CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

por Cimo, Ann-Marie, Ahmed, Zamal, McIntyre, Bradley W., Lewis, Dorothy E., Ladbury, John E.
Publicado 2013

Grb2 binding induces phosphorylation-independent activation of Shp2

por Lin, Chi-Chuan, Wieteska, Lukasz, Suen, Kin Man, Kalverda, Arnout P., Ahmed, Zamal, Ladbury, John E.
Publicado 2021

The combined action of the intracellular regions regulates FGFR2 kinase activity

por Lin, Chi-Chuan, Wieteska, Lukasz, Poncet-Montange, Guillaume, Suen, Kin Man, Arold, Stefan T., Ahmed, Zamal, Ladbury, John E.
Publicado 2023

T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

por Stevens, Claire N., Simeone, Ann-Marie, John, Susan, Ahmed, Zamal, Lucherini, Orso M., Baldari, C. Tatiana, Ladbury, John E.
Publicado 2010

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

por Ahmed, Zamal, Lin, Chi-Chuan, Suen, Kin M., Melo, Fernando A., Levitt, James A, Suhling, Klaus, Ladbury, John E.
Publicado 2013

Regulation of microRNA expression by the adaptor protein GRB2

por Stainthorp, Amy K., Lin, Chi-Chuan, Wang, Dapeng, Medhi, Ragini, Ahmed, Zamal, Suen, Kin Man, Miska, Eric A., Whitehouse, Adrian, Ladbury, John E.
Publicado 2023

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

por Ahmed, Zamal, Timsah, Zahra, Suen, Kin M., Cook, Nathan P., Lee, Gilbert R., Lin, Chi-Chuan, Gagea, Mihai, Marti, Angel A., Ladbury, John E.
Publicado 2015

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

por Ahmed, Zamal, Timsah, Zahra, Suen, Kin M., Cook, Nathan P., Lee IV, Gilbert R., Lin, Chi-Chuan, Gagea, Mihai, Marti, Angel A., Ladbury, John E.
Publicado 2015

Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity

por Munoz, William A., Lee, Moonsup, Miller, Rachel K., Ahmed, Zamal, Ji, Hong, Link, Todd M., Lee, Gilbert R., Kloc, Malgorzata, Ladbury, John E., McCrea, Pierre D.
Publicado 2014

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin

por Bacolla, Albino, Sengupta, Shiladitya, Ye, Zu, Yang, Chunying, Mitra, Joy, De-Paula, Ruth B, Hegde, Muralidhar L, Ahmed, Zamal, Mort, Matthew, Cooper, David N, Mitra, Sankar, Tainer, John A
Publicado 2020

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

por Moiani, Davide, Link, Todd M., Brosey, Chris A., Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E., Tsutakawa, Susan E., Tainer, John A.
Publicado 2021

GRB2 enforces homology-directed repair initiation by MRE11

por Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G., Jones, Darin E., Wang, Bin, Tainer, John A., Ahmed, Zamal
Publicado 2021

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

por Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Publicado 2021

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

por Nguyen, My T., Moiani, Davide, Ahmed, Zamal, Arvai, Andrew S., Namjoshi, Sarita, Shin, Dave S., Fedorov, Yuriy, Selvik, Edward J., Jones, Darin E., Pink, John, Yan, Yan, Laverty, Daniel J., Nagel, Zachary D., Tainer, John A., Gerson, Stanton L.
Publicado 2021

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

por Lin, Chi-Chuan, Suen, Kin Man, Jeffrey, Polly-Anne, Wieteska, Lukasz, Lidster, Jessica A., Bao, Peng, Curd, Alistair P., Stainthorp, Amy, Seiler, Caroline, Koss, Hans, Miska, Eric, Ahmed, Zamal, Evans, Stephen D., Molina-París, Carmen, Ladbury, John E.
Publicado 2022

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

por Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Publicado 2019