Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells

por Kiselev, Evgeny, Sooryakumar, Dhriti, Agama, Keli, Cushman, Mark, Pommier, Yves
Publicado 2014

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors

por Lv, Peng-Cheng, Agama, Keli, Marchand, Christophe, Pommier, Yves, Cushman, Mark
Publicado 2014

Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

por Zhang, Hongliang, Seol, Yeonee, Agama, Keli, Neuman, Keir C., Pommier, Yves
Publicado 2017

Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

por Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Publicado 2011

Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indot...

por Beck, Daniel E., Agama, Keli, Marchand, Christophe, Chergui, Adel, Pommier, Yves, Cushman, Mark
Publicado 2014

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor

por Yu, Qian, Chen, Yu, Yang, Hui, Zhang, Hong-Li, Agama, Keli, Pommier, Yves, An, Lin-Kun
Publicado 2019

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica

por Ottaviani, Alessio, Welsch, Joshua, Agama, Keli, Pommier, Yves, Desideri, Alessandro, Baker, Bill J., Fiorani, Paola
Publicado 2022

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

por Zhang, Yong-Wei, Regairaz, Marie, Seiler, Jennifer A., Agama, Keli K., Doroshow, James H., Pommier, Yves
Publicado 2011

Alkyne Activation in the Diversity Oriented Synthesis of sp(2)‐Rich Scaffolds: A Biased Library Approach for Targeting Polynucleotides (DNA/RNA)

por Chen, Shuqi, Priebbenow, Daniel L., Somkhit, Julie, Scullino, Carmen V., Agama, Keli, Pommier, Yves, Flynn, Bernard L.
Publicado 2022

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as a...

por Antony, Smitha, Marchand, Christophe, Stephen, Andrew G., Thibaut, Laurent, Agama, Keli K., Fisher, Robert J., Pommier, Yves
Publicado 2007

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

por Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
Publicado 2011

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states

por Takahashi, Diane T., Gadelle, Danièle, Agama, Keli, Kiselev, Evgeny, Zhang, Hongliang, Yab, Emilie, Petrella, Stephanie, Forterre, Patrick, Pommier, Yves, Mayer, Claudine
Publicado 2022

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

por Sun, Yilun, Chen, Jiji, Huang, Shar-yin N., Su, Yijun P., Wang, Wenjie, Agama, Keli, Saha, Sourav, Jenkins, Lisa M., Pascal, John M., Pommier, Yves
Publicado 2021

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

por Saha, Sourav, Sun, Yilun, Naomi Huang, Shar-yin, Baechler, Simone Andrea, Pongor, Lorinc Sandor, Agama, Keli, Jo, Ukhyun, Zhang, Hongliang, Tse-Dinh, Yuk-Ching, Pommier, Yves
Publicado 2020

Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

por Nakamura, Kyoko, Kogame, Toshiaki, Oshiumi, Hiroyuki, Shinohara, Akira, Sumitomo, Yoshiki, Agama, Keli, Pommier, Yves, Tsutsui, Kimiko M., Tsutsui, Ken, Hartsuiker, Edgar, Ogi, Tomoo, Takeda, Shunichi, Taniguchi, Yoshihito
Publicado 2010

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

por Jensen, Niels Frank, Agama, Keli, Roy, Amit, Smith, David Hersi, Pfister, Thomas D., Rømer, Maria Unni, Zhang, Hong-Liang, Doroshow, James H., Knudsen, Birgitta R., Stenvang, Jan, Brünner, Nils, Pommier, Yves
Publicado 2016

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

por Elbadawi, Mostafa M., Eldehna, Wagdy M., Abd El-Hafeez, Amer Ali, Somaa, Warda R., Albohy, Amgad, Al-Rashood, Sara T., Agama, Keli K., Elkaeed, Eslam B., Ghosh, Pradipta, Pommier, Yves, Abe, Manabu
Publicado 2021

Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair

por Croglio, Michael P., Haake, Jefferson M., Ryan, Colin P., Wang, Victor S., Lapier, Jennifer, Schlarbaum, Jamie P., Dayani, Yaron, Artuso, Emma, Prandi, Cristina, Koltai, Hinanit, Agama, Keli, Pommier, Yves, Chen, Yu, Tricoli, Lucas, LaRocque, Jeannine R., Albanese, Christopher, Yarden, Ronit I.
Publicado 2016

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

por Tsuda, Masataka, Cho, Kosai, Ooka, Masato, Shimizu, Naoto, Watanabe, Reiko, Yasui, Akira, Nakazawa, Yuka, Ogi, Tomoo, Harada, Hiroshi, Agama, Keli, Nakamura, Jun, Asada, Ryuta, Fujiike, Haruna, Sakuma, Tetsushi, Yamamoto, Takashi, Murai, Junko, Hiraoka, Masahiro, Koike, Kaoru, Pommier, Yves, Takeda, Shunichi, Hirota, Kouji
Publicado 2017