A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure

por Kriegel, Mark, Wiederanders, Hanna J., Alkhashrom, Sewar, Eichler, Jutta, Muller, Yves A.
Publicado 2021

A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex

por Alkhashrom, Sewar, Kicuntod, Jintawee, Stillger, Katharina, Lützenburg, Tamara, Anzenhofer, Christian, Neundorf, Ines, Marschall, Manfred, Eichler, Jutta
Publicado 2022

Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors

por Alkhashrom, Sewar, Kicuntod, Jintawee, Häge, Sigrun, Schweininger, Johannes, Muller, Yves A., Lischka, Peter, Marschall, Manfred, Eichler, Jutta
Publicado 2021

Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule

por Kicuntod, Jintawee, Alkhashrom, Sewar, Häge, Sigrun, Diewald, Benedikt, Müller, Regina, Hahn, Friedrich, Lischka, Peter, Sticht, Heinrich, Eichler, Jutta, Marschall, Manfred
Publicado 2021

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

por Marschall, Manfred, Häge, Sigrun, Conrad, Marcus, Alkhashrom, Sewar, Kicuntod, Jintawee, Schweininger, Johannes, Kriegel, Mark, Lösing, Josephine, Tillmanns, Julia, Neipel, Frank, Eichler, Jutta, Muller, Yves A., Sticht, Heinrich
Publicado 2020

A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

por Aillaud, Isabelle, Kaniyappan, Senthilvelrajan, Chandupatla, Ram Reddy, Ramirez, Lisa Marie, Alkhashrom, Sewar, Eichler, Jutta, Horn, Anselm H. C., Zweckstetter, Markus, Mandelkow, Eckhard, Sticht, Heinrich, Funke, Susanne Aileen
Publicado 2022

The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity

por Schweininger, Johannes, Kriegel, Mark, Häge, Sigrun, Conrad, Marcus, Alkhashrom, Sewar, Lösing, Josephine, Weiler, Sigrid, Tillmanns, Julia, Egerer-Sieber, Claudia, Decker, Andrea, Lenac Roviš, Tihana, Eichler, Jutta, Sticht, Heinrich, Marschall, Manfred, Muller, Yves A.
Publicado 2022