Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site

por Gileadi, Opher, Allerston, Charles, von Delft, Frank
Publicado 2013

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase

por Allerston, Charles K., von Delft, Frank, Gileadi, Opher
Publicado 2013

Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators()

por Mota, Filipa, Allerston, Charles K., Hampden-Smith, Kathryn, Garthwaite, John, Selwood, David L.
Publicado 2014

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION

por Cooper, Christopher D. O., Newman, Joseph A., Aitkenhead, Hazel, Allerston, Charles K., Gileadi, Opher
Publicado 2015

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

por Levy, Shiri, Allerston, Charles K., Liveanu, Varda, Habib, Mouna R., Gileadi, Opher, Schuster, Gadi
Publicado 2016

A new small molecule inhibitor of soluble guanylate cyclase

por Mota, Filipa, Gane, Paul, Hampden-Smith, Kathryn, Allerston, Charles K., Garthwaite, John, Selwood, David L.
Publicado 2015

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

por Allerston, Charles K., Lee, Sook Y., Newman, Joseph A., Schofield, Christopher J., McHugh, Peter J., Gileadi, Opher
Publicado 2015

Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging

por Bhargava, Yogesh, Hampden-Smith, Kathryn, Chachlaki, Konstantina, Wood, Katherine C., Vernon, Jeffrey, Allerston, Charles K., Batchelor, Andrew M., Garthwaite, John
Publicado 2013

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases

por Sengerová, Blanka, Allerston, Charles K., Abu, Mika, Lee, Sook Y., Hartley, Janet, Kiakos, Konstantinos, Schofield, Christopher J., Hartley, John A., Gileadi, Opher, McHugh, Peter J.
Publicado 2012

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

por Newman, Joseph A., Savitsky, Pavel, Allerston, Charles K., Bizard, Anna H., Özer, Özgün, Sarlós, Kata, Liu, Ying, Pardon, Els, Steyaert, Jan, Hickson, Ian D., Gileadi, Opher
Publicado 2015

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

por Keates, Tracy, Cooper, Christopher D.O., Savitsky, Pavel, Allerston, Charles K., Phillips, Claire, Hammarström, Martin, Daga, Neha, Berridge, Georgina, Mahajan, Pravin, Burgess-Brown, Nicola A., Müller, Susanne, Gräslund, Susanne, Gileadi, Opher
Publicado 2012

Dataset on Galanin Receptor 3 mutants that improve recombinant receptor expression and stability in an agonist and antagonist bound form

por Ho, Thao T., Nguyen, Jasmine T., Liu, Juping, Stanczak, Pawel, Thompson, Aaron A., Yan, Yingzhuo G., Chen, Jasmine, Allerston, Charles K., Dillard, Charles L., Xu, Hao, Shoger, Nicholas J., Cameron, Jill S., Massari, Mark E., Aertgeerts, Kathleen
Publicado 2017

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

por Couñago, Rafael M., Allerston, Charles K., Savitsky, Pavel, Azevedo, Hatylas, Godoi, Paulo H., Wells, Carrow I., Mascarello, Alessandra, de Souza Gama, Fernando H., Massirer, Katlin B., Zuercher, William J., Guimarães, Cristiano R. W., Gileadi, Opher
Publicado 2017

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

por Jarvis, Ashley, Allerston, Charles K., Jia, Haiyan, Herzog, Birger, Garza-Garcia, Acely, Winfield, Natalie, Ellard, Katie, Aqil, Rehan, Lynch, Rosemary, Chapman, Chris, Hartzoulakis, Basil, Nally, James, Stewart, Mark, Cheng, Lili, Menon, Malini, Tickner, Michelle, Djordjevic, Snezana, Driscoll, Paul C., Zachary, Ian, Selwood, David L.
Publicado 2010

Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor

por Gomez, Eliana B., Ebata, Kevin, Randeria, Hetal S., Rosendahl, Mary S., Cedervall, E. Peder, Morales, Tony H., Hanson, Lauren M., Brown, Nicholas E., Gong, Xueqian, Stephens, Jennifer, Wu, Wenjuan, Lippincott, Isabel, Ku, Karin S., Walgren, Richard A., Abada, Paolo B., Ballard, Joshua A., Allerston, Charles K., Brandhuber, Barbara J.
Publicado 2023

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

por Froese, D. Sean, Forouhar, Farhad, Tran, Timothy H., Vollmar, Melanie, Kim, Yi Seul, Lew, Scott, Neely, Helen, Seetharaman, Jayaraman, Shen, Yang, Xiao, Rong, Acton, Thomas B., Everett, John K., Cannone, Giuseppe, Puranik, Sriharsha, Savitsky, Pavel, Krojer, Tobias, Pilka, Ewa S., Kiyani, Wasim, Lee, Wen Hwa, Marsden, Brian D., von Delft, Frank, Allerston, Charles K., Spagnolo, Laura, Gileadi, Opher, Montelione, Gaetano T., Oppermann, Udo, Yue, Wyatt W., Tong, Liang
Publicado 2013