Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction

por Garcia, Daniel A., Powers, Andrew F., Bell, Thomas A., Guo, Shuling, Aghajan, Mariam
Publicado 2022

Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations

por Huang, Lulu, Aghajan, Mariam, Quesenberry, Tianna, Low, Audrey, Murray, Susan F., Monia, Brett P., Guo, Shuling
Publicado 2019

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

por Zhang, Jun, Min, Robert W M, Le, Khanh, Zhou, Sheng, Aghajan, Mariam, Than, Tin A, Win, Sanda, Kaplowitz, Neil
Publicado 2017

Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity

por Iorga, Andrea, Donovan, Katherine, Shojaie, Layla, Johnson, Heather, Kwok, Janet, Suda, Jo, Lee, Brian T., Aghajan, Mariam, Shao, Ling, Liu, Zhang-Xu, Dara, Lily
Publicado 2021

Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency

por Prajapati, Milankumar, Zhang, Jared Z., Mercadante, Courtney J., Kowalski, Heather L., Delaney, Bradley, Anderson, Jessica A., Guo, Shuling, Aghajan, Mariam, Bartnikas, Thomas B.
Publicado 2023

A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity

por Ochaba, Joseph, Powers, Andrew F, Tremble, Kaitlyn A, Greenlee, Sarah, Post, Noah M, Matson, John E, MacLeod, A Robert, Guo, Shuling, Aghajan, Mariam
Publicado 2019

Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice

por Casu, Carla, Liu, Alison, De Rosa, Gianluca, Low, Audrey, Suzuki, Aae, Sinha, Sayantani, Ginzburg, Yelena Z., Abrams, Charles, Aghajan, Mariam, Guo, Shuling, Rivella, Stefano
Publicado 2021

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

por Cansby, Emmelie, Nuñez-Durán, Esther, Magnusson, Elin, Amrutkar, Manoj, Booten, Sheri L., Kulkarni, Nagaraj M., Svensson, L. Thomas, Borén, Jan, Marschall, Hanns-Ulrich, Aghajan, Mariam, Mahlapuu, Margit
Publicado 2018

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice

por Nuñez‐Durán, Esther, Aghajan, Mariam, Amrutkar, Manoj, Sütt, Silva, Cansby, Emmelie, Booten, Sheri L., Watt, Andrew, Ståhlman, Marcus, Stefan, Norbert, Häring, Hans‐Ulrich, Staiger, Harald, Borén, Jan, Marschall, Hanns‐Ulrich, Mahlapuu, Margit
Publicado 2017

Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver

por Yamada, Tatsuya, Murata, Daisuke, Kleiner, David E., Anders, Robert, Rosenberg, Avi Z., Kaplan, Jeffrey, Hamilton, James P., Aghajan, Mariam, Levi, Moshe, Wang, Nae-Yuh, Dawson, Ted M., Yanagawa, Toru, Powers, Andrew F., Iijima, Miho, Sesaki, Hiromi
Publicado 2022

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

por Viney, Nicholas J., Guo, Shuling, Tai, Li‐Jung, Baker, Brenda F., Aghajan, Mariam, Jung, Shiangtung W., Yu, Rosie Z., Booten, Sheri, Murray, Heather, Machemer, Todd, Burel, Sebastien, Murray, Sue, Buchele, Gustavo, Tsimikas, Sotirios, Schneider, Eugene, Geary, Richard S., Benson, Merrill D., Monia, Brett P.
Publicado 2020

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

por Prakash, Thazha P., Graham, Mark J., Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F., Riney, Stan, Booten, Sheri L., Murray, Susan F., Gaus, Hans, Crosby, Jeff, Lima, Walt F., Guo, Shuling, Monia, Brett P., Swayze, Eric E., Seth, Punit P.
Publicado 2014