Dityrosine cross-linking and its potential roles in Alzheimer’s disease

por Maina, Mahmoud B., Al-Hilaly, Youssra K., Serpell, Louise C.
Publicado 2023

Nuclear Tau and Its Potential Role in Alzheimer’s Disease

por Bukar Maina, Mahmoud, Al-Hilaly, Youssra K., Serpell, Louise C.
Publicado 2016

Shapeshifting tau: from intrinsically disordered to paired-helical filaments

por Mengham, Kurtis, Al-Hilaly, Youssra, Oakley, Sebastian, Kasbi, Kamillia, Maina, Mahmoud B., Serpell, Louise C.
Publicado 2022

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

por Maina, Mahmoud B., Burra, Gunasekhar, Al-Hilaly, Youssra K., Mengham, Kurtis, Fennell, Kate, Serpell, Louise C.
Publicado 2020

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

por Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra K., Xue, Wei-Feng, McGeehan, John E., Atack, John R., Serpell, Louise
Publicado 2019

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target

por Oakley, Sebastian S., Maina, Mahmoud B., Marshall, Karen E., Al-Hilaly, Youssra K., Harrington, Charlie R., Wischik, Claude M., Serpell, Louise C.
Publicado 2020

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

por Maina, Mahmoud B., Al-Hilaly, Youssra K., Burra, Gunasekhar, Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Publicado 2021

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image...

por Lutter, Liisa, Al-Hilaly, Youssra K., Serpell, Christopher J., Tuite, Mick F., Wischik, Claude M., Serpell, Louise C., Xue, Wei-Feng
Publicado 2022

Corrigendum: The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

por Lyu, Chen, Da Vela, Stefano, Al-Hilaly, Youssra, Marshall, Karen E., Thorogate, Richard, Svergun, Dmitri, Serpell, Louise C., Pastore, Annalisa, Hanger, Diane P.
Publicado 2023

The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

por Lyu, Chen, Da Vela, Stefano, Al-Hilaly, Youssra, Marshall, Karen E., Thorogate, Richard, Svergun, Dmitri, Serpell, Louise C., Pastore, Annalisa, Hanger, Diane P.
Publicado 2021

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

por Al-Hilaly, Youssra K., Hurt, Connor, Rickard, Janet E., Harrington, Charles R., Storey, John M. D., Wischik, Claude M., Serpell, Louise C., Siemer, Ansgar B.
Publicado 2022

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

por Al-Hilaly, Youssra K., Biasetti, Luca, Blakeman, Ben J. F., Pollack, Saskia J., Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R., Xue, Wei-Feng, Serpell, Louise C.
Publicado 2016

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

por Marshall, Karen E., Vadukul, Devkee M., Dahal, Liza, Theisen, Alina, Fowler, Milena W., Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J., Staras, Kevin, Serpell, Louise C.
Publicado 2016

Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells

por Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Publicado 2020

Using chirality to influence supramolecular gelation

por McAulay, Kate, Dietrich, Bart, Su, Hao, Scott, Michael T., Rogers, Sarah, Al-Hilaly, Youssra K., Cui, Honggang, Serpell, Louise C., Seddon, Annela M., Draper, Emily R., Adams, Dave J.
Publicado 2019

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

por Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William Grant, Morris, Kyle L, Sada, Alaa Abdul, Thorpe, Julian R, Serpell, Louise C
Publicado 2013

Chiral Co(3)Y Propeller-Shaped Chemosensory Platforms Based on (19)F-NMR

por Audsley, Gabrielle, Carpenter, Harry, Essien, Nsikak B., Lai-Morrice, James, Al-Hilaly, Youssra, Serpell, Louise C., Akien, Geoffrey R., Tizzard, Graham J., Coles, Simon J., Ulldemolins, Cristina Pubill, Kostakis, George E.
Publicado 2023

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

por Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.
Publicado 2019

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

por Fichou, Yann, Al-Hilaly, Youssra K., Devred, François, Smet-Nocca, Caroline, Tsvetkov, Philipp O., Verelst, Joke, Winderickx, Joris, Geukens, Nick, Vanmechelen, Eugeen, Perrotin, Audrey, Serpell, Louise, Hanseeuw, Bernard J, Medina, Miguel, Buée, Luc, Landrieu, Isabelle
Publicado 2019

The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation

por Ruiz-Zamora, Robin Axel, Guillaumé, Simon, Al-Hilaly, Youssra K., Al-Garawi, Zahraa, Rodríguez-Alvarez, Francisco Javier, Zavala-Padilla, Guadalupe, Pérez-Carreón, Julio I., Rodríguez-Ambriz, Sandra L., Herrera, Guillermo A., Becerril-Luján, Baltazar, Ochoa-Leyva, Adrián, Melendez-Zajgla, Jorge, Serpell, Louise, del Pozo-Yauner, Luis
Publicado 2019