Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the...

por Kim, Jihee, Ahn, Seungkirl, Rajagopal, Keshava, Lefkowitz, Robert J.
Publicado 2009

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

por Li, Angus, Liu, Samuel, Huang, Rennica, Ahn, Seungkirl, Lefkowitz, Robert J.
Publicado 2023

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

por Ahn, Seungkirl, Kim, Jihee, Hara, Makoto R., Ren, Xiu-Rong, Lefkowitz, Robert J.
Publicado 2009

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4

por Shukla, Arun K., Kim, Jihee, Ahn, Seungkirl, Xiao, Kunhong, Shenoy, Sudha K., Liedtke, Wolfgang, Lefkowitz, Robert J.
Publicado 2010

Allosteric modulator potentiates β(2)AR agonist–promoted bronchoprotection in asthma models

por Ahn, Seungkirl, Maarsingh, Harm, Walker, Julia K.L., Liu, Samuel, Hegde, Akhil, Sumajit, Hyeje C., Kahsai, Alem W., Lefkowitz, Robert J.
Publicado 2023

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor

por Weiss, Dahlia R., Ahn, SeungKirl, Sassano, Maria F., Kleist, Andrew, Zhu, Xiao, Strachan, Ryan, Roth, Bryan L., Lefkowitz, Robert J., Shoichet, Brian K.
Publicado 2013

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

por Pani, Biswaranjan, Ahn, Seungkirl, Rambarat, Paula K., Vege, Shashank, Kahsai, Alem W., Liu, Andrew, Valan, Bruno N., Staus, Dean P., Costa, Tommaso, Lefkowitz, Robert J.
Publicado 2021

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

por Kahsai, Alem W., Shah, Kunal S., Shim, Paul J., Lee, Mason A., Shreiber, Bowie N., Schwalb, Allison M., Zhang, Xingdong, Kwon, Henry Y., Huang, Li-Yin, Soderblom, Erik J., Ahn, Seungkirl, Lefkowitz, Robert J.
Publicado 2023

Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

por Heitzler, Domitille, Durand, Guillaume, Gallay, Nathalie, Rizk, Aurélien, Ahn, Seungkirl, Kim, Jihee, Violin, Jonathan D, Dupuy, Laurence, Gauthier, Christophe, Piketty, Vincent, Crépieux, Pascale, Poupon, Anne, Clément, Frédérique, Fages, François, Lefkowitz, Robert J, Reiter, Eric
Publicado 2012

How carvedilol does not activate β(2)-adrenoceptors

por Lefkowitz, Robert J., Rockman, Howard A., Shim, Paul J., Liu, Samuel, Ahn, Seungkirl, Pani, Biswaranjan, Rajagopal, Sudarshan, Shenoy, Sudha K., Bouvier, Michel, Benovic, Jeffrey L., Liggett, Stephen B., Ruffolo, Robert R., Bristow, Michael R., Packer, Milton
Publicado 2023

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation

por Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R. Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Publicado 2016

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

por Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicado 2013

Conformationally Selective RNA Aptamers Allosterically Modulate the β(2)-Adrenoceptor

por Kahsai, Alem W., Wisler, James W., Lee, Jungmin, Ahn, Seungkirl, Cahill, Thomas J., Dennison, S. Moses, Staus, Dean P., Thomsen, Alex R. B., Anasti, Kara M., Pani, Biswaranjan, Wingler, Laura M., Desai, Hemant, Bompiani, Kristin M., Strachan, Ryan T., Qin, Xiaoxia, Alam, S. Munir, Sullenger, Bruce A., Lefkowitz, Robert J.
Publicado 2016

Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries

por Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T., Sun, Lillian D., Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J.
Publicado 2018