Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes

por Sumaoka, Jun, Akiba, Hiroki, Komiyama, Makoto
Publicado 2016

Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design

por Akiba, Hiroki, Satoh, Reiko, Nagata, Satoshi, Tsumoto, Kouhei
Publicado 2019

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

por Akiba, Hiroki, Ise, Tomoko, Nagata, Satoshi, Kamada, Haruhiko, Ohno, Hiroaki, Tsumoto, Kouhei
Publicado 2021

Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher

por Akiba, Hiroki, Takayanagi, Kensuke, Kusano-Arai, Osamu, Iwanari, Hiroko, Hamakubo, Takao, Tsumoto, Kouhei
Publicado 2020

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

por Akiba, Hiroki, Tamura, Hiroko, Kiyoshi, Masato, Yanaka, Saeko, Sugase, Kenji, Caaveiro, Jose M. M., Tsumoto, Kouhei
Publicado 2019

Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support

por Ito, Toshihiro, Minamitani, Takeharu, Hayakawa, Masaki, Otsubo, Ryota, Akiba, Hiroki, Tsumoto, Kouhei, Matsumoto, Masanori, Yasui, Teruhito
Publicado 2021

Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

por Minamitani, Takeharu, Kiyose, Karin, Otsubo, Ryota, Ito, Toshihiro, Akiba, Hiroki, Furuta, Rika A., Inoue, Tsuyoshi, Tsumoto, Kouhei, Satake, Masahiro, Yasui, Teruhito
Publicado 2021

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection

por Akiba, Hiroki, Fujita, Junso, Ise, Tomoko, Nishiyama, Kentaro, Miyata, Tomoko, Kato, Takayuki, Namba, Keiichi, Ohno, Hiroaki, Kamada, Haruhiko, Nagata, Satoshi, Tsumoto, Kouhei
Publicado 2023

(111)In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis

por Fujiwara, Kentaro, Tsuji, Atsushi B., Sudo, Hitomi, Sugyo, Aya, Akiba, Hiroki, Iwanari, Hiroko, Kusano-Arai, Osamu, Tsumoto, Kouhei, Momose, Toshimitsu, Hamakubo, Takao, Higashi, Tatsuya
Publicado 2019

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

por Kato, Daiki, Yaguchi, Tomonori, Iwata, Takashi, Katoh, Yuki, Morii, Kenji, Tsubota, Kinya, Takise, Yoshiaki, Tamiya, Masaki, Kamada, Haruhiko, Akiba, Hiroki, Tsumoto, Kouhei, Serada, Satoshi, Naka, Tetsuji, Nishimura, Ryohei, Nakagawa, Takayuki, Kawakami, Yutaka
Publicado 2020