Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β

por Toyn, Jeremy H, Ahlijanian, Michael K
Publicado 2014

A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

por Qureshi, Irfan A., Tirucherai, Giridhar, Ahlijanian, Michael K., Kolaitis, Gerry, Bechtold, Clifford, Grundman, Michael
Publicado 2018

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

por Sivarao, Digavalli V., Chen, Ping, Yang, Yili, Li, Yu-Wen, Pieschl, Rick, Ahlijanian, Michael K.
Publicado 2014

APP processing is regulated by cytoplasmic phosphorylation

por Lee, Ming-Sum, Kao, Shih-Chu, Lemere, Cynthia A., Xia, Weiming, Tseng, Huang-Chun, Zhou, Ying, Neve, Rachael, Ahlijanian, Michael K., Tsai, Li-Huei
Publicado 2003

Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury

por Shin, Samuel S., Mazandi, Vanessa M., Schneider, Andrea L. C., Morton, Sarah, Starr, Jonathan P., Weeks, M. Katie, Widmann, Nicholas J., Jang, David H., Kao, Shih-Han, Ahlijanian, Michael K., Kilbaugh, Todd J.
Publicado 2023

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

por Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz
Publicado 2016

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

por Rusilowicz-Jones, Emma V, Jardine, Jane, Kallinos, Andreas, Pinto-Fernandez, Adan, Guenther, Franziska, Giurrandino, Mariacarmela, Barone, Francesco G, McCarron, Katy, Burke, Christopher J, Murad, Alejandro, Martinez, Aitor, Marcassa, Elena, Gersch, Malte, Buckmelter, Alexandre J, Kayser-Bricker, Katherine J, Lamoliatte, Frederic, Gajbhiye, Akshada, Davis, Simon, Scott, Hannah C, Murphy, Emma, England, Katherine, Mortiboys, Heather, Komander, David, Trost, Matthias, Kessler, Benedikt M, Ioannidis, Stephanos, Ahlijanian, Michael K, Urbé, Sylvie, Clague, Michael J
Publicado 2020

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

por Boy, Kenneth M., Guernon, Jason M., Zuev, Dmitry S., Xu, Li, Zhang, Yunhui, Shi, Jianliang, Marcin, Lawrence R., Higgins, Mendi A., Wu, Yong-Jin, Krishnananthan, Subramaniam, Li, Jianqing, Trehan, Ashok, Smith, Daniel, Toyn, Jeremy H., Meredith, Jere E., Burton, Catherine R., Kimura, S. Roy, Zvyaga, Tatyana, Zhuo, Xiaoliang, Lentz, Kimberley A., Grace, James E., Denton, Rex, Morrison, John S., Mathur, Arvind, Albright, Charles F., Ahlijanian, Michael K., Olson, Richard E., Thompson, Lorin A., Macor, John E.
Publicado 2019

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

por Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.
Publicado 2016

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

por Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Publicado 2014