Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

por Taylor, Matthew, Alessi, Dario R.
Publicado 2020

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

por Filippi, Beatrice Maria, Alessi, Dario R.
Publicado 2008

LKB1 and AMPK and the cancer-metabolism link - ten years after

por Hardie, D Grahame, Alessi, Dario R
Publicado 2013

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders

por Muqit, Miratul M K, Alessi, Dario R
Publicado 2009

Cancer, oncogenes and signal transduction

por McManus, Edward J, Alessi, Dario R
Publicado 2004

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

por Wullschleger, Stephan, Sakamoto, Kei, Johnstone, Lana, Duce, Suzanne, Fleming, Stewart, Alessi, Dario R.
Publicado 2011

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

por Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M., Alessi, Dario R.
Publicado 2015

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

por Gomez, Rachel C., Wawro, Paulina, Lis, Pawel, Alessi, Dario R., Pfeffer, Suzanne R.
Publicado 2019

Impact of Type II LRRK2 inhibitors on signaling and mitophagy

por Tasegian, Anna, Singh, Francois, Ganley, Ian G., Reith, Alastair D., Alessi, Dario R.
Publicado 2021

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

por Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Publicado 2014

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

por Sommer, Eeva M., Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R., Alessi, Dario R.
Publicado 2013

Structural insights into the activation of MST3 by MO25

por Mehellou, Youcef, Alessi, Dario R., Macartney, Thomas J., Szklarz, Marta, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2013

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β(MYPT1) phosphatase complex and the SCF(βTrCP) E3 ubiquitin ligase

por Banerjee, Sourav, Zagórska, Anna, Deak, Maria, Campbell, David G., Prescott, Alan R., Alessi, Dario R.
Publicado 2014

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

por Tovell, Hannah, Testa, Andrea, Zhou, Houjiang, Shpiro, Natalia, Crafter, Claire, Ciulli, Alessio, Alessi, Dario R.
Publicado 2019

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

por Waschbüsch, Dieter, Purlyte, Elena, Pal, Prosenjit, McGrath, Emma, Alessi, Dario R., Khan, Amir R.
Publicado 2020

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

por Nirujogi, Raja S., Tonelli, Francesca, Taylor, Matthew, Lis, Pawel, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Publicado 2021

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

por Khan, Shahzad S, Sobu, Yuriko, Dhekne, Herschel S, Tonelli, Francesca, Berndsen, Kerryn, Alessi, Dario R, Pfeffer, Suzanne R
Publicado 2021

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

por Libby, Gillian, Donnelly, Louise A., Donnan, Peter T., Alessi, Dario R., Morris, Andrew D., Evans, Josie M.M.
Publicado 2009

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

por Oi, Katsuyuki, Sohara, Eisei, Rai, Tatemitsu, Misawa, Moko, Chiga, Motoko, Alessi, Dario R., Sasaki, Sei, Uchida, Shinichi
Publicado 2011

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks

por Malik, Nazma, Macartney, Thomas, Hornberger, Annika, Anderson, Karen E., Tovell, Hannah, Prescott, Alan R., Alessi, Dario R.
Publicado 2018