ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question

por Aguiló, Nacho, Marinova, Dessislava, Martín, Carlos, Pardo, Julián
Publicado 2013

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

por Gonzalo-Asensio, Jesus, Marinova, Dessislava, Martin, Carlos, Aguilo, Nacho
Publicado 2017

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo

por Uranga, Santiago, Marinova, Dessislava, Martin, Carlos, Pardo, Julián, Aguilo, Nacho
Publicado 2016

MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

por Aguilo, Nacho, Uranga, Santiago, Marinova, Dessislava, Monzon, Marta, Badiola, Juan, Martin, Carlos
Publicado 2016

Natural Killer Anti-Tumor Activity Can Be Achieved by In Vitro Incubation With Heat-Killed BCG

por Esteso, Gloria, Aguiló, Nacho, Julián, Esther, Ashiru, Omodele, Ho, Mei. M., Martín, Carlos, Valés-Gómez, Mar
Publicado 2021

Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment

por Tarancón, Raquel, Mata, Elena, Uranga, Santiago, Gómez, Ana Belén, Marinova, Dessislava, Otal, Isabel, Martín, Carlos, Aguiló, Nacho
Publicado 2021

Cell death induced by cytotoxic CD8(+) T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

por Jaime-Sanchez, Paula, Uranga-Murillo, Iratxe, Aguilo, Nacho, Khouili, Sofia C, Arias, Maykel A, Sancho, David, Pardo, Julian
Publicado 2020

New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

por Gonzalo-Asensio, Jesús, Pérez, Irene, Aguiló, Nacho, Uranga, Santiago, Picó, Ana, Lampreave, Carlos, Cebollada, Alberto, Otal, Isabel, Samper, Sofía, Martín, Carlos
Publicado 2018

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

por Pérez, Irene, Uranga, Santiago, Sayes, Fadel, Frigui, Wafa, Samper, Sofía, Arbués, Ainhoa, Aguiló, Nacho, Brosch, Roland, Martín, Carlos, Gonzalo-Asensio, Jesús
Publicado 2020

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

por Pérez, Irene, Campos-Pardos, Elena, Díaz, Caridad, Uranga, Santiago, Sayes, Fadel, Vicente, Francisca, Aguiló, Nacho, Brosch, Roland, Martín, Carlos, Gonzalo-Asensio, Jesús
Publicado 2022

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

por Broset, Esther, Saubi, Narcís, Guitart, Núria, Aguilo, Nacho, Uranga, Santiago, Kilpeläinen, Athina, Eto, Yoshiki, Hanke, Tomáš, Gonzalo-Asensio, Jesús, Martín, Carlos, Joseph-Munné, Joan
Publicado 2019

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

por Aguilo, Nacho, Gonzalo-Asensio, Jesus, Alvarez-Arguedas, Samuel, Marinova, Dessislava, Gomez, Ana Belen, Uranga, Santiago, Spallek, Ralf, Singh, Mahavir, Audran, Regine, Spertini, François, Martin, Carlos
Publicado 2017

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference

por Mata, Elena, Farrell, Damien, Ma, Ruoyao, Uranga, Santiago, Gomez, Ana Belen, Monzon, Marta, Badiola, Juan, Anel, Alberto, Gonzalo-Asensio, Jesús, Martin, Carlos, Gordon, Stephen V., Aguilo, Nacho
Publicado 2020

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

por Tarancón, Raquel, Domínguez-Andrés, Jorge, Uranga, Santiago, Ferreira, Anaísa V., Groh, Laszlo A., Domenech, Mirian, González-Camacho, Fernando, Riksen, Niels P., Aguilo, Nacho, Yuste, José, Martín, Carlos, Netea, Mihai G.
Publicado 2020

BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

por Broset, Esther, Pardo-Seco, Jacobo, Kanno, Alex I., Aguilo, Nacho, Dacosta, Ana Isabel, Rivero-Calle, Irene, Gonzalo-Asensio, Jesus, Locht, Camille, Leite, Luciana C.C., Martin, Carlos, Martinón-Torres, Federico
Publicado 2021

BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro

por Esteso, Gloria, Felgueres, María José, García-Jiménez, Álvaro F., Reyburn-Valés, Christina, Benguría, Alberto, Vázquez, Enrique, Reyburn, Hugh T., Aguiló, Nacho, Martín, Carlos, Puentes, Eugenia, Murillo, Ingrid, Rodríguez, Esteban, Valés-Gómez, Mar
Publicado 2022

Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors

por Moreo, Eduardo, Uranga, Santiago, Picó, Ana, Gómez, Ana Belén, Nardelli-Haefliger, Denise, del Fresno, Carlos, Murillo, Ingrid, Puentes, Eugenia, Rodríguez, Esteban, Vales-Gómez, Mar, Pardo, Julian, Sancho, David, Martín, Carlos, Aguilo, Nacho
Publicado 2022

Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

por Roy, Alvaro, Tomé, Irene, Romero, Beatriz, Lorente-Leal, Víctor, Infantes-Lorenzo, José A., Domínguez, Mercedes, Martín, Carlos, Aguiló, Nacho, Puentes, Eugenia, Rodríguez, Esteban, de Juan, Lucía, Risalde, María A., Gortázar, Christian, Domínguez, Lucas, Bezos, Javier
Publicado 2019

Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

por Aguilo, Nacho, Uranga, Santiago, Mata, Elena, Tarancon, Raquel, Gómez, Ana Belén, Marinova, Dessislava, Otal, Isabel, Monzón, Marta, Badiola, Juan, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Vervenne, Richard A. W., Sombroek, Claudia C., Verreck, Frank A. W., Martín, Carlos
Publicado 2020

Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection

por Dijkman, Karin, Aguilo, Nacho, Boot, Charelle, Hofman, Sam O., Sombroek, Claudia C., Vervenne, Richard A.W., Kocken, Clemens H.M., Marinova, Dessislava, Thole, Jelle, Rodríguez, Esteban, Vierboom, Michel P.M., Haanstra, Krista G., Puentes, Eugenia, Martin, Carlos, Verreck, Frank A.W.
Publicado 2021