Phase 1 Study to Assess the Safety and Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Subjects Without Cystic Fibrosis With Moderate Hepatic Impairment

por Viswanathan, Lakshmi, Bachman, Eric, Tian, Simon, Ahluwalia, Neil, Zhang, Yaohua, Bernstein, Harold S., Panorchan, Paul
Publicado 2022

Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events

por Schwarz, Carsten, Sutharsan, Sivagurunathan, Epaud, Ralph, Klingsberg, Ross C., Fischer, Rainald, Rowe, Steven M., Audhya, Paul K., Ahluwalia, Neil, You, Xiaojun, Ferro, Thomas J., Duncan, Margaret E., Bruinsma, Bote G.
Publicado 2021

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

por Lagares, David, Ghassemi-Kakroodi, Parisa, Tremblay, Caroline, Santos, Alba, Probst, Clemens K., Franklin, Alicia, Santos, Daniela M., Grasberger, Paula, Ahluwalia, Neil, Montesi, Sydney B., Shea, Barry S., Black, Katharine E., Knipe, Rachel, Blati, Meryem, Baron, Murray, Wu, Brian, Fahmi, Hassan, Gandhi, Rajiv, Pardo, Annie, Selman, Moisés, Wu, Jiangping, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Tager, Andrew M., Kapoor, Mohit
Publicado 2017

A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One F508del Allele

por Zemanick, Edith T., Taylor-Cousar, Jennifer L., Davies, Jane, Gibson, Ronald L., Mall, Marcus A., McKone, Edward F., McNally, Paul, Ramsey, Bonnie W., Rayment, Jonathan H., Rowe, Steven M., Tullis, Elizabeth, Ahluwalia, Neil, Chu, Chenghao, Ho, Thang, Moskowitz, Samuel M., Noel, Sabrina, Tian, Simon, Waltz, David, Weinstock, Tanya G., Xuan, Fengjuan, Wainwright, Claire E., McColley, Susanna A.
Publicado 2021

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase...

por Mall, Marcus A., Brugha, Rossa, Gartner, Silvia, Legg, Julian, Moeller, Alexander, Mondejar-Lopez, Pedro, Prais, Dario, Pressler, Tacjana, Ratjen, Felix, Reix, Philippe, Robinson, Paul D., Selvadurai, Hiran, Stehling, Florian, Ahluwalia, Neil, Arteaga-Solis, Emilio, Bruinsma, Bote G., Jennings, Mark, Moskowitz, Samuel M., Noel, Sabrina, Tian, Simon, Weinstock, Tanya G., Wu, Pan, Wainwright, Claire E., Davies, Jane C.
Publicado 2022