Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

por Suzuki, Naoki, Akiyama, Tetsuya, Warita, Hitoshi, Aoki, Masashi
Publicado 2020

Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers

por Akiyama, Tetsuya, Koike, Yuka, Petrucelli, Leonard, Gitler, Aaron D.
Publicado 2022

An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3

por Watanabe, Yasuaki, Nakagawa, Tadashi, Akiyama, Tetsuya, Nakagawa, Makiko, Suzuki, Naoki, Warita, Hitoshi, Aoki, Masashi, Nakayama, Keiko
Publicado 2020

TARDBP p.G376D mutation, found in rapid progressive familial ALS, induces mislocalization of TDP-43

por Mitsuzawa, Shio, Akiyama, Tetsuya, Nishiyama, Ayumi, Suzuki, Naoki, Kato, Masaaki, Warita, Hitoshi, Izumi, Rumiko, Osana, Shion, Koyama, Shingo, Kato, Takeo, Suzuki, Yoshihiro, Aoki, Masashi
Publicado 2018

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

por Kim, Garam, Nakayama, Lisa, Blum, Jacob A., Akiyama, Tetsuya, Boeynaems, Steven, Chakraborty, Meenakshi, Couthouis, Julien, Tassoni-Tsuchida, Eduardo, Rodriguez, Caitlin M., Bassik, Michael C., Gitler, Aaron D.
Publicado 2022

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells

por Ichiyanagi, Naoki, Fujimori, Koki, Yano, Masato, Ishihara-Fujisaki, Chikako, Sone, Takefumi, Akiyama, Tetsuya, Okada, Yohei, Akamatsu, Wado, Matsumoto, Takuya, Ishikawa, Mitsuru, Nishimoto, Yoshinori, Ishihara, Yasuharu, Sakuma, Tetsushi, Yamamoto, Takashi, Tsuiji, Hitomi, Suzuki, Naoki, Warita, Hitoshi, Aoki, Masashi, Okano, Hideyuki
Publicado 2016

AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy

por Ono, Hiroya, Suzuki, Naoki, Kanno, Shin-ichiro, Kawahara, Genri, Izumi, Rumiko, Takahashi, Toshiaki, Kitajima, Yasuo, Osana, Shion, Nakamura, Naoko, Akiyama, Tetsuya, Ikeda, Kensuke, Shijo, Tomomi, Mitsuzawa, Shio, Nagatomi, Ryoichi, Araki, Nobukazu, Yasui, Akira, Warita, Hitoshi, Hayashi, Yukiko K., Miyake, Katsuya, Aoki, Masashi
Publicado 2020

Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations

por Mitsuzawa, Shio, Suzuki, Naoki, Akiyama, Tetsuya, Ishikawa, Mitsuru, Sone, Takefumi, Kawada, Jiro, Funayama, Ryo, Shirota, Matsuyuki, Mitsuhashi, Hiroaki, Morimoto, Satoru, Ikeda, Kensuke, Shijo, Tomomi, Ohno, Akiyuki, Nakamura, Naoko, Ono, Hiroya, Ono, Risako, Osana, Shion, Nakagawa, Tadashi, Nishiyama, Ayumi, Izumi, Rumiko, Kaneda, Shohei, Ikeuchi, Yoshiho, Nakayama, Keiko, Fujii, Teruo, Warita, Hitoshi, Okano, Hideyuki, Aoki, Masashi
Publicado 2021

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

por Akiyama, Tetsuya, Suzuki, Naoki, Ishikawa, Mitsuru, Fujimori, Koki, Sone, Takefumi, Kawada, Jiro, Funayama, Ryo, Fujishima, Fumiyoshi, Mitsuzawa, Shio, Ikeda, Kensuke, Ono, Hiroya, Shijo, Tomomi, Osana, Shion, Shirota, Matsuyuki, Nakagawa, Tadashi, Kitajima, Yasuo, Nishiyama, Ayumi, Izumi, Rumiko, Morimoto, Satoru, Okada, Yohei, Kamei, Takayuki, Nishida, Mayumi, Nogami, Masahiro, Kaneda, Shohei, Ikeuchi, Yoshiho, Mitsuhashi, Hiroaki, Nakayama, Keiko, Fujii, Teruo, Warita, Hitoshi, Okano, Hideyuki, Aoki, Masashi
Publicado 2019

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

por Ma, X. Rosa, Prudencio, Mercedes, Koike, Yuka, Vatsavayai, Sarat C., Kim, Garam, Harbinski, Fred, Briner, Adam, Rodriguez, Caitlin M., Guo, Caiwei, Akiyama, Tetsuya, Schmidt, H. Broder, Cummings, Beryl B., Wyatt, David W., Kurylo, Katherine, Miller, Georgiana, Mekhoubad, Shila, Sallee, Nathan, Mekonnen, Gemechu, Ganser, Laura, Rubien, Jack D., Jansen-West, Karen, Cook, Casey N., Pickles, Sarah, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Shorter, James, Myong, Sua, Green, Eric M., Seeley, William W., Petrucelli, Leonard, Gitler, Aaron D.
Publicado 2022