Extreme Depletion of PIP(3) Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants

por Bharill, Puneet, Ayyadevara, Srinivas, Alla, Ramani, Shmookler Reis, Robert J.
Publicado 2013

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Gao, Yuan, Yu, Li-Rong, Alla, Ramani, Shmookler Reis, Robert
Publicado 2015

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae

por Ayyadevara, Srinivas, Tazearslan, Çagdas, Alla, Ramani, Jiang, James C., Jazwinski, S. Michal, Shmookler Reis, Robert J.
Publicado 2014

PIP(3)-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Alla, Ramani, Mackintosh, Samuel G., Shmookler Reis, Robert J.
Publicado 2016

A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories

por Tarkhov, Andrei E., Alla, Ramani, Ayyadevara, Srinivas, Pyatnitskiy, Mikhail, Menshikov, Leonid I., Shmookler Reis, Robert J., Fedichev, Peter O.
Publicado 2019

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

por Shmookler Reis, Robert J., Xu, Lulu, Lee, Hoonyong, Chae, Minho, Thaden, John J., Bharill, Puneet, Tazearslan, Cagdas, Siegel, Eric, Alla, Ramani, Zimniak, Piotr, Ayyadevara, Srinivas
Publicado 2011

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls

por Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Parcon, Paul A., Barger, Steven W., Griffin, W. Sue T., Alla, Ramani, Tackett, Alan J., Mackintosh, Samuel G., Petricoin, Emanuel, Zhou, Weidong, Shmookler Reis, Robert J.
Publicado 2016

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

por Kakraba, Samuel, Ayyadevara, Srinivas, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Ganne, Akshatha, Liu, Ling, Alla, Ramani, Bommagani, Shoban Babu, Barger, Steven W., Griffin, W. Sue T., Crooks, Peter A., Shmookler Reis, Robert J.
Publicado 2019