MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

por Venkataraman, Sujatha, Alimova, Irina, Fan, Rong, Harris, Peter, Foreman, Nicholas, Vibhakar, Rajeev
Publicado 2010

ATRT-01. PARP INHIBITION AS A THERAPEUTIC TARGET IN ATRT

por Alimova, Irina, Mardok, Gillian, Pierce, Angela, Wang, Dong, Madhavan, Krishna, Brunt, Breauna, Vibhakar, Rajeev
Publicado 2023

ATRT-08. TARGETING THE TP53-MDM2 ENHANCES RADIATION SENSITIVITY IN ATRT

por Alimova, Irina, Danis, Etienne, Wang, Dong, Pierce, Angela, Serkova, Natalie, Venkataraman, Sujatha, Vibahakar, Rajeev
Publicado 2021

MPS1 kinase as a potential therapeutic target in medulloblastoma

por Alimova, Irina, Ng, June, Harris, Peter, Birks, Diane, Donson, Andrew, Taylor, Michael D., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2016

IMG-17. RADIOMICS CHARACTERIZATION OF FOUR PEDIATRIC BRAIN TUMOR SUBTYPES IN PDX MOUSE MODELS

por Serkova, Natalie, Stukova, Marina, Henehan, Samuel, Steiner, Jenna, Pierce, Angela, Griesinger, Andrea, Veo, Bethany, Alimova, Irina, Venkataraman, Sujatha, Green, Adam, Dahl, Nathan, Foreman, Nicholas, Vibhakar, Rajeev
Publicado 2020

Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

por Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Donson, Andrew M, Knipstein, Jeffrey, Dubuc, Adrian, Taylor, Michael D, Handler, Michael H, Foreman, Nicholas K, Vibhakar, Rajeev
Publicado 2012

Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

por Alimova, Irina, Pierce, Angela M., Harris, Peter, Donson, Andrew, Birks, Diane K., Prince, Eric, Balakrishnan, Ilango, Foreman, Nicholas K., Kool, Marcel, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2017

Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors

por Alimova, Irina, Wang, Dong, Danis, Etienne, Pierce, Angela, Donson, Andrew, Serkova, Natalie, Madhavan, Krishna, Lakshmanachetty, Senthilnath, Balakrishnan, Ilango, Foreman, Nicholas K., Mitra, Siddhartha, Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2022

ATRT-23. SIRT2 cooperates with SMARCB1 to induce a differentiation block in ATRT

por Alimova, Irina, Wang, Dong, Pierce, Angela, Lakshmanachetty, Senthilnath, Prince, Eric, Danis, Etienne, Serkova, Natalie, Madhavan, Krishna, Balakrishnan, Ilango, Yang, Min, Lin, Henning, Foreman, Nicholas, Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2022

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

por Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Balakrishnan, Ilango, Cristiano, Brian, Donson, Andrew M, Dubuc, Adrian M, Taylor, Michael D, Foreman, Nicholas K, Reigan, Philip, Vibhakar, Rajeev
Publicado 2014

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

por Venkataraman, Sujatha, Alimova, Irina, Balakrishnan, Ilango, Harris, Peter, Birks, Diane K, Griesinger, Andrea, Amani, Vladimir, Cristiano, Brian, Remke, Marc, Taylor, Michael D, Handler, Michael, Foreman, Nicholas K, Vibhakar, Rajeev
Publicado 2014

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma

por Amani, Vladimir, Prince, Eric W, Alimova, Irina, Balakrishnan, Ilango, Birks, Diane, Donson, Andrew M., Harris, Peter, Levy, Jean M. Mulcahy, Handler, Michael, Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2016

ATRT-06. SMARCB1 LOSS DRIVEN NON-CANONICAL PRC1 ACTIVITY REGULATES DIFFERENTIATION IN ATYPICAL TERATOID RHABDOID TUMORS (ATRT)

por Alimova, Irina, Danis, Etienne, Weetall, Marla, Pierce, Angela M, Wang, Dong, Serkova, Natalie, Balakrishnan, Ilango, Madhavan, Krishna, Sanford, Bridget, Michel, Cole, Foreman, Nicholas K, Baird, John, Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2020

Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma

por Prince, Eric W., Balakrishnan, Ilango, Shah, Monil, Mulcahy Levy, Jean M., Griesinger, Andrea M., Alimova, Irina, Harris, Peter S., Birks, Diane K., Donson, Andrew M., Davidson, Nathan, Remke, Marc, Taylor, Michael D., Handler, Michael H., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev
Publicado 2016

DIPG-73. SENESCENCE ASSOCIATED SECRETORY PHENOTYPE AS A MECHANISM OF RESISTANCE AND THERAPEUTIC VULNERABILITY IN BMI1 INHIBITOR TREATED DIPG

por Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Bridget, Sanford, Birks, Diane K, Davidson, Nate, Metselaar, Dennis S, Neel, Hans, Donson, Andrew, Griesinger, Andrea, Katagi, Hiroaki, Vijmasi, Trinka, Sola, Ismail, Alimova, Irina, Fosmire, Susan, Hulleman, Esther, Serkova, Natalie J, Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel Montero, Gupta, Nalin, Jones, Ken, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Publicado 2020

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

por Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Sanford, Bridget, Birks, Diane K., Davidson, Nate, Metselaar, Dennis S., Meel, Michaël Hananja, Lemma, Rakeb, Donson, Andrew, Vijmasi, Trinka, Katagi, Hiroaki, Sola, Ismail, Fosmire, Susan, Alimova, Irina, Steiner, Jenna, Gilani, Ahmed, Hulleman, Esther, Serkova, Natalie J., Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel M., Gupta, Nalin, Monje, Michelle, Jabado, Nada, Jones, Kenneth, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Publicado 2020