PM492. Schizophrenia patient-derived induced pluripotent stem cells exhibit changes in neurogenic and gliogenic competences

por Toyoshima, Manabu, Akamatsu, Wado, Okada, Yohei, Okano, Hideyuki, Yoshikawa, Takeo
Publicado 2016

Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells

por Fujimori, Koki, Matsumoto, Takuya, Kisa, Fumihiko, Hattori, Nobutaka, Okano, Hideyuki, Akamatsu, Wado
Publicado 2017

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes

por Imaizumi, Kent, Sone, Takefumi, Ibata, Keiji, Fujimori, Koki, Yuzaki, Michisuke, Akamatsu, Wado, Okano, Hideyuki
Publicado 2015

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

por Yokota, Mutsumi, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Publicado 2021

Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest‐like precursors

por Takayama, Yuzo, Wakabayashi, Tamami, Kushige, Hiroko, Saito, Yutaka, Shibuya, Yoichiro, Shibata, Shinsuke, Akamatsu, Wado, Okano, Hideyuki, Kida, Yasuyuki S.
Publicado 2017

Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity

por Sasaki, Ritsuko, Kurebayashi, Nagomi, Eguchi, Hidetaka, Horimoto, Yoshiya, Shiga, Takahiro, Miyazaki, Sakiko, Kashiyama, Taku, Akamatsu, Wado, Saito, Mitsue
Publicado 2022

A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease

por Nakamura, Ryota, Nonaka, Risa, Oyama, Genko, Jo, Takayuki, Kamo, Hikaru, Nuermaimaiti, Maierdanjiang, Akamatsu, Wado, Ishikawa, Kei-ichi, Hattori, Nobutaka
Publicado 2023

Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors

por Zhou, Zhi, Kohda, Kazuhisa, Ibata, Keiji, Kohyama, Jun, Akamatsu, Wado, Yuzaki, Michisuke, Okano, Hirotaka James, Sasaki, Erika, Okano, Hideyuki
Publicado 2014

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

por Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Sano, Osamu, Iwata, Hidehisa, Ishikawa, Kei-ichi, Okano, Hideyuki, Akamatsu, Wado, Imai, Yuzuru, Hattori, Nobutaka
Publicado 2020

Generation of Human Melanocytes from Induced Pluripotent Stem Cells

por Ohta, Shigeki, Imaizumi, Yoichi, Okada, Yohei, Akamatsu, Wado, Kuwahara, Reiko, Ohyama, Manabu, Amagai, Masayuki, Matsuzaki, Yumi, Yamanaka, Shinya, Okano, Hideyuki, Kawakami, Yutaka
Publicado 2011

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

por Yoshida, Tetsu, Ozawa, Yoko, Suzuki, Keiichiro, Yuki, Kenya, Ohyama, Manabu, Akamatsu, Wado, Matsuzaki, Yumi, Shimmura, Shigeto, Mitani, Kohnosuke, Tsubota, Kazuo, Okano, Hideyuki
Publicado 2014

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling

por Imaizumi, Kent, Fujimori, Koki, Ishii, Seiji, Otomo, Asako, Hosoi, Yasushi, Miyajima, Hiroaki, Warita, Hitoshi, Aoki, Masashi, Hadano, Shinji, Akamatsu, Wado, Okano, Hideyuki
Publicado 2018

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

por Nishihara, Koji, Shiga, Takahiro, Nakamura, Eri, Akiyama, Tomohiko, Sasaki, Takashi, Suzuki, Sadafumi, Ko, Minoru S.H., Tada, Norihiro, Okano, Hideyuki, Akamatsu, Wado
Publicado 2019

Reduced ER-mitochondrial contact sites and mitochondrial Ca(2+) flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

por Yokota, Mutsumi, Yoshino, Yutaro, Hosoi, Mitsuko, Hashimoto, Ryota, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-Ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Publicado 2023

Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research

por Yagi, Takuya, Kosakai, Arifumi, Ito, Daisuke, Okada, Yohei, Akamatsu, Wado, Nihei, Yoshihiro, Nabetani, Akira, Ishikawa, Fuyuki, Arai, Yasumichi, Hirose, Nobuyoshi, Okano, Hideyuki, Suzuki, Norihiro
Publicado 2012

Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease

por Ueno, Shin-Ichi, Saiki, Shinji, Fujimaki, Motoki, Takeshige-Amano, Haruka, Hatano, Taku, Oyama, Genko, Ishikawa, Kei-Ichi, Yamaguchi, Akihiro, Nojiri, Shuko, Akamatsu, Wado, Hattori, Nobutaka
Publicado 2018

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2

por Torii, Satoru, Arakawa, Satoko, Sato, Shigeto, Ishikawa, Kei‐ichi, Taniguchi, Daisuke, Sakurai, Hajime Tajima, Honda, Shinya, Hiraoka, Yuuichi, Ono, Masaya, Akamatsu, Wado, Hattori, Nobutaka, Shimizu, Shigeomi
Publicado 2023

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

por Andoh-Noda, Tomoko, Akamatsu, Wado, Miyake, Kunio, Matsumoto, Takuya, Yamaguchi, Ryo, Sanosaka, Tsukasa, Okada, Yohei, Kobayashi, Tetsuro, Ohyama, Manabu, Nakashima, Kinichi, Kurosawa, Hiroshi, Kubota, Takeo, Okano, Hideyuki
Publicado 2015

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

por Suda, Yukari, Kuzumaki, Naoko, Sone, Takefumi, Narita, Michiko, Tanaka, Kenichi, Hamada, Yusuke, Iwasawa, Chizuru, Shibasaki, Masahiro, Maekawa, Aya, Matsuo, Miri, Akamatsu, Wado, Hattori, Nobutaka, Okano, Hideyuki, Narita, Minoru
Publicado 2018

A human Dravet syndrome model from patient induced pluripotent stem cells

por Higurashi, Norimichi, Uchida, Taku, Lossin, Christoph, Misumi, Yoshio, Okada, Yohei, Akamatsu, Wado, Imaizumi, Yoichi, Zhang, Bo, Nabeshima, Kazuki, Mori, Masayuki X, Katsurabayashi, Shutaro, Shirasaka, Yukiyoshi, Okano, Hideyuki, Hirose, Shinichi
Publicado 2013