RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development

por Jo, Seokwon, Alejandro, Emilyn U
Publicado 2023

Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring

por Beetch, Megan, Alejandro, Emilyn U.
Publicado 2021

Window of Opportunity: Targeting ANGPTL4 Improves Triglyceride Levels in Maternal Obesity During Pregnancy

por Alejandro, Emilyn U., Bernlohr, David A.
Publicado 2020

Editorial: Research Topic for Frontiers in Endocrinology (Obesity): Fetal Origin of Obesity and Diabetes

por Sliwowska, Joanna H., Alejandro, Emilyn U., Gesing, Adam
Publicado 2022

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells

por Esch, Nicholas, Jo, Seokwon, Moore, Mackenzie, Alejandro, Emilyn U.
Publicado 2020

Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass

por Wong, Alicia, Akhaphong, Brian, Baumann, Daniel, Alejandro, Emilyn U.
Publicado 2022

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring

por Moore, Mackenzie, Avula, Nandini, Jo, Seokwon, Beetch, Megan, Alejandro, Emilyn U.
Publicado 2021

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity

por Lockridge, Amber, Gustafson, Eric, Wong, Alicia, Miller, Robert F., Alejandro, Emilyn U.
Publicado 2021

O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic α-cell function in mice

por Essawy, Ahmad, Jo, Seokwon, Beetch, Megan, Lockridge, Amber, Gustafson, Eric, Alejandro, Emilyn U.
Publicado 2021

Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model

por Moore, Mackenzie, Avula, Nandini, Wong, Alicia, Beetch, Megan, Jo, Seokwon, Alejandro, Emilyn U.
Publicado 2022

Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

por Jo, Seokwon, Pritchard, Samantha, Wong, Alicia, Avula, Nandini, Essawy, Ahmad, Hanover, John, Alejandro, Emilyn U.
Publicado 2022

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion

por Wong, Alicia, Pritchard, Samantha, Moore, Mackenzie, Akhaphong, Brian, Avula, Nandini, Beetch, Megan, Fujitani, Yoshio, Alejandro, Emilyn U.
Publicado 2023

Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring

por Beetch, Megan, Akhaphong, Brian, Wong, Alicia, Clifton, Briana, Jo, Seokwon, Mohan, Ramkumar, Abrahante Llorens, Juan E, Alejandro, Emilyn U
Publicado 2023

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

por Alejandro, Emilyn U., Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Wasan, Michelle Ann, Elghazi, Lynda, Vadrevu, Suryakiran, Satin, Leslie, Bernal-Mizrachi, Ernesto
Publicado 2017

Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring

por Gregg, Brigid E., Botezatu, Nathalie, Brill, Joshua D., Hafner, Hannah, Vadrevu, Suryakiran, Satin, Leslie S., Alejandro, Emilyn U., Bernal-Mizrachi, Ernesto
Publicado 2018

Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes

por Alejandro, Emilyn U., Mamerto, Therriz P., Chung, Grace, Villavieja, Adrian, Gaus, Nawirah Lumna, Morgan, Elizabeth, Pineda-Cortel, Maria Ruth B.
Publicado 2020

Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice

por Jo, Seokwon, Beetch, Megan, Gustafson, Eric, Wong, Alicia, Oribamise, Eunice, Chung, Grace, Vadrevu, Suryakiran, Satin, Leslie S, Bernal-Mizrachi, Ernesto, Alejandro, Emilyn U
Publicado 2023

Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells

por Zhao, Ming, Ren, Kaiqun, Xiong, Xiwen, Cheng, Meng, Zhang, Zengdi, Huang, Zan, Han, Xiaonan, Yang, Xiaoyong, Alejandro, Emilyn U., Ruan, Hai-Bin
Publicado 2020

Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice

por Akhaphong, Brian, Gregg, Brigid, Kumusoglu, Doga, Jo, Seokwon, Singer, Kanakadurga, Scheys, Joshua, DelProposto, Jennifer, Lumeng, Carey, Bernal-Mizrachi, Ernesto, Alejandro, Emilyn U.
Publicado 2022

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

por Mohan, Ramkumar, Jo, Seokwon, Da Sol Chung, Elina, Oribamise, Eunice, Lockridge, Amber, Abrahante-Lloréns, Juan E., Ruan, Hai-Bin, Yang, Xiao-Yong, Alejandro, Emilyn U.
Publicado 2021