Tobias B., Nägele, Thomas, Schuster, Stefanie, Hauser, Stefan, Admard, Jakob, Casadei, Nicolas, Velic, Ana, Macek, Boris, Ossowski, Stephan, Houlden, Henry, Maroofian, Reza, Schöls, Ludger
Publicado 2021