A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development

por O’Keefe, Ryan N., Carli, Annalisa L. E., Baloyan, David, Chisanga, David, Shi, Wei, Afshar-Sterle, Shoukat, Eissmann, Moritz F., Poh, Ashleigh R., Pal, Bhupinder, Seillet, Cyril, Locksley, Richard M., Ernst, Matthias, Buchert, Michael
Publicado 2023

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

por Thilakasiri, Pathum, Huynh, Jennifer, Poh, Ashleigh R, Tan, Chin Wee, Nero, Tracy L, Tran, Kelly, Parslow, Adam C, Afshar‐Sterle, Shoukat, Baloyan, David, Hannan, Natalie J, Buchert, Michael, Scott, Andrew Mark, Griffin, Michael DW, Hollande, Frederic, Parker, Michael W, Putoczki, Tracy L, Ernst, Matthias, Chand, Ashwini L
Publicado 2019

Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death

por Jenkins, Laura J., Luk, Ian Y., Fairlie, W. Douglas, Lee, Erinna F., Palmieri, Michelle, Schoffer, Kael L., Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson W.T., Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M., Dhillon, Amardeep S., Tebbutt, Niall C., Mariadason, John M.
Publicado 2023

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

por Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S., Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L., Westermann, Jürgen, Dempsey, Peter J., Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan
Publicado 2018

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

por Luk, Ian Y., Jenkins, Laura J., Schoffer, Kael L., Ng, Irvin, Tse, Janson W. T., Mouradov, Dmitri, Kaczmarczyk, Stanislaw, Nightingale, Rebecca, Burrows, Allan D., Anderson, Robin L., Arango, Diego, Dopeso, Higinio, Croft, Larry, Richardson, Mark F., Sieber, Oliver M., Liao, Yang, Mooi, Jennifer K., Vukelic, Natalia, Reehorst, Camilla M., Afshar-Sterle, Shoukat, Whitehall, Vicki L. J., Fennell, Lochlan, Abud, Helen E., Tebbutt, Niall C., Phillips, Wayne A., Williams, David S., Shi, Wei, Mielke, Lisa A., Ernst, Matthias, Dhillon, Amardeep S., Clemons, Nicholas J., Mariadason, John M.
Publicado 2022