Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

por Angosto-Bazarra, Diego, Alarcón-Vila, Cristina, Hurtado-Navarro, Laura, Baños, María C., Rivers-Auty, Jack, Pelegrín, Pablo
Publicado 2022

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

por Tapia-Abellán, Ana, Angosto-Bazarra, Diego, Alarcón-Vila, Cristina, Baños, María C., Hafner-Bratkovič, Iva, Oliva, Baldomero, Pelegrín, Pablo
Publicado 2021

P2X7 receptor activation impairs antitumour activity of natural killer cells

por Baroja‐Mazo, Alberto, Peñín‐Franch, Alejandro, Lucas‐Ruiz, Fernando, de Torre‐Minguela, Carlos, Alarcón‐Vila, Cristina, Hernández‐Caselles, Trinidad, Pelegrín, Pablo
Publicado 2022

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

por Martínez, Laura, Torres, Sandra, Baulies, Anna, Alarcón-Vila, Cristina, Elena, Montserrat, Fabriàs, Gemma, Casas, Josefina, Caballeria, Joan, Fernandez-Checa, Jose C., García-Ruiz, Carmen
Publicado 2015

CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

por Alarcón-Vila, Cristina, Baroja-Mazo, Alberto, de Torre-Minguela, Carlos, Martínez, Carlos M, Martínez-García, Juan J, Martínez-Banaclocha, Helios, García-Palenciano, Carlos, Pelegrin, Pablo
Publicado 2020

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

por Baulies, Anna, Ribas, Vicent, Núñez, Susana, Torres, Sandra, Alarcón-Vila, Cristina, Martínez, Laura, Suda, Jo, Ybanez, Maria D., Kaplowitz, Neil, García-Ruiz, Carmen, Fernández-Checa, Jose C.
Publicado 2015

Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis

por Alarcón-Vila, Cristina, Insausti-Urkia, Naroa, Torres, Sandra, Segalés-Rovira, Paula, Conde de la Rosa, Laura, Nuñez, Susana, Fucho, Raquel, Fernández-Checa, Jose C., García-Ruiz, Carmen
Publicado 2023

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

por Torres, Sandra, Matías, Nuria, Baulies, Anna, Nuñez, Susana, Alarcon-Vila, Cristina, Martinez, Laura, Nuño, Natalia, Fernandez, Anna, Caballeria, Joan, Levade, Thierry, Gonzalez-Franquesa, Alba, Garcia-Rovés, Pablo, Balboa, Elisa, Zanlungo, Silvana, Fabrías, Gemma, Casas, Josefina, Enrich, Carlos, Garcia-Ruiz, Carmen, Fernández-Checa, José C.
Publicado 2016

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

por Martínez-García, Juan José, Martínez-Banaclocha, Helios, Angosto-Bazarra, Diego, de Torre-Minguela, Carlos, Baroja-Mazo, Alberto, Alarcón-Vila, Cristina, Martínez-Alarcón, Laura, Amores-Iniesta, Joaquín, Martín-Sánchez, Fátima, Ercole, Giovanni A., Martínez, Carlos M., González-Lisorge, Ada, Fernández-Pacheco, José, Martínez-Gil, Piedad, Adriouch, Sahil, Koch-Nolte, Friedrich, Luján, Juan, Acosta-Villegas, Francisco, Parrilla, Pascual, García-Palenciano, Carlos, Pelegrin, Pablo
Publicado 2019