Small molecules reveal an alternative mechanism of Bax activation

por Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
Publicado 2016

G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

por Varney, Matthew J., Steyaert, Wouter, Coucke, Paul J., Delanghe, Joris R., Uehling, David E., Joseph, Babu, Marcellus, Richard, Al-awar, Rima, Benovic, Jeffrey L.
Publicado 2022

G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions

por Ganguly, Amlan, Quon, Tezz, Jenkins, Laura, Joseph, Babu, Al-awar, Rima, Chevigne, Andy, Tobin, Andrew B., Uehling, David E., Hoffmann, Carsten, Drube, Julia, Milligan, Graeme
Publicado 2023

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

por Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
Publicado 2020

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

por Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
Publicado 2016

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

por Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Publicado 2014

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

por Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.
Publicado 2021

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

por Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Publicado 2015

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

por Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
Publicado 2016

The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia

por Edilova, Maria I., Law, Jaclyn C., Zangiabadi, Safoura, Ting, Kenneth, Mbanwi, Achire N., Arruda, Andrea, Uehling, David, Isaac, Methvin, Prakesch, Michael, Al-awar, Rima, Minden, Mark D., Abdul-Sater, Ali A., Watts, Tania H.
Publicado 2021

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

por Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A., Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P., Adamson, Roslin, Bullock, Alex N., Kiyota, Taira, Aman, Ahmed, Roberts, Owen G., Edwards, Aled M., O’Meara, Jeff A., Isaac, Methvin B., Al-awar, Rima
Publicado 2020

Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

por Grinshtein, Natalie, Rioseco, Constanza C., Marcellus, Richard, Uehling, David, Aman, Ahmed, Lun, Xueqing, Muto, Osamu, Podmore, Lauren, Lever, Jake, Shen, Yaoqing, Blough, Michael D., Cairncross, Greg J., Robbins, Stephen M., Jones, Steven J., Marra, Marco A., Al-Awar, Rima, Senger, Donna L., Kaplan, David R.
Publicado 2016

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

por Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado 2012

Structure and mechanism of action of the hydroxy aryl aldehyde class of IRE1 endoribonuclease inhibitors

por Sanches, Mario, Duffy, Nicole M., Talukdar, Manisha, Thevakumaran, Nero, Chiovitti, David, Canny, Marella D., Lee, Kenneth, Kurinov, Igor, Uehling, David, Al-awar, Rima, Poda, Gennadiy, Prakesch, Michael, Wilson, Brian, Tam, Victor, Schweitzer, Colleen, Toro, Andras, Lucas, Julie L., Vuga, Danka, Lehmann, Lynn, Durocher, Daniel, Zeng, Qingping, Patterson, John B., Sicheri, Frank
Publicado 2014

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

por Moustakim, Moses, Christott, Thomas, Monteiro, Octovia P., Bennett, James, Giroud, Charline, Ward, Jennifer, Rogers, Catherine M., Smith, Paul, Panagakou, Ioanna, Díaz‐Sáez, Laura, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Halidi, Nadia, Heidenreich, David, Chaikuad, Apirat, Knapp, Stefan, Huber, Kilian V. M., Farnie, Gillian, Heer, Jag, Manevski, Nenad, Poda, Gennady, Al‐awar, Rima, Dixon, Darren J., Brennan, Paul E., Fedorov, Oleg
Publicado 2018

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

por Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V. M., Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J., Zuber, Johannes, Bennett, Keiryn L., Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H., Superti-Furga, Giulio
Publicado 2015

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

por Szewczyk, Magdalena M., Ishikawa, Yoshinori, Organ, Shawna, Sakai, Nozomu, Li, Fengling, Halabelian, Levon, Ackloo, Suzanne, Couzens, Amber L., Eram, Mohammad, Dilworth, David, Fukushi, Hideto, Harding, Rachel, dela Seña, Carlo C., Sugo, Tsukasa, Hayashi, Kozo, McLeod, David, Zepeda, Carlos, Aman, Ahmed, Sánchez-Osuna, Maria, Bonneil, Eric, Takagi, Shinji, Al-Awar, Rima, Tyers, Mike, Richard, Stephane, Takizawa, Masayuki, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Nara, Hiroshi, Barsyte-Lovejoy, Dalia
Publicado 2020

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

por Szewczyk, Magdalena M., Ishikawa, Yoshinori, Organ, Shawna, Sakai, Nozomu, Li, Fengling, Halabelian, Levon, Ackloo, Suzanne, Couzens, Amber L., Eram, Mohammad, Dilworth, David, Fukushi, Hideto, Harding, Rachel, dela Seña, Carlo C., Sugo, Tsukasa, Hayashi, Kozo, McLeod, David, Zepeda, Carlos, Aman, Ahmed, Sánchez-Osuna, Maria, Bonneil, Eric, Takagi, Shinji, Al-Awar, Rima, Tyers, Mike, Richard, Stephane, Takizawa, Masayuki, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Nara, Hiroshi, Barsyte-Lovejoy, Dalia
Publicado 2020

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

por Anderson, Nathaniel D., Babichev, Yael, Fuligni, Fabio, Comitani, Federico, Layeghifard, Mehdi, Venier, Rosemarie E., Dentro, Stefan C., Maheshwari, Anant, Guram, Sheena, Wunker, Claire, Thompson, J. Drew, Yuki, Kyoko E., Hou, Huayun, Zatzman, Matthew, Light, Nicholas, Bernardini, Marcus Q., Wunder, Jay S., Andrulis, Irene L., Ferguson, Peter, Razak, Albiruni R. Abdul, Swallow, Carol J., Dowling, James J., Al-Awar, Rima S., Marcellus, Richard, Rouzbahman, Marjan, Gerstung, Moritz, Durocher, Daniel, Alexandrov, Ludmil B., Dickson, Brendan C., Gladdy, Rebecca A., Shlien, Adam
Publicado 2021

Discovery of Nanomolar DCAF1 Small Molecule Ligands

por Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud
Publicado 2023