Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?

por Boteon, Yuri L, Afford, Simon C
Publicado 2019

Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts

por Boteon, Yuri L., Afford, Simon C., Mergental, Hynek
Publicado 2018

Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

por Humphreys, Elizabeth H., Williams, Kevin T., Adams, David H., Afford, Simon C.
Publicado 2010

Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion

por Bhogal, Ricky H., Mirza, Darius F., Afford, Simon C., Mergental, Hynek
Publicado 2020

Reply to ‘Hypothermic machine perfusion before viability testing of previously discarded human livers’

por Mergental, Hynek, Laing, Richard W., Afford, Simon C., Mirza, Darius F.
Publicado 2021

C4b Binding Protein Binds to CD154 Preventing CD40 Mediated Cholangiocyte Apoptosis: A Novel Link between Complement and Epithelial Cell Survival

por Williams, Kevin T., Young, Steven P., Negus, Alison, Young, Lawrence S., Adams, David H., Afford, Simon C.
Publicado 2007

Activation of CD40 with Platelet Derived CD154 Promotes Reactive Oxygen Species Dependent Death of Human Hepatocytes during Hypoxia and Reoxygenation

por Bhogal, Ricky H., Weston, Christopher J., Curbishley, Stuart M., Adams, David H., Afford, Simon C.
Publicado 2012

CD40 Activation Induces Apoptosis in Cultured Human Hepatocytes via Induction of Cell Surface Fas Ligand Expression and Amplifies Fas-mediated Hepatocyte Death during Allograft Rej...

por Afford, Simon C., Randhawa, Satinder, Eliopoulos, Aristides G., Hubscher, Stefan G., Young, Lawrence S., Adams, David H.
Publicado 1999

Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review

por Boteon, Yuri L, Boteon, Amanda PCS, Attard, Joseph, Wallace, Lorraine, Bhogal, Ricky H, Afford, Simon C
Publicado 2018

How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury

por Clarke, George, Mergental, Hynek, Hann, Angus, Perera, M. Thamara P. R., Afford, Simon C., Mirza, Darius F.
Publicado 2021

Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H–R)

por Bhogal, Ricky H., Weston, Christopher J., Curbishley, Stuart M., Bhatt, Anand N., Adams, David H., Afford, Simon C.
Publicado 2011

Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion

por Boteon, Yuri L, Laing, Richard, Mergental, Hynek, Reynolds, Gary M, Mirza, Darius F, Afford, Simon C, Bhogal, Ricky H
Publicado 2017

Comment on Long-Term Normothermic Machine Preservation of Partial Livers: First Experience With 21 Human Hemilivers

por Mergental, Hynek, Stephenson, Barney T. F., Laing, Richard W., Muiesan, Paolo, Perera, M. Thamara P. R., Afford, Simon C., Mirza, Darius F.
Publicado 2022

Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery

por Boteon, Yuri L., Attard, Joseph, Boteon, Amanda P. C. S., Wallace, Lorraine, Reynolds, Gary, Hubscher, Stefan, Mirza, Darius F., Mergental, Hynek, Bhogal, Ricky H., Afford, Simon C.
Publicado 2019

Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection

por Brain, J G, Robertson, H, Thompson, E, Humphreys, E H, Gardner, A, Booth, T A, Jones, D E J, Afford, S C, von Zglinicki, T, Burt, A D, Kirby, J A
Publicado 2013

Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

por Wilhelm, Annika, Shepherd, Emma L, Amatucci, Aldo, Munir, Mamoona, Reynolds, Gary, Humphreys, Elizabeth, Resheq, Yazid, Adams, David H, Hübscher, Stefan, Burkly, Linda C, Weston, Christopher J, Afford, Simon C
Publicado 2016

Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience

por Bhogal, Ricky H., Hodson, James, Bartlett, David C., Weston, Christopher J., Curbishley, Stuart M., Haughton, Emma, Williams, Kevin T., Reynolds, Gary M., Newsome, Phillip N., Adams, David H., Afford, Simon C.
Publicado 2011

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions...

por Attard, Joseph A., Osei-Bordom, Daniel-Clement, Boteon, Yuri, Wallace, Lorraine, Ronca, Vincenzo, Reynolds, Gary, Perera, M. T. P. R., Oo, Ye Htun, Mergental, Hynek, Mirza, Darius F., Afford, Simon C.
Publicado 2021

Proof of concept: liver splitting during normothermic machine perfusion

por Stephenson, Barney T F, Bonney, Glenn K, Laing, Richard W, Bhogal, Ricky H, Marcon, Francesca, Neil, Desley A H, Perera, M Thamara P R, Afford, Simon C, Mergental, Hynek, Mirza, Darius F
Publicado 2018

The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-b...

por Boteon, Yuri L., Laing, Richard W., Schlegel, Andrea, Wallace, Lorraine, Smith, Amanda, Attard, Joseph, Bhogal, Ricky H., Reynolds, Gary, PR Perera, M. Thamara, Muiesan, Paolo, Mirza, Darius F., Mergental, Hynek, Afford, Simon C.
Publicado 2019