Impact of altered phosphorylation on loss of function of juvenile Parkinsonism–associated genetic variants of the E3 ligase parkin

por Aguirre, Jacob D., Dunkerley, Karen M., Lam, Rica, Rusal, Michele, Shaw, Gary S.
Publicado 2018

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

por Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S
Publicado 2018

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

por Spratt, Donald E., Julio Martinez-Torres, R, Noh, Yeong J., Mercier, Pascal, Manczyk, Noah, Barber, Kathryn R., Aguirre, Jacob D., Burchell, Lynn, Purkiss, Andrew, Walden, Helen, Shaw, Gary S.
Publicado 2013

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

por Kumar, Atul, Aguirre, Jacob D, Condos, Tara EC, Martinez-Torres, R Julio, Chaugule, Viduth K, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Mercier, Pascal, Knebel, Axel, Spratt, Donald E, Barber, Kathryn R, Shaw, Gary S, Walden, Helen
Publicado 2015

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

por Rabl, Julius, Bunker, Richard D., Schenk, Andreas D., Cavadini, Simone, Gill, Mark E., Abdulrahman, Wassim, Andrés-Pons, Amparo, Luijsterburg, Martijn S., Ibrahim, Adel F.M., Branigan, Emma, Aguirre, Jacob D., Marceau, Aimee H., Guérillon, Claire, Bouwmeester, Tewis, Hassiepen, Ulrich, Peters, Antoine H.F.M., Renatus, Martin, Gelman, Laurent, Rubin, Seth M., Mailand, Niels, van Attikum, Haico, Hay, Ronald T., Thomä, Nicolas H.
Publicado 2019